Muscular Force Generation in Microgravity

NCT02850328 | Unknown

• 1 other identifier: 2014-A00814-43
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the applicability of high-load resistance training as a countermeasure for long term space flights, the current project has two scientific goals. The main objective is to perform a deeper examination of muscle function and MVC in weightlessness (parabolic flight). The secondary objective is to gather further insight into the underlying mechanisms and structures based on investigations targeting the neuromuscular and musculotendinous systems and their interaction.

Conditions

Maximum Voluntary Contraction

Outcome Measures

Primary Outcomes (1)

• maximum voluntary contraction (MVC)

  tested during three different tasks: (1) leg press, (2) plantarflexion and (3) grip strength.

  baseline

Secondary Outcomes (6)

• parameters of muscle function, Rate of force development

  baseline

• parameters of muscle function, Electromyographic activity

  baseline

• parameters of muscle function, Ultrasound measure: fascicle length

  baseline

• parameters of muscle function, Ultrasound measure: pennation angle of the gastrocnemius medialis muscle

  baseline

• parameters of muscle function, Superimposed twitch torque (M-waves at rest and V-waves in MVC conditions)

  baseline

Study Arms (1)

high-load resistance training for long term space flights

OTHER

Short duration electrical will be delivered and the resulting EMG will be recorded. Intensity of electrical stimulation will be progressively increased until we observed a maximal EMG response. Finally an ultrasound probe (similar to that used for prenatal diagnostic imaging) will be fixed behind your calf in order to visualize muscle.

Other: examination of muscle function and MVC in weightlessness

Interventions

examination of muscle function and MVC in weightlessness OTHER

MVC tested during three different tasks: (1) leg press, (2) plantarflexion and (3) grip strength. parameters of muscle function that can be easily implemented in parabolic flight: * Rate of force development * Electromyographic activity * Ultrasound measure: fascicle length and pennation angle of the gastrocnemius medialis muscle * Superimposed twitch torque (M-waves at rest and V-waves in MVC conditions) * Maximum voluntary activation capacity (%VA): %VA = (1-\[torque superimposed twitch/torque resting twitch\])\*100%.

high-load resistance training for long term space flights

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy volunteers (men or women)
• Aged from 21 to 65
• Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC)
• Who accepted to take part in the study
• Who have given their written stated consent
• Who have their right leg as their preferred leg
• Who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There will be no additional test performed for subject selection.
• Subjects will be staff member of the team or of other teams participating in the parabolic flight campaign

You may not qualify if:

• Person with orthopaedic disorders in the upper or lower limbs
• Person with neurological disorders
• Pregnant women

Sponsors & Collaborators

• University Hospital, Caen: lead
• Novespace: collaborator

Study Sites (1)

Caen CHU

Caen, 14000, France

RECRUITING

MeSH Terms

Interventions

Weightlessness

Intervention Hierarchy (Ancestors)

Hypogravity; Gravity, Altered; Gravitation; Astronomical Phenomena; Physical Phenomena

Study Officials

• Pierre DP Denise, PhD

  UMR 1075 UFR de Médecine Caen

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Pierre DP Denise, PhD

CONTACT

02.31.06.81.32; pierre.denise@unicaen.fr

Cathy GC Gaillard

CONTACT

02 31 06 53 49; gaillard-c@chu-caen.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2016
• First Posted: August 1, 2016
• Study Start: September 1, 2014
• Primary Completion: September 1, 2017
• Study Completion: October 1, 2017
• Last Updated: August 18, 2017

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)