Olfactory and Visual Perception in Depressed Patients

NCT02857088 | Terminated

• 1 other identifier: P/2011/126
• Study Type: interventional
• Target: 3
• Locations: 1 country
• Sites: 1

Brief Summary

The study aimed to determine the emotional reactivity of depressed patients to visual and olfactory stimuli in comparison with healthy volunteers.

Conditions

Depression

Keywords

depression; emotional reactivity

Outcome Measures

Primary Outcomes (4)

• hedonicity score of visual stimuli

  it will be compared between depressed and non depressed subjects.

  up to 1 month

• skin conductance reactivity amplitude

  it will be compared between depressed and non depressed subjects.

  up to 1 month

• Skin conductance reactivity reaction time

  it will be compared between depressed and non depressed subjects.

  up to 1 month

• hedonicity score of olfactory stimuli

  it will be compared between depressed and non depressed subjects.

  up to 1 month

Study Arms (2)

depressed patients

EXPERIMENTAL

patient with a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment

Behavioral: olfactory assessment; Behavioral: image visualization; Behavioral: psychophysiological assessment

non depressed subject

EXPERIMENTAL

subject without a current unipolar major depressive disorder intervention: olfactory assessment, image visualization and psychophysiological assessment

Behavioral: olfactory assessment; Behavioral: image visualization; Behavioral: psychophysiological assessment

Interventions

olfactory assessment BEHAVIORAL

determination of olfactory sensitivity through olfactory threshold assessment (butanol) determination of hedonicity and intensity of 16 usual odors

depressed patients; non depressed subject

image visualization BEHAVIORAL

20 images (from the IAPS-international affective picture systems) are presented to the subject. He has to determine the hedonicity of each picture.

depressed patients; non depressed subject

psychophysiological assessment BEHAVIORAL

during the olfaction assessment and the image visualization, skin conductance reactivity (SCR) is recorded to assess unconscious emotional reactivity

depressed patients; non depressed subject

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• no cognitive impairment that could prevent instruction comprehension
• no more than 10 cigarettes/day
• signed informed consent
• group 1: current major depressive disorder
• group 2: no current major depressive disorder

You may not qualify if:

• pregnancy
• visual impairment
• olfactory impairment

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead

Study Sites (1)

CHU Besancon

Besançon, Doubs, 25030, France

Location

MeSH Terms

Conditions

Depression

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Study Officials

• Sylvie Nezelof, MD PhD

  Centre Hospitalier Universitaire de Besancon

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2016
• First Posted: August 5, 2016
• Study Start: February 1, 2014
• Primary Completion: April 1, 2014
• Study Completion: April 1, 2016
• Last Updated: August 5, 2016

Record last verified: 2016-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)