Brain and Cognitive Reserve
BCN
Neuro-anatomical Correlates on Volumetric MRI on the Impact of Brain Reserve and Cognitive Reserve on Ischemic Strokes in Elderly
1 other identifier
interventional
20
1 country
1
Brief Summary
Ischemic strokes are one of the leading causes of handicap and death in elderly people in France. Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental factors that explain differential susceptibility to functional impairment in the presence of pathology or other neurological insult. CR is estimated using variables for cognitive activity: years of education, professional status, socioeconomic status… Furthermore, brain reverse (BR) is a passive and quantitative model that depend on brain size and other quantitative aspects of the brain that explain differential susceptibility to functional impairment in the presence of pathology. Firstly, volume and localization of ischemic strokes have a great impact on CR and BR due to brain injury. On the other hand, CR influences the severity and the expression of cognitive diseases. The investigators realize a prospective study in order to assess the impact of CR and BR on cognitive prognosis after a right middle cerebral artery ischemic stroke in elderly patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2016
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 26, 2016
CompletedFirst Submitted
Initial submission to the registry
June 28, 2016
CompletedFirst Posted
Study publicly available on registry
June 30, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2016
CompletedNovember 20, 2017
November 1, 2017
2 months
June 28, 2016
November 16, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
evaluation of cognitive prognosis
measure will be performed with the Mattis dementia rating scale
one year post Ischemic stroke
Secondary Outcomes (5)
Volume of leucoencephalopathy
one year post Ischemic stroke
volume of hippocampic
one year post Ischemic stroke
brain injury
one year post Ischemic stroke
volume of ischemic stroke
one year post Ischemic stroke
evaluation of cognitive reserve
one year post Ischemic stroke
Study Arms (1)
neurologic and neuropsychological evaluation
OTHERInterventions
cognitive prognosis, cognitive reserve, brain volume will be studied on patients with scale, questionnaire, magnetic resonance imaging
Eligibility Criteria
You may qualify if:
- ≥70 years old
- right middle cerebral artery ischemic stroke
- hospitalized in neurovascular unit of Pierre Wertheimer hospital between January 2015 to January 2016
You may not qualify if:
- Contraindication for MRI
- Hemorrhagic stroke
- Aphasia
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hôpital des Charpennes
Lyon, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Pierre Krolak Salmon, MD
Hospices Civils de Lyon
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 28, 2016
First Posted
June 30, 2016
Study Start
May 26, 2016
Primary Completion
August 1, 2016
Study Completion
August 1, 2016
Last Updated
November 20, 2017
Record last verified: 2017-11