Attentional Bias Modification Through Eye-tracker Methodology (ABMET)

NCT02847793 | Completed

• 1 other identifier: PSI2014-61764-EXPLORA
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive biases are a hallmark of depression but there is scarce research on whether these biases can be directly modified by using specific cognitive training techniques. The aim of this study will be targeting and modifying specifically relevant attention biases in participants with subclinical depression using eye-tracking methodologies. This innovative approach has been proposed as a promising future line of intervention in Attention Bias Modification procedures (Koster \& Hoorelbeke, 2015). Recent findings suggest that depression is characterized by a double attentional bias (Duque \& Vazquez, 2015), More specifically, depressed individuals have difficulties both to disengage from negative materials (e.g., sad faces) and to engage with positive materials (e.g., happy faces). Thus, training procedures to change attentional biases should target these two separate components.

Conditions

Cognitive Deficits; Depression; Alteration of Cognitive Function

Keywords

Attentional Bias Modification (ABM); Cognitive Bias Modification (CBM); Depression; Dysphoria; Gaze patterns; Eye-tracking

Outcome Measures

Primary Outcomes (3)

• Assessment of current mood (PANAS)

  A scale measuring current general positive and negative mood

  Change from Baseline to the end of the 2-day intervention.It will be administered 12 min before the first session of training and then immediately after finishing the 2nd session of training

• Assessment of current mood (EVEA)

  A scale measuring current anger, happiness, anxiety and depressed mood

  Change from Baseline to the end of the 2-day intervention. It will be administered 12 min before the first session of training and then immediately after finishing the 2nd session of training.

• Attentional Bias Assessment Task (ABA, Sanchez et al., 2013)

  An eye-tracking task to measure gaze patterns towards emotional faces

  Change from Baseline to the end of the 2-day intervention. It will be administered immediately before the first session of training and then 5 min after finishing the 2nd session of training

Secondary Outcomes (8)

• Beck Depression Inventory-II

  Change from Baseline to the end of the 2-day intervention. It will be administered 20 min before the first session of training and then 20 min after finishing the 2nd session of training

• Beck Anxiety Inventory

  Change from Baseline to the end of the 2-day intervention. It will be administered 20 min before the first session of training and then 20 min after finishing the 2nd session of training.

• Ruminative Responses Scale (RRS)

  Change from Baseline to the end of the 2-day intervention. It will be administered 20 min before the first session of training and then 20 min after finishing the 2nd session of training

• White Bear Suppression Inventory (WBSI)

  Change from Baseline to the end of the 2-day intervention. It will be administered 20 min before the first session of training and then 20 min after finishing the 2nd session of training.

• Behavioral Activation System (BAS)- Behavioral Inhibition System (BIS) Scale

  Change from Baseline to the end of the 2-day intervention. It will be administered 20 min before the first session of training and then 20 min after finishing the 2nd session of training.

Other Outcomes (2)

• Emotional Threshold Detection Task (ETDT).

  Change from Baseline to the end of the 2-day intervention. It will be administered 15 min before the first session of training and then 15 min after finishing the 2nd session of training

• Anagram Stress Task (AST)

  Immediately after the intervention (i.e., after finishing the 2nd session of training). It will be administered 30 min after finishing the 2nd session of training

Study Arms (2)

Gaze training

ACTIVE COMPARATOR

Participants are required to maintain their gaze in a given picture (e.g., a happy face), for a given time (i.e., 750ms vs 1500 ms) to advance to the next trial

Behavioral: Gaze training

Placebo intervention

PLACEBO COMPARATOR

Using a matching procedure (i.e., yoked control group), participants are required to maintain their gaze in a given picture (e.g., a happy face), for the same average time that their counterparts in the Gaze training group (i.e. Experimental group)

Behavioral: Placebo intervention

Interventions

Gaze training BEHAVIORAL

Participants are required to maintain their gaze in a given picture (e.g., a happy face), for a given time (i.e., 750ms vs 1500 ms) to advance to the next trial. (A total of 576 trials will be distributed in a 2-day intervention).

