An International Survey on Aminoglycoside Practices in Critically Ill Patients: AMINO III Survey
1 other identifier
observational
964
5 countries
85
Brief Summary
This is an international observational cohort study on current aminoglycoside practices in intensive care units. Clinical and demographic data, dosing and therapeutic drug monitoring data will be collected during the first week of aminoglycoside (tobramycin, amikacin or gentamicin) administration in different countries over a year. A minimum of ten consecutive patients will be enrolled at each site.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2016
85 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 21, 2016
CompletedFirst Submitted
Initial submission to the registry
July 27, 2016
CompletedFirst Posted
Study publicly available on registry
July 29, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2017
CompletedNovember 21, 2025
January 1, 2019
1.6 years
July 27, 2016
November 18, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Aminoglycoside current practices descriptive data in intensive care units
Seven first days of aminoglycoside therapy
Secondary Outcomes (3)
Aminoglycoside dosing regimens
Seven first days of aminoglycoside therapy
Aminoglycoside therapy duration
Seven first days of aminoglycoside therapy
Aminoglycoside therapeutic drug monitoring
Seven first days of aminoglycoside therapy
Study Arms (1)
critically ill patients
Critically ill patients admitted in intensive care units and receiving one of the following aminoglycosides: gentamicin, tobramycin and amikacin as part of their usual care.
Interventions
Eligibility Criteria
Large cohort of intensive care units patients receiving aminoglycosides (tobramycin, amikacin or gentamicin) as part of their antimicrobial therapy for sepsis.
You may qualify if:
- Age ≥ 18 years old
- Intensive care unit patients
- Receiving aminoglycoside therapy for a sepsis according to the Third International Consensus Definitions for Sepsis and Septic Shock
You may not qualify if:
- Aged \< 18 years of age
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (85)
Royal Brisbane Women's Hospital
Brisbane, Queensland, 4029, Australia
Royal Brisbane and Women's Hospital
Brisbane, Australia
Frankston Hospital Victoria
Frankston, Australia
Sunshine Coast hospital
Sunshine Coast, Australia
Toowoomba Hospital
Toowoomba, Australia
Hospital Base de Valvidia
Valdivia, Los Ríos Region, Chile
Hospital Barros Luco Trudeau
Santiago, Chile
Hospital CU Chile
Santiago, Chile
Salvador Santiago Hospital
Santiago, Chile
APHM La timone
Marseille, PACA, 13000, France
Centre Hospitalier Aix-En-Provence
Aix-en-Provence, 13097, France
Centre Hospitalier D'Ales
Alès, 30100, France
Chu Amiens
Amiens, 80054, France
Chu Angers
Angers, 49100, France
Chu Angers
Angers, 49933, France
Centre Hospitalier Arles
Arles, 13637, France
CHI Robert Ballanger
Aulnay-sous-Bois, 93602, France
Centre Hospitalier Aurillac
Aurillac, 15000, France
Centre Hospitalier Avignon
Avignon, 84902, France
Chru Besancon
Besançon, 25030, France
Chu Bordeaux
Bordeaux, 33076, France
Centre Hospitalier de BOULOGNE SUR MER
Boulogne-sur-Mer, 62321, France
Centre Hospitalier Bourg En Bresse
Bourg-en-Bresse, 01012, France
Chru Brest
Brest, 29609, France
Chu Brest- Hopital Cavale
Brest, 29609, France
CHU CAEN
Caen, 14033, France
Centre Hospitalier Charleville-Mezieres
Charleville-Mézières, 08011, France
Chu Clermont-Ferrand
Clermont-Ferrand, 63000, France
Centre Hospitalier de Compiegne
Compiègne, 60200, France
Chu Grenoble
Grenoble, 38043, France
Centre Hospitalier La Rochelle-Hopital Saint Louis
La Rochelle, 17019, France
Centre Hospitalier du Mans
