Resilience and Modification of Brain Control Network Following November 13

NCT02810197 | Completed

• 1 other identifier: C16-13
• Study Type: interventional
• Target: 216
• Locations: 1 country
• Sites: 1

Brief Summary

This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after trauma in exposed participants as well as in control non-exposed participants. This project will capitalize on recent evidence showing that healthy participants can prevent unwanted images from entering consciousness using inhibitory control and memory suppression techniques, disrupting traces of the memories in sensory areas of the brain, and weakening their vividness and later reentrance. This process is believed to be affected in Post-traumatic stress disorder (PTSD) which is characterized by anxiety and persistent intrusive memory of the traumatic event with highly distressing contents. This project will thus provide a unique opportunity to observe the online and structural dysfunctions of intrusion control network following a severe psychological trauma and how such process may contribute to recovery and psychopathological dynamics. In addition, the disruption of social cognition and emotional processing following PTSD will also be investigated in relation to disrupted inhibitory control functioning.

Conditions

Post-Traumatic Stress Disorder

Outcome Measures

Primary Outcomes (1)

• Blood Oxygen Level Dependent (BOLD) response as measured with fMRI

  1 hour

Study Arms (2)

Exposed group

EXPERIMENTAL

Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI)

Behavioral: Psychopathological assessment; Behavioral: Neuropsychological assessment; Device: Functional magnetic resonance imaging (fMRI)

unexposed group

EXPERIMENTAL

Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI)

Behavioral: Psychopathological assessment; Behavioral: Neuropsychological assessment; Device: Functional magnetic resonance imaging (fMRI)

Interventions

Psychopathological assessment BEHAVIORAL

Exposed group; unexposed group

Neuropsychological assessment BEHAVIORAL

Exposed group; unexposed group

Functional magnetic resonance imaging (fMRI) DEVICE

Exposed group; unexposed group

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants between 18 and 55 years old.
• Present at the scene of the attacks the evening of 13 November 2015 or inhabitant of one of the neighbourhood affected by the attacks (exposed group), or persons were not in Paris on the evening of the attacks and not residing in Paris and its region (unexposed group).
• Affiliated to the French national health care system
• Have a good knowledge of the French language
• Right-handed
• Body mass less than or equal to 35kg/m2
• Signed written consent form

You may not qualify if:

• Pregnancy or intent to get pregnant
• Person deprived of their liberty
• Person admitted to a health or social institution for purposes other than research
• Minor
• History of severe psychiatric disorders before the attacks : psychotic disorders, bipolar disorder, obsessive compulsive disorder and / or substance use disorders (excluding tobacco addiction)
• Use of medication that may interfere with cognitive or cerebral functioning
• Presence of visual or hearing troubles that may compromise participant's ability to participate in the study
• MRI Contraindications

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

GIP Cyceron

Caen, Calvados, 14000, France

Location

Related Publications (1)

• Coll SY, Eustache F, Doidy F, Fraisse F, Peschanski D, Dayan J, Gagnepain P, Laisney M. Avoidance behaviour generalizes to eye processing in posttraumatic stress disorder. Eur J Psychotraumatol. 2022 Apr 20;13(1):2044661. doi: 10.1080/20008198.2022.2044661. eCollection 2022.

  PMID: 35479300 DERIVED

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Interventions

Neuropsychological Tests; Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities; Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Vincent de La Sayette, MD

  University Hospital, Caen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 20, 2016
• First Posted: June 22, 2016
• Study Start: June 13, 2016
• Primary Completion: June 12, 2017
• Study Completion: December 16, 2025
• Last Updated: February 18, 2026

Record last verified: 2026-02

Locations

FR (1)