Also known as: Attentional Bias Modification (ABM)

Gaze training

Placebo intervention BEHAVIORAL

Participants are exposed to the same amount of time to the experimental stimuli used in the experimental group but there is no contingency between participants' gaze patterns and the end of each of the 576 trials.

Placebo intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• A score of \>13 in the Beck Depression Inventory (BDI-II)

You may not qualify if:

• Impaired vision

Sponsors & Collaborators

• Universidad Complutense de Madrid: lead
• Ministerio de Economía y Competitividad, Spain: collaborator

Study Sites (1)

School of Psychology

Madrid, 28223, Spain

Location

Related Publications (8)

• Cristea IA, Kok RN, Cuijpers P. Efficacy of cognitive bias modification interventions in anxiety and depression: meta-analysis. Br J Psychiatry. 2015 Jan;206(1):7-16. doi: 10.1192/bjp.bp.114.146761.

  PMID: 25561486 BACKGROUND

• Mogoase C, David D, Koster EH. Clinical efficacy of attentional bias modification procedures: an updated meta-analysis. J Clin Psychol. 2014 Dec;70(12):1133-57. doi: 10.1002/jclp.22081. Epub 2014 Mar 20.

  PMID: 24652823 BACKGROUND

• Emmelkamp PM. Attention bias modification: the Emperor's new suit? BMC Med. 2012 Jun 25;10:63. doi: 10.1186/1741-7015-10-63.

  PMID: 22731990 BACKGROUND

• Macleod C, Holmes EA. Cognitive bias modification: an intervention approach worth attending to. Am J Psychiatry. 2012 Feb;169(2):118-20. doi: 10.1176/appi.ajp.2011.11111682. No abstract available.

  PMID: 22318791 BACKGROUND

• Duque A, Vazquez C. Double attention bias for positive and negative emotional faces in clinical depression: evidence from an eye-tracking study. J Behav Ther Exp Psychiatry. 2015 Mar;46:107-14. doi: 10.1016/j.jbtep.2014.09.005. Epub 2014 Sep 22.

  PMID: 25305417 BACKGROUND

• Sanchez A, Vazquez C, Marker C, LeMoult J, Joormann J. Attentional disengagement predicts stress recovery in depression: an eye-tracking study. J Abnorm Psychol. 2013 May;122(2):303-13. doi: 10.1037/a0031529. Epub 2013 Feb 18.

  PMID: 23421524 BACKGROUND

• Bar-Haim Y, Holoshitz Y, Eldar S, Frenkel TI, Muller D, Charney DS, Pine DS, Fox NA, Wald I. Life-threatening danger and suppression of attention bias to threat. Am J Psychiatry. 2010 Jun;167(6):694-8. doi: 10.1176/appi.ajp.2009.09070956. Epub 2010 Apr 15.

  PMID: 20395400 BACKGROUND

• Vazquez C, Blanco I, Sanchez A, McNally RJ. Attentional bias modification in depression through gaze contingencies and regulatory control using a new eye-tracking intervention paradigm: study protocol for a placebo-controlled trial. BMC Psychiatry. 2016 Dec 8;16(1):439. doi: 10.1186/s12888-016-1150-9.

  PMID: 27931196 DERIVED

MeSH Terms

Conditions

Cognition Disorders; Depression

Condition Hierarchy (Ancestors)

Neurocognitive Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Study Officials

• Carmelo Vazquez, Ph.D:

  Universidad Complutense de Madrid

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Full Professor of Psychopathology

Study Record Dates

• First Submitted: July 22, 2016
• First Posted: July 28, 2016
• Study Start: April 1, 2016
• Primary Completion: April 1, 2017
• Study Completion: July 28, 2017
• Last Updated: October 10, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)