Study to Assess Antioxidant Efficacy of Spirulina on oxLDL and Lipids Metabolism on Subjects With Metabolic Syndrome

NCT02817620 | Completed

• 1 other identifier: PEC15039
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this pilot study is to assess the beneficial effect of a spirulina water extract (product named Spirulysat®) compared to a placebo in the blood level ratio of oxidized LDL / total LDL cholesterol in subjects with metabolic syndrome after 12 weeks of consumption

Conditions

Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Changes in the ratio of fasting blood concentrations oxidized LDL / total LDL cholesterol

  Defined as the difference V3 (12 weeks) - V1 (baseline) in mU/g

  12 weeks

Secondary Outcomes (17)

• Changes in the ratio of fasting blood concentrations oxidized LDL / total LDL cholesterol

  6 weeks

• Changes in fasting blood oxidized LDL level

  6 weeks

• Changes in fasting blood oxidized LDL level

  12 weeks

• Changes in fasting blood concentrations of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides

  6 weeks

• Changes in fasting blood concentrations of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides

  12 weeks

Other Outcomes (40)

• Bile acids levels in stool (desoxycholic acid, lithocholic acid, cholic acid, chenodesoxycholic acid, bile salt, ursodesoxycholic acid)

  Baseline

• Bile acids levels in stool (desoxycholic acid, lithocholic acid, cholic acid, chenodesoxycholic acid, bile salt, ursodesoxycholic acid)

  6 weeks

• Bile acids levels in stool (desoxycholic acid, lithocholic acid, cholic acid, chenodesoxycholic acid, bile salt, ursodesoxycholic acid)

  12 weeks

Study Arms (2)

Spirulysat®

EXPERIMENTAL

Food supplement packaged in 10 ml vials called Spirulysat®. This product is a phycocyanin concentrated fresh spirulina water extract (Spirulina Platensis). 2 vials daily to consume in the morning, just before the breakfast, in a glass of water, during 12 weeks (from V1 to V3 visit).

Dietary Supplement: Spirulysat®

Placebo

PLACEBO COMPARATOR

Placebo with the same characteristics, appearance, packaging and composition as the active formula except for active ingredient (Spirulina) replaced by a classical blue food colorant used to colour desserts. 2 vials daily to consume in the morning, just before the breakfast, in a glass of water, during 12 weeks (from V1 to V3 visit).

Dietary Supplement: Placebo

Interventions

Spirulysat® DIETARY_SUPPLEMENT

Spirulysat®

Placebo DIETARY_SUPPLEMENT

Placebo

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• To be eligible to the study, male and female volunteers will have to fulfil the following criteria (assessment based on the medical examination performed at V0 with a checking at V1):
• Age between 18 and 65 years (limits included),
• BMI between 25 and 35 kg/m² (limits included),
• With metabolic syndrome defined as central obesity : waist circumference \> 94 cm for man and \> 80 cm for woman associated to at least 2 observed criteria among : Fasting blood triglycerides \> 1.5 g/L and/or Fasting blood HDL cholesterol \< 0.4 g/L for man and \< 0.5 g/L for woman and/or Fasting blood glucose level \> 1 g/L and/or Arterial pressure \> 130/85 mmHg or under antihypertensive treatment,
• For women : non menopausal with the same reliable contraception since at least 3 months before the beginning of the study and agreeing to keep it during the entire duration of the study (condom with spermicide gel accepted) or menopausal without or with hormone replacement therapy started at stable dose since at least 3 months before the beginning of the study and agreeing to keep it during the entire duration of the study,
• Weight stable with +/- 5 % in the last 3 months ,
• Non smoking or with tobacco consumption \< 10 cigarettes / day,
• Good general and mental health with in the opinion of the investigator : no clinically significant and relevant abnormalities of medical history or physical examination,
• Able and willing to participate to the study by complying with the protocol procedures as evidenced by his dated and signed informed consent form,
• Affiliated with a social security scheme,
• Agree to be registered on the volunteers in biomedical research file,
• After V0 biological analysis the subjects will be eligible to the study on the following criterion :
• Blood fasting lipid profile not requiring therapeutic intervention meaning professional recommendations (AFSSAPS, 2005).

You may not qualify if:

• Volunteers with the following criteria will be considered as non eligible to the study (assessment based on the medical examination performed at V0 with a checking at V1):
• Suffering from a metabolic disorder such as diabetes, uncontrolled thyroidal trouble...,
• Suffering from a severe chronic disease (e.g. cancer, HIV, renal failure, hepatic or biliary disorders ongoing, chronic inflammatory digestive disease, arthritis or other chronic respiratory trouble, etc.) or gastrointestinal disorders found to be inconsistent with the conduct of the study by the investigator (e.g. celiac disease),
• With a history of ischemic cardiovascular event,
• Having undergone recent surgical procedure (less than 6 months),
• Suffering from an uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg),
• With a known or suspected food allergy or intolerance or hypersensitivity to any of the study products' ingredient,
• Pregnant or lactating women or intending to become pregnant within 4 months ahead,
• Under cholesterol and/or lipid-lowering treatment (e.g. statins, fibrates, ezetimibe, bile acid sequestrants, niacin, etc.) or stopped less than 3 months before the V0 visit,
• Under medication which could affect blood lipid parameters (e.g. long-term corticosteroid systemic drug, systemic antibodies, androgens or enzyme inducers, etc.) or stopped less than 3 months before the V0 visit (antihypertensive stable long-term treatment tolerated),
• Regular intake of dietary supplements or "functional foods" which are known to have an impact on lipid metabolism (e.g. rich in plant stanol or sterol like PRO-ACTIV or DANACOL products, red yeast rice, policosanol, capsules containing omega-3 fatty acids from fish oils, etc.) or stopped less than 3 months before the V0 visit,
• Under treatment or dietary supplement which could significantly affect parameter(s) followed during the study according to the investigator or stopped in a too short period before the V0 visit,
• With significant change in food habits or in physical activity in the 3 months before the V0 visit or not agreeing to keep them unchanged throughout the study,
• With a current or planned in the next 4 months specific diet (hyper or hypocaloric, vegan, vegetarian...) or stopped less than 3 months before the V0 visit,
• With a personal history of anorexia nervosa, bulimia or significant eating disorders according to the investigator,

Sponsors & Collaborators

• Algosource: lead
• Biofortis Mérieux NutriSciences: collaborator

Study Sites (1)

Biofortis Mérieux NutriSciences Clinical Investigation Center

Saint-Herblain, 44800, France

Location

MeSH Terms

Conditions

Metabolic Syndrome

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Sophie SCHMID

  Biofortis Mérieux NutriSciences

  STUDY DIRECTOR

• David GENDRE

  Biofortis Mérieux NutriSciences

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 27, 2016
• First Posted: June 29, 2016
• Study Start: August 24, 2016
• Primary Completion: September 14, 2017
• Study Completion: September 14, 2017
• Last Updated: September 18, 2017

Record last verified: 2017-09

Locations

FR (1)