NCT02852603

Brief Summary

Mortality of thoracic aortic aneurysm and dissection (TAAD) remains high because of the huge blood lost from the aorta. Questions about the potentially genetic effects on sporadic TAAD are raised by researchers to explore the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
450

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2014

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2014

Completed
2 years until next milestone

First Submitted

Initial submission to the registry

July 27, 2016

Completed
6 days until next milestone

First Posted

Study publicly available on registry

August 2, 2016

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2019

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2020

Completed
Last Updated

April 13, 2021

Status Verified

April 1, 2021

Enrollment Period

4.4 years

First QC Date

July 27, 2016

Last Update Submit

April 11, 2021

Conditions

Dissection of Aorta, ThoracicAneurysm of Aorta, Thoracic

Keywords

dissectionaneurysmthoracic aorta

Outcome Measures

Primary Outcomes (1)

  • Numbers of patients having thoracic aortic aneurysm and/or dissection are recorded. Diagnosis are confirmed by imaging analysis (CTA and/or Ultrasound) or by doctors during the operations.

    Arterial dissection actually happened

    6 months

Study Arms (1)

thoracic aortic aneurysm and dissection

Patients with thoracic aortic aneurysm and/or dissection are recruited in the study.

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with thoracic aortic aneurysm and dissection.

You may qualify if:

  • Patients with thoracic aortic aneurysm and dissection not due to trauma

You may not qualify if:

  • Inability of the patient, parent or guardian to give consent
  • Unwillingness to provide a blood specimen or participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Wuhan Asia Heart Hospital

Wuhan, Hubei, 430022, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Peripheral whole blood is obtained from patients. Serum, blood cell and DNA are separated and stored for further study.

MeSH Terms

Conditions

Aortic DissectionAortic AneurysmAneurysm

Condition Hierarchy (Ancestors)

Dissection, Blood VesselVascular DiseasesCardiovascular DiseasesAcute Aortic SyndromeAortic Diseases

Study Officials

  • Xuan Zheng, MD, PhD

    Wuhan Asia Heart Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
vice director of laboratory of molecular cardiology

Study Record Dates

First Submitted

July 27, 2016

First Posted

August 2, 2016

Study Start

August 1, 2014

Primary Completion

January 1, 2019

Study Completion

January 1, 2020

Last Updated

April 13, 2021

Record last verified: 2021-04

Locations

CN(1)