Proof of Concept Study Concerning Vestibular Stimulation Using a New Method of Dynamic Posturography.

NCT02851524 | Completed

• 1 other identifier: REVERCHON AOI 2015
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Falls in the elderly population are a major public health problem because of their frequency and their consequences, notably in terms of dependence their cost to society. In most cases, balance disorders related to an impaired vestibular system are blamed, even though there is no formal evidence that this is the case. Vestibular tests in routine otoneurological practice are based on the exploration of vestibulo-ocular or even vestibulo-cortical reflexes. They are not particularly suitable to screen for vestibular disorders in falls. A prototype rocking chair has been developed to test psycho-vestibular pathways, defined as the pathways via which vestibular afferents are transported to the subject's conscience. Thanks to this apparatus, a stimulus of body movement will be generated, but with limited tactile, visual and proprioceptive afferents, in such a way that the vestibular system alone is able to indicate to subjects their position in space. The subject will be required to detect oscillatory movement, and then to distinguish between a vestibular stimulus and a pulsed auditory stimulus. The study hypothesis is that the movement stimulation generated by our prototype will be sufficient to stimulate the vestibular system, which will manifest itself as a conscious sensation of movement and by a vestibulo-ocular reflex causing oculomotor manifestations.

Conditions

Vestibular Stimulation

Outcome Measures

Primary Outcomes (1)

• Cinematics of eye movements (amplitude and direction) evaluated by videonystagmography (VNG).

  At Day 0

Study Arms (1)

posturography

EXPERIMENTAL

Other: posturography

Interventions

posturography OTHER

posturography

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Older than 18 years
• National health insurance cover
• Written consent
• Subjects able to understand simple instructions and packaging information and to provide informed consent

You may not qualify if:

• Vertigo, consciousness disorders, nausea or pain before the tests
• Bilateral deafness
• History of neurological, rheumatic or orthopaedic disease likely by itself to trigger a fall
• Psychiatric disorder likely to compromise participation.
• Personal history of falls of undetermined cause.
• Présence de saccades et/ou nystagmus en position statique
• Femme enceinte

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

CHU Dijon Bourgogne

Dijon, 21079, France

Location

Related Publications (1)

• Guyon M, Chea C, Laroche D, Fournel I, Baudet A, Toupet M, Bozorg Grayeli A. Measuring threshold and latency of motion perception on a swinging bed. PLoS One. 2021 Jul 9;16(7):e0252914. doi: 10.1371/journal.pone.0252914. eCollection 2021.

  PMID: 34242212 RESULT

MeSH Terms

Interventions

Cytidine Diphosphate

Intervention Hierarchy (Ancestors)

Cytosine Nucleotides; Pyrimidine Nucleotides; Pyrimidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Nucleotides; Nucleic Acids, Nucleotides, and Nucleosides; Ribonucleotides

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 28, 2016
• First Posted: August 1, 2016
• Study Start: June 23, 2016
• Primary Completion: April 21, 2017
• Study Completion: April 21, 2017
• Last Updated: February 6, 2026

Record last verified: 2026-02

Locations

FR (1)