Le Mans, 72037, France
Chu Lyon- Hopital La Croix Rousse
Lyon, 69317, France
Chu Lyon- Lyon Sud
Lyon, 69495, France
Aphm- La Conception
Marseille, 13385, France
AP-HM - Hopital Nord
Marseille, 13915, France
Centre Hospitalier Sambre-Avesnois
Maubeuge, 59600, France
Centre Hospitalier de Montauban
Montauban, 82013, France
CHU MONTPELLIER-Hopital Lapeyronnie
Montpellier, 34295, France
CHU MONTPELLIER-Hopital St Eloi
Montpellier, 34295, France
Centre Hospitalier de MORLAIX
Morlaix, 29672, France
Chru Nancy -Hopital de Brabois
Nancy, 54511, France
Chu Nantes- Hopital Hotel Dieu
Nantes, 44035, France
CHU NANTES- hôpital Nord Laennec
Nantes, 44093, France
CHU Nice- Hopital Pasteur
Nice, 06001, France
CHU Nice-Hopital L'Archet
Nice, 06202, France
Centre Universitaire de Nimes
Nîmes, 30029, France
AP-HP - Paris St Louis
Paris, 75010, France
AP-HP - Hopital Paris St Antoine
Paris, 75012, France
Aphp - Pitie Salpetriere
Paris, 75013, France
Aphp- Pitie Salpetriere
Paris, 75013, France
APHP- Bichat
Paris, 75018, France
APHP- Descartes
Paris, 75908, France
APHP-Hopital Georges Pompidou
Paris, 75908, France
AP-HP - Bicetre
Paris, 94275, France
Centre Hospitalier de PAU
Pau, 64046, France
Chu Poitiers
Poitiers, 86021, France
CHU REIMS- Hopital Robert Debré
Reims, 51100, France
CHU RENNES - Hopital Pontchaillou
Rennes, 35033, France
Centre Hospitalier de Roanne
Roanne, 42328, France
Centre Hospitalier de Rodez
Rodez, 12027, France
CHU ROUEN- Hopital Nicolle
Rouen, 76031, France
Centre Hospitalier Sainte Catherine
Saint-Brieuc, 22027, France
CHU La Reunion-Hopital Felix Guyon
Saint-Denis, 97400, France
CHU SAINT-ETIENNE - Hopital Nord
Saint-Etienne, 42270, France
Centre Hospitalier de Salon de Provence
Salon-de-Provence, 13658, France
Centre Hospitalier Sainte Catherine
Saverne, 67703, France
Centre Hospitalier de Toulon, Hopital Sainte Musse
Toulon, 83056, France
CHU TOULOUSE- Hopital Rangueil
Toulouse, 31059, France
Centre Hospitalier Valence
Valence, 26953, France
Centre Hospitalier de Valenciennes
Valenciennes, 59322, France
Athens Hippocratio Hospital
Athens, Greece
Naval and Veterans Hospital of Athens
Athens, Greece
University Critical Care Department Aghioi Anargyroi Hospital
Athens, Greece
University Hospital of loannina
Ioannina, Greece
G. Gennimatas General Hospital
Thessaloniki, Greece
Sandwell and west Birmingham hospital
Birmingham, United Kingdom
University Hospital Birmingham
Birmingham, United Kingdom
Guy'S and St Thomas'
London, United Kingdom
Salford royal
Manchester, United Kingdom
University Hospital of South Manchester
Manchester, United Kingdom
Oxford Radcliffe Hospitals
Oxford, United Kingdom
St Helens and Knowsley Hospitals
Prescot, United Kingdom
Sheffield Teaching Hospitals
Sheffield, United Kingdom
Southampton University Hospitals
Southampton, United Kingdom
Related Publications (1)
Roger C, Louart B, Elotmani L, Barton G, Escobar L, Koulenti D, Lipman J, Leone M, Muller L, Boutin C, Amour J, Banakh I, Cousson J, Bourenne J, Constantin JM, Albanese J, Roberts JA, Lefrant JY; Azurea Network. An international survey on aminoglycoside practices in critically ill patients: the AMINO III study. Ann Intensive Care. 2021 Mar 19;11(1):49. doi: 10.1186/s13613-021-00834-4.
PMID: 33740157RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Claire Roger, MD
Centre Hospitalier Universitaire de Nîmes
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 27, 2016
First Posted
July 29, 2016
Study Start
May 21, 2016
Primary Completion
December 31, 2017
Study Completion
December 31, 2017
Last Updated
November 21, 2025
Record last verified: 2019-01
Data Sharing
- IPD Sharing
- Will not share