Exercise and Arterial Modulation in Youth

NCT02853747 | Completed DMC

• 1 other identifier: EKNZ258/12
• Study Type: observational
• Target: 337
• Locations: 1 country
• Sites: 1

Brief Summary

The project is designed as a large scale, cross-sectional study. The aim of the study is to investigate the association of micro- and macrovascular function with physical fitness and body composition in primary school children.

Conditions

Cardiovascular Disease; Childhood Obesity; Hypertension; Endothelial Dysfunction

Keywords

arterial stiffness; retinal vessels; physical activity; children

Outcome Measures

Primary Outcomes (1)

• Association of arterial stiffness (pulse wave velocity) with physical fitness in primary school children

  Oscillometric calculation of central pulse wave velocity.

  Through study completion, an average of 1 year.

Secondary Outcomes (3)

• Association of arteriolar-to-venular diameter ratio (AVR) with physical fitness in primary school children

  Through study completion, an average of 1 year.

• Association of subcutaneous advanced glycation endproducts (AGEs) with body composition, blood pressure and physical fitness

  Through study completion, an average of one year.

• Association of lung function (FEV1/VC) with body composition, blood pressure and physical fitness

  Through study completion, an average of one year.

Interventions

Physical Activity, 20-meter shuttle run BEHAVIORAL

cross-sectional physical activity assessment and medical screeening

Eligibility Criteria

• Age: 6 Years - 8 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

ExAMIN YOUTH is a cooperative project between the department of sport, movement and health sciences (DSBG) of the University of Basel and the Cantonal Office of Sport of Basel-Stadt (COS-BS). Primary school children aged 6 to 8 years of the City of Basel are examined.The investigators expect to include n=1200 children in this cross-sectional study.

You may qualify if:

• primary school children aged 6-8 years who can participate in physical education lessons with written consent from their parents.

You may not qualify if:

• children with a medical certificate that prohibits physical exercise with no consent from their parents.

Sponsors & Collaborators

• University of Basel: lead

Study Sites (1)

Bereich Sport- und Bewegungsmedizin, Abteilung Präventive Sportmedizin und Systemphysiologie

Basel, Canton of Basel-City, 4052, Switzerland

Location

Related Publications (9)

• Imhof K, Zahner L, Schmidt-Trucksass A, Faude O, Hanssen H. Influence of physical fitness and activity behavior on retinal vessel diameters in primary schoolchildren. Scand J Med Sci Sports. 2016 Jul;26(7):731-8. doi: 10.1111/sms.12499. Epub 2015 Jun 24.

  PMID: 26105148 BACKGROUND

• Veijalainen A, Tompuri T, Haapala EA, Viitasalo A, Lintu N, Vaisto J, Laitinen T, Lindi V, Lakka TA. Associations of cardiorespiratory fitness, physical activity, and adiposity with arterial stiffness in children. Scand J Med Sci Sports. 2016 Aug;26(8):943-50. doi: 10.1111/sms.12523. Epub 2015 Jul 29.

  PMID: 26220100 BACKGROUND

• Steinmann M, Abbas C, Singer F, Casaulta C, Regamey N, Haffner D, Fischer DC, Simonetti GD. Arterial stiffness is increased in asthmatic children. Eur J Pediatr. 2015 Apr;174(4):519-23. doi: 10.1007/s00431-014-2423-2. Epub 2014 Sep 25.

  PMID: 25248341 BACKGROUND

• Hauser C, Lichtenstein E, Nebiker L, Streese L, Kochli S, Infanger D, Faude O, Hanssen H. Cardiorespiratory fitness and development of childhood cardiovascular risk: The EXAMIN YOUTH follow-up study. Front Physiol. 2023 Aug 23;14:1243434. doi: 10.3389/fphys.2023.1243434. eCollection 2023.

  PMID: 37680774 DERIVED

• Kochli S, Smith W, Lona G, Goikoetxea-Sotelo G, Breet Y, Botha-Le Roux S, Mokwatsi GG, Kruger R, Hanssen H. Obesity, blood pressure and retinal microvascular phenotype in a bi-ethnic cohort of young children. Atherosclerosis. 2022 Jun;350:51-57. doi: 10.1016/j.atherosclerosis.2022.04.018. Epub 2022 Apr 21.

  PMID: 35490596 DERIVED

• Kochli S, Deiseroth A, Hauser C, Streese L, Schmidt-Trucksass A, Faude O, Hanssen H. Body Composition and Physical Fitness Affect Central Hemodynamics in Young Children. Front Pediatr. 2021 Oct 27;9:750398. doi: 10.3389/fped.2021.750398. eCollection 2021.

  PMID: 34778141 DERIVED

• Kochli S, Endes K, Grenacher J, Streese L, Lona G, Hauser C, Deiseroth A, Zahner L, Hanssen H. Socioeconomic Status and Parental Lifestyle Are Associated With Vascular Phenotype in Children. Front Public Health. 2021 Mar 26;9:610268. doi: 10.3389/fpubh.2021.610268. eCollection 2021.

  PMID: 33842418 DERIVED

• Kochli S, Endes K, Bartenstein T, Usemann J, Schmidt-Trucksass A, Frey U, Zahner L, Hanssen H. Lung function, obesity and physical fitness in young children: The EXAMIN YOUTH study. Respir Med. 2019 Nov;159:105813. doi: 10.1016/j.rmed.2019.105813. Epub 2019 Nov 8.

  PMID: 31731085 DERIVED

• Kochli S, Endes K, Steiner R, Engler L, Infanger D, Schmidt-Trucksass A, Zahner L, Hanssen H. Obesity, High Blood Pressure, and Physical Activity Determine Vascular Phenotype in Young Children. Hypertension. 2019 Jan;73(1):153-161. doi: 10.1161/HYPERTENSIONAHA.118.11872.

  PMID: 30571553 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases; Pediatric Obesity; Hypertension; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Henner Hanssen, Prof. Dr. med.

  University of Basel

  PRINCIPAL INVESTIGATOR

• Lukas Zahner, Prof. Dr.

  University of Basel

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.Dr.med. Henner Hanssen

Study Record Dates

• First Submitted: July 25, 2016
• First Posted: August 3, 2016
• Study Start: May 1, 2016
• Primary Completion: May 1, 2018
• Study Completion: May 1, 2018
• Last Updated: September 25, 2023

Record last verified: 2023-09

Locations

CH (1)