Strigolactones and Dysplastic Colonic Lesions or Cancer

NCT02824835 | Unknown

• 1 other identifier: IDO123
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.

Conditions

Colonic Neoplasms; Colonic Polyps

Outcome Measures

Primary Outcomes (2)

• percentage of cells with reduced viability after dose-dependent exposure

  24 hours of exposure to strigolactone

• percentage of cells in G2/M arrest after dose-dependent exposure

  analysis of cell cycle

  24 hours of exposure to strigolactone

Study Arms (2)

adenoma group

Patients with adenoma. Biopsies are taken before endoscopic resection.

Procedure: biopsy during colonoscopy

cancer group

Patients with colorectal cancer. Biopsies are taken before surgical resection.

Procedure: biopsy during colonoscopy

Interventions

biopsy during colonoscopy PROCEDURE

sampling the lesion with forcept biopter

adenoma group; cancer group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients undergoing colonoscopy who have positive findings (polyps, cancer) during the procedure

You may qualify if:

• Patients with positive findings during colonoscopy

You may not qualify if:

• Patients below 18 years old
• Patients who cannot sign a consent form

Sponsors & Collaborators

• Meir Medical Center: lead

Related Publications (2)

• Mayzlish-Gati E, Laufer D, Grivas CF, Shaknof J, Sananes A, Bier A, Ben-Harosh S, Belausov E, Johnson MD, Artuso E, Levi O, Genin O, Prandi C, Khalaila I, Pines M, Yarden RI, Kapulnik Y, Koltai H. Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model. Cancer Biol Ther. 2015;16(11):1682-8. doi: 10.1080/15384047.2015.1070982. Epub 2015 Jul 20.

  PMID: 26192476 BACKGROUND

• Pollock CB, Koltai H, Kapulnik Y, Prandi C, Yarden RI. Strigolactones: a novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells. Breast Cancer Res Treat. 2012 Aug;134(3):1041-55. doi: 10.1007/s10549-012-1992-x. Epub 2012 Mar 29.

  PMID: 22476848 BACKGROUND

MeSH Terms

Conditions

Colonic Neoplasms; Colonic Polyps

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Polyps; Polyps; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Ido Laish, MD

  Meir Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ido Laish, MD

CONTACT

+ 972-9-7473261; ido.lish@clalit.org.il

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: June 27, 2016
• First Posted: July 7, 2016
• Study Start: July 1, 2016
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: July 7, 2016

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share