Study of Giant Viruses of Amoebas Infections in Children Suffering From Gastroenteritis

NCT02855463 | Unknown

• 1 other identifier: RC12_3755 - 1930
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

The discovery in 2003 by isolation of amoebas Mimivirus, the world's largest virus at the Research Unit on Tropical and Emerging Diseases in Marseille revealed fascinating information about the definition and evolution of viruses. Its genome encodes about 1,000 proteins. Three other viruses were then isolated from amoebas in this unit:Two other giant viruses, Mamavirus Marseillevirus then, and the first virus a virus, named virophage, which led to highlight the role of amoeba (Acanthamoeba spp. ) such as spawning giant viruses and compounds of bacterial origin or cellular proteins This project focuses on the detection and analysis of new viral agents (viruses and virophages giant amoeba environmental) and their involvement in human pathology. The objectives of this study are observational: detect and document the presence of giant viruses and virophages of amoebae in the faeces of children presenting to the pediatric emergency reception service of the North Hospital in AP -HM with or without clinical evidence of gastroenteritis.

Conditions

Gastroenteritis

Keywords

Giant virus; Amoeba

Outcome Measures

Primary Outcomes (1)

• Number of children carriers in their digestive tract of giant viruses (and their virophages) associated with amoebae

  1 day

Eligibility Criteria

• Age: Up to 15 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Children admitted for gastroenteritis who need a microbiological exam to confirm diagnosis

You may qualify if:

• Patient admitted in the Pediatric Emergency Service of Northern Hospital, Marseille, France
• Patient aged ≤ 15.3 years, male or female;
• Patient for whom a microbiological exam should be performed during the clinical management, with or without a clinical diagnosis of gastroenteritis (ie including diarrhea which will be defined by the issuance of at least three molded or watery stools per day for more than 24 hours) at the time of the collection of stool;
• Patient for whom informed consent was read, understood, signed by a parent or legal representative.

You may not qualify if:

• Patient aged \> 15.3 years;
• Patient for whom informed consent is not signed by a parent or legal representative.

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hopitaux de Marseille

Marseille, 13354, France

RECRUITING

MeSH Terms

Conditions

Gastroenteritis

Condition Hierarchy (Ancestors)

Gastrointestinal Diseases; Digestive System Diseases

Study Officials

• Catherine GEINDRE

  Assistance Publique Hôpitaux de Marseille

  STUDY DIRECTOR

Central Study Contacts

Urielle DESALBRES

CONTACT

04 91 38 20 61; urielle.desalbres@ap-hm.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2016
• First Posted: August 4, 2016
• Study Start: July 1, 2011
• Primary Completion: September 1, 2016
• Study Completion: December 1, 2016
• Last Updated: August 4, 2016

Record last verified: 2016-08

Locations

FR (1)