Evaluation of the Quality of Life in the Elderly With Dementia : Validation of a Specific Instrument

NCT02814773 | Completed

• 1 other identifier: 112N04
• Study Type: observational
• Target: 310
• Locations: 1 country
• Sites: 1

Brief Summary

With nearly one million cases of dementia in France in 2010, Alzheimer's disease (AD) and related syndromes are a major public health issue. The lake of drug for treatment or preventing AD, health related quality of life (HRQoL) became an essential criterion of evaluation to assess the treatment strategies of patients. Generic HRQoL tools are generally less sensitive for a given disease. That is why other specific tools for AD have been developed. None of them was validated in French. The aim of this study was therefore, after a review of the literature, to achieve a cross-cultural adaptation and psychometric validation of the "Quality of Life in Alzheimer's Disease" (QoL-AD) and "Dementia Quality of Life" (DQoL). These two questionnaires were selected because they were the most popular in English- language literature for this disease.This study concerned a total of 155 patient-caregiver pairs recruited from six French hospitals and a Francophone Swiss center. Patients had a confirmed diagnosis of AD (mild stage to moderate: Mini Mental State Examination ≥ 10). QoL-AD and DQoL were administered by an interviewer. The caregiver sheet of QoL-AD was self-administered. Cross-cultural adaptation and psychometric validation have been carried out for these two questionnaires.

Conditions

Dementia

Outcome Measures

Primary Outcomes (1)

• The psychometric properties of QoL-AD and DQoL measured by questionnaire

  30 months

Study Arms (1)

AD group

group suffering from Alzheimer-type dementia (mild to moderate dementia)

Other: questionnaires

Interventions

questionnaires OTHER

AD group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients included were recruited in centres with a memory clinic or a geriatric ward.

To be included in the study, patients had to be : * 65 years or older; * native French speakers; * living at home or in an institution; * suffering from Alzheimer-type dementia defined according to DSM IV criteria, and had to obtain a score of 10 on the MMSE corresponding from mild to moderate dementia * to have a main caregiver able to read. Were not included in the cohort study , patients : * From age 65; * Achieved an evocative syndrome of dementia is not in accordance with the criteria DSM IV; * From a mother tongue other than French; * Possessing no help; * With a MMSE score \<10 , so with severe dementia; * Hospitalized in short , medium or long stay; * Having refused to participate in the study .

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• CHU de Reims: lead

Study Sites (1)

Chu Reims

France, Reims, 51092, France

Location

Related Publications (4)

• Wolak A, Novella JA, Drame M, Morrone I, Boyer F, Blanchard F, Jolly D. Is the screening test of the French version of the dementia quality of life questionnaire indispensable? Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):84-92. doi: 10.1159/000326782. Epub 2011 Apr 6.

  PMID: 22279447 RESULT

• Wolak A, Novella JL, Drame M, Guillemin F, Di Pollina L, Ankri J, Aquino JP, Morrone I, Blanchard F, Jolly D. Transcultural adaptation and psychometric validation of a French-language version of the QoL-AD. Aging Ment Health. 2009 Jul;13(4):593-600. doi: 10.1080/13607860902774386.

  PMID: 19629785 RESULT

• Barbe C, Morrone I, Wolak-Thierry A, Drame M, Jolly D, Novella JL, Mahmoudi R. Impact of functional alterations on quality of life in patients with Alzheimer's disease. Aging Ment Health. 2017 May;21(5):571-576. doi: 10.1080/13607863.2015.1132674. Epub 2016 Jan 8.

  PMID: 26745259 RESULT

• Barbe C, Jolly D, Morrone I, Wolak-Thierry A, Drame M, Novella JL, Mahmoudi R. Factors associated with quality of life in patients with Alzheimer's disease. BMC Geriatr. 2018 Jul 9;18(1):159. doi: 10.1186/s12877-018-0855-7.

  PMID: 29986669 DERIVED

MeSH Terms

Conditions

Dementia

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2016
• First Posted: June 28, 2016
• Study Start: May 1, 2006
• Primary Completion: November 1, 2008
• Study Completion: June 1, 2009
• Last Updated: September 26, 2016

Record last verified: 2016-09

Locations

FR (1)