Cost and Medical Care of Patients With Advanced Serious Illness in Singapore (COMPASS) Study

NCT02850640 | Unknown

• 1 other identifier: 2015/2781
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 2

Brief Summary

Cost and Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS),is a cohort study which aims to capture health care utilization, cost, and quality of life indicators of patients with advanced cancer and their primary caregivers.

Conditions

Cancer

Outcome Measures

Primary Outcomes (6)

• Change in overall quality of life among patients through the last year of life.

  We will assess patient's quality of life through FACT-G

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Change in anxiety and depression among patients through the last year of life

  We will assess patients' anxiety and depression through the Hospital Anxiety and Depression Scale (HADS).

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Change in pain severity among patients through the last year of life

  We will assess pain reported by patients through visual analog pain scores

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Change in activities of daily living among patients through the last year of life

  We will assess limitations in activities of daily living of patients through OARS Multidimensional Functional Assessment Questionnaire

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Change in patient's perceived quality of care during the last year of life

  We will describe patients' assessment of their own care using a scale used by Ayanian et al (JCO, 2010) that consists of 13 questions.

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Total health care expenditure during the last year of life through analysis of medical bills

  We will calculate total health care expenditure during the last year of patient's life as the sum total of expenditures incurred at clinics etc.

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

Secondary Outcomes (5)

• Change in patient's awareness of prognosis by asking if the patients believe that their current treatment regimen is likely to cure them of cancer

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Change in caregiver burden through the last year of life

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Change in caregiver's levels of emotional distress through the last year of life

  From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)

• Caregiver's perception of patient's end-of-life care assessed after patient's death

  8 weeks bereavement

• Caregivers bereavement adjustment assessed after patient's death

  6 months bereavement

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Stage IV cancer patients, their primary informal caregivers and their treating physicians

You may qualify if:

• Age ≥ 21 years old
• Singaporean or Singapore Permanent Resident
• Diagnosis of advanced/ stage IV solid cancer (for non-breast and non-prostate cancer patients). If it is breast or prostate cancer it should be stage IV with metastases to an organ site.
• Graded 0-2 on the Eastern Cooperative Oncology Group Performance Status
• Intact cognition (of patients ≥60 years of age) as determined by the Abbreviated Mental Test. If patient fails the cognitive test, he/she continues to be eligible for the study although self-reported data will no longer be collected. The Legal Representative of the patient will be approached for providing consent on behalf of the patient, to allow access to review of patient's medical and billing records

You may not qualify if:

• Patients who are not Singaporeans or Singapore Permanent Residents
• Patients who are graded 3 (confined to bed more than 50% of waking hours) and 4 (completely disabled) on the Eastern Cooperative Oncology Group Performance Status.
• Patients who are ≤21 years of age
• Age ≥ 21 years old
• Main person or one of the main providing care to the patient (e.g. accompanying patient for doctor's visits, helping the patient with day to day activities)
• Main person or one of the main ensuring provision of care (e.g. supervision of foreign domestic worker so that the patient is looked after)
• Main person or one of the main involved in making decisions regarding treatment the patient receives
• Patient they are caring for is enrolled in the study
• a) Foreign domestic workers/ maids will be excluded from this study
• Age ≥ 21 years old
• Patients they are treating are enrolled in the study

Sponsors & Collaborators

• Duke-NUS Graduate Medical School: lead
• National Cancer Centre, Singapore: collaborator
• National University Hospital, Singapore: collaborator

Study Sites (2)

National Cancer Centre Singapore

Singapore, 169610, Singapore

Location

National University Hospital

Singapore, 465558, Singapore

Location

Related Publications (4)

• Lee J, Shafiq M, Malhotra R, Ozdemir S, Teo I, Malhotra C. Trajectories of Health-related quality of life in patients with Advanced Cancer during the Last Year of Life: findings from the COMPASS study. BMC Palliat Care. 2022 Oct 14;21(1):183. doi: 10.1186/s12904-022-01075-3.

  PMID: 36242033 DERIVED

• Ozdemir S, Ng S, Chaudhry I, Teo I, Malhotra C, Finkelstein EA; COMPASS Study Group. Caregiver-Reported Roles in Treatment Decision Making in Advanced Cancer and Associated Caregiving Burden and Psychological Distress: A Longitudinal Study. Med Decis Making. 2023 Feb;43(2):191-202. doi: 10.1177/0272989X221125408. Epub 2022 Sep 16.

  PMID: 36113405 DERIVED

• Malhotra C, Bundoc F, Chaudhry I, Teo I, Ozdemir S, Finkelstein E; COMPASS study group. A prospective cohort study assessing aggressive interventions at the end-of-life among patients with solid metastatic cancer. BMC Palliat Care. 2022 May 16;21(1):73. doi: 10.1186/s12904-022-00970-z.

  PMID: 35578270 DERIVED

• Teo I, Singh R, Malhotra C, Ozdemir S, Dent RA, Kumarakulasinghe NB, Yeo WL, Cheung YB, Malhotra R, Kanesvaran R, Yee ACP, Chan N, Wu HY, Chin SM, Allyn HYM, Yang GM, Neo PSH, Nadkarni NV, Harding R, Finkelstein EA. Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol. BMC Cancer. 2018 Apr 23;18(1):459. doi: 10.1186/s12885-018-4356-z.

  PMID: 29688843 DERIVED

MeSH Terms

Conditions

Neoplasms

Study Officials

• Eric A Finkelstein, PhD, MHA

  Duke-NUS Graduate Medical School

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 9, 2016
• First Posted: August 1, 2016
• Study Start: December 1, 2015
• Primary Completion: July 1, 2024
• Study Completion: July 1, 2024
• Last Updated: October 17, 2023

Record last verified: 2023-10

Data Sharing

• IPD Sharing: Will not share

Locations

SG (2)