Association Study Postoperative Cognitive Dysfunction Associated With Inflammation Polymorphism

NCT02843152 | Unknown

• 1 other identifier: 14038789
• Study Type: observational
• Target: 330
• Locations: 1 country
• Sites: 1

Brief Summary

This study use Loewenstein cognitive function rating scale to meet the standards of the elderly cognitive function assessment. POCD diagnostic criteria used is the recommended value Z current international law, in order to reduce the effects of exercise, we selected 50 cases of patients with age-matched healthy control group as a spouse, the same scale testing. And Loewenstein Assessment Scale cognitive function after some domestic research proved to have good sensitivity, and easy to test small changes in cognitive ability. Before the investigation began strict inclusion and exclusion criteria, the use of simple intelligence scale exclude preoperative cognitive decline in the elderly significantly, the use of depression rating scale for anxiety rating scale before surgery to exclude severe depression and severe anxiety in elderly self self patient. Testing by the same person in the same way neurocognitive assessment test twice, 7 days apart. Studies in Chinese population, susceptibility SNPs and genetic POCD but there are few reports of this project uses 1: 1 matched case-control study, by comparison POCD SNPs and control groups of different polymorphisms, polymorphisms Discussion Han population of postoperative cognitive dysfunction associated with susceptibility to find Chinese Han population of postoperative cognitive disorders genetic susceptibility markers, which provide scientific screening and early diagnosis of postoperative cognitive impairment at high risk in accordance with

Conditions

POCD

Outcome Measures

Primary Outcomes (1)

• Determine the relevance of inflammation-related genes and SNPs of susceptible POCD

  In this study of an international research organization POCD recommended Z-score method to determine postoperative cognitive dysfunction, and is divided into POCD and non POCD group, if the composite Z-score ≥1.96 or have two or more individual test Z-score greater than or equal 1.96 considers the patient POCD group, otherwise non POCD group. They were recorded POCD group and non-POCD group education of patients, medical history, surgery time, anesthesia time, and the amount of narcotic drugs, hypotension, hypertension, postoperative pain, complications, smoking, drinking, blood samples were analyzed patient patients with IL-1β, IL-6, IL-10, VDR, BDNF gene polymorphism

  1 year

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Study subjects were Chinese Han population,Xuzhou Medical College Hospital orthopedic ward in elderly patients

You may qualify if:

• Education for primary ((0 \<schooling ≤6)
• The operation time was 60 \~ 180min
• ASA classification as Class II

You may not qualify if:

• No history of cerebrovascular disease
• No history of central nervous system injury caused by the impact of other cognitive functions
• No alcohol dependence and other substance abuse history
• No vision can severely affect cognitive tests, hearing and limb movement disorder

Sponsors & Collaborators

• dengji wang: lead

Study Sites (1)

Affiliated Hospital of Xuzhou Medical College

Xuzhou, Jiangsu, 221000, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

whole blood

Study Officials

• junli cao

  Jiangsu Key Laboratory of Anesthesiology chinese

  STUDY CHAIR

Central Study Contacts

dengji wang

CONTACT

+8618761420798; 574658525@qq.com

yaodong zhang

CONTACT

+8615205217216

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Investigator

Study Record Dates

• First Submitted: June 25, 2016
• First Posted: July 25, 2016
• Study Start: May 1, 2015
• Primary Completion: September 1, 2016
• Study Completion: September 1, 2016
• Last Updated: July 25, 2016

Record last verified: 2016-07

Locations

CN (1)