Study of Neural Inspiratory Time and Expiratory Delay in Patient and Health During Spontaneous Breathing and Ventilation

NCT02817035 | Completed DMC

• 1 other identifier: yls2016
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

To make these definitions of neural inspiratory time (Ti) and expiratory delay clearly.The present study was undertaken to examined the physiological signals of patients and healthy subjects during spontaneous breathing and noninvasive mechanical ventilation.

Conditions

State Key Laboratory of Respiratory Disease

Keywords

interstitial lung disease; chronic obstructive pulmonary disease; mechanical ventilation; expiratory delay; neural inspiratory time

Outcome Measures

Primary Outcomes (1)

• neural inspiratory time

  Compare the neural inspiratory time during spontaneous breathing and noninvasive mechanical ventilation.

  20-30 minutes

Secondary Outcomes (1)

• expiratory delay

  20-30 minutes

Study Arms (1)

noninvasive mechanical ventilation

EXPERIMENTAL

To investigate the change of the neural inspiratory time and expiratory delay noninvasive mechanical ventilation ,in comparison to spontaneous breathing

Device: noninvasive mechanical ventilation

Interventions

noninvasive mechanical ventilation DEVICE

To examined the physiological signals of patients and healthy subjects during spontaneous breathing and noninvasive mechanical ventilation.

noninvasive mechanical ventilation

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• chronic obstructive pulmonary disease patient meet the diagnose criteria of chronic obstructive pulmonary disease
• interstitial lung disease patient meet the diagnose criteria of interstitial lung disease
• healthy subjects No history of the lung and Cardiovascular disease.The lung function is normal.

You may not qualify if:

• severe Cardiovascular disease
• Pneumonia
• neuromuscular and chest wall deformity
• Respiratory arrest
• Cardiovascular instability (hypotension, arrhythmias, myocardial infarction)
• Change in mental status; uncooperative patient
• High aspiration risk
• Viscous or copious secretions
• Recent facial or gastroesophageal surgery
• Craniofacial trauma
• Fixed nasopharyngeal abnormalities
• Burns
• Extreme obesity

Sponsors & Collaborators

• The First Affiliated Hospital of Guangzhou Medical University: lead

Study Sites (1)

TheFirst Affiliated Hospital Of Guangzhou Medical Collage

Guangzhou, Guangdong, 510000, China

Location

MeSH Terms

Conditions

Lung Diseases, Interstitial; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• rongchang chen, MD

  The First Affiliated Hospital of Guangzhou Medical University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: June 16, 2016
• First Posted: June 29, 2016
• Study Start: June 1, 2016
• Primary Completion: November 1, 2016
• Study Completion: November 1, 2016
• Last Updated: November 15, 2016

Record last verified: 2016-11

Locations

CN (1)