Probabilistic Risk Modeling for Disorder Post Traumatic Stress (PTSD) After the Attacks in Paris In November 2015

NCT02853513 | Unknown DMC

• 2 other identifiers: 2016-A00162-49SC16-WEH/BV13
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

The scientific approach of this project proposes to build a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most either came under automatic gunfire or were close to an explosion, whether or not physically injured. The main objective is to define and validate a model of transition from acute stress disorder (ASD) to posttraumatic stress disorder (PTSD) for better detection of the risk of unfavorable and thus better patient supported. The first step is to determine independent risk factors found in analytic prospective cohort study. Bayesian models are well suited to exercise because they can integrate (i) the context related to the patient, (ii) the context related to the trauma itself, and (iii) the immediate reactions and long-term to the latter . They are particularly suited to understanding the brain disordered by saying down information (prior probability) wrong by improper memory of the traumatic event. The confrontation of these descending information and perceived bottom-information could be partly responsible for the symptoms of PTSD. Once validated, the model will characterize the individual level the most at risk of unfavorable patients (calculating a probability of developing PTSD) and to assess the epidemiological impact on long-term cohort of event considered. These determinations are necessary prerequisites to optimize the means of support for these current and future casualties. The investigators main objective is to define a Bayesian model describing a resilient functioning facing a trauma which also allows to describe a possible evolution of the ASD to PTSD by an error. The state of PTSD or not will be determined by the PCL-S scale.

Conditions

Stress Disorders, Post-Traumatic

Outcome Measures

Primary Outcomes (1)

• Post traumatic disorder check list

  PTSD diagnose

  6 months after trauma

Secondary Outcomes (1)

• Hamilton depression scale

  6 months after trauma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most either came under automatic gunfire or were close to an explosion, whether or not physically injured.

You may qualify if:

• patients who directly witnessed the events and having the most either came under automatic gunfire or were close to an explosion, whether or not physically injured

You may not qualify if:

• persons not physically present on the premises at the time of the attacks.
• Inability to understand or read French.
• Persons unable to express personal consent under whose major legal or private protection of liberty by judicial or administrative decision , or hospital emergency or without their consent

Sponsors & Collaborators

• University Hospital, Tours: lead
• Assistance Publique - Hôpitaux de Paris: collaborator
• University of Lorraine: collaborator

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 3, 2016
• First Posted: August 3, 2016
• Study Start: July 1, 2016
• Primary Completion: November 1, 2016
• Study Completion: July 1, 2018
• Last Updated: June 26, 2017

Record last verified: 2017-06