Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
1 other identifier
interventional
60
1 country
1
Brief Summary
This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2014
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2014
CompletedFirst Submitted
Initial submission to the registry
July 15, 2016
CompletedFirst Posted
Study publicly available on registry
July 25, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2016
CompletedJanuary 16, 2017
January 1, 2017
1.9 years
July 15, 2016
January 13, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Carotid-femoral pulse wave velocity
Assessed using applanation tonometry
12 weeks post exercise training
Secondary Outcomes (2)
Common carotid artery distensibility
12 weeks post exercise training
Left ventricular mass
12 weeks post exercise training
Study Arms (2)
Resistance exercise training
EXPERIMENTALWhole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.
Non-exercising control
NO INTERVENTIONContinue habitual physical activity for 12 weeks.
Interventions
8-12 reps/set at \~80% 1 repetition maximum
20-25 reps/set at \~30% 1 repetition maximum
Eligibility Criteria
You may qualify if:
- Male
- Aged 18-30 years old
- Non-obese (Body mass index less than 30 kg/m2)
- Non-smoker
- Healthy based on questionnaire responses
- Resistance trained (Resistance training \> 2 times per week for 2 years, minimum 1 lower body exercise session per week)
You may not qualify if:
- Allergies to milk proteins (whey or casein)
- Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
- Arthritic conditions
- Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
- A history of neuromuscular problems
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
McMaster University
Hamilton, Ontario, L8S4L8, Canada
Study Officials
- PRINCIPAL INVESTIGATOR
Stuart M Phillips, PhD
McMaster University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
July 15, 2016
First Posted
July 25, 2016
Study Start
September 1, 2014
Primary Completion
August 1, 2016
Study Completion
August 1, 2016
Last Updated
January 16, 2017
Record last verified: 2017-01