Relation Between NLR and IMR in STEMI Patients

NCT02828137 | Completed Results DMC

• 1 other identifier: INHAUH 2016-06-012
• Study Type: observational
• Target: 123
• Locations: 0 countries
• Sites: N/A

Brief Summary

The neutrophil-to-lymphocyte ratio (NLR) has been proven to be reliable inflammatory marker for atherosclerotic process and predictor for clinical outcomes in patients with various cardiovascular diseases. Recent study reported elevated NLR was associated with impaired myocardial perfusion in ST-segment elevation myocardial infarction (STEMI) patients. The investigators sought to determine whether NLR is associated with coronary microcirculation assessed by index of microcirculatory resistance (IMR) in STEMI patients who undergone primary percutaneous coronary intervention (PCI). A total of 123 patients with STEMI underwent successful primary PCI were consecutively enrolled. NLR at admission was calculated, and the patients were divided into three groups according to NLR tertiles. IMR was measured by intracoronary thermodilution-derived method immediately after index PCI.

Conditions

Myocardial Infarction; Death

Outcome Measures

Primary Outcomes (1)

• Index of Microcirculatory Resistance

  IMR in low NLR group : 21.94 ± 12.87 IMR in intermediate NLR group : 23.22 ± 12.73 IMR in high NLR group : 32.95 ± 20.60

  3 months

Study Arms (3)

Low NLR group

Neutrophil-to-Lymphocyte (NLR) Ratio \< 1.78

Intermediate NLR group

1.78 \< Neutrophil-to-Lymphocyte (NLR) Ratio \< 3.90

High NLR group

Neutrophil-to-Lymphocyte (NLR) Ratio \> 3.90

Eligibility Criteria

• Age: 30 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 123 consecutive STEMI patients who underwent successful primary PCI and coronary physiologic study immediately after PCI were retrospectively enrolled in the study. All patients underwent index PCI between May 2009 and October 2014 at INHA university hospital.

You may qualify if:

• STEMI patients who undergone primary PCI

You may not qualify if:

• unprotected left main coronary artery disease
• stent thrombosis presentation
• a history of coronary artery bypass graft surgery
• prior intravenous thrombolytic therapy before PCI
• high degree atrioventricular block
• remained cardiogenic shock after complete PCI
• contraindication for use of adenosine
• post-PCI thrombolysis in myocardial infarction (TIMI) flow grade 0 or 1

Sponsors & Collaborators

• Inha University Hospital: lead

Related Publications (1)

• Lee MJ, Park SD, Kwon SW, Woo SI, Lee MD, Shin SH, Kim DH, Kwan J, Park KS. Relation Between Neutrophil-to-Lymphocyte Ratio and Index of Microcirculatory Resistance in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Am J Cardiol. 2016 Nov 1;118(9):1323-1328. doi: 10.1016/j.amjcard.2016.07.072. Epub 2016 Aug 13.

  PMID: 27600462 DERIVED

MeSH Terms

Conditions

Myocardial Infarction; Death

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Results Point of Contact

• Title: Dr. Sung Woo Kwon
• Organization: Inha University Hospital

kwonswdr@gmail.com

821031133363

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 30, 2016
• First Posted: July 11, 2016
• Study Start: May 1, 2009
• Primary Completion: October 1, 2014
• Study Completion: December 1, 2014
• Last Updated: August 22, 2016
• Results First Posted: August 22, 2016

Record last verified: 2016-06