Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle Glaucoma

NCT02805231 | Completed

• 1 other identifier: tjykdxykyy4
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele.Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique.

Conditions

Primary Open- Angle Glaucoma

Outcome Measures

Primary Outcomes (1)

• gene polymorphisms of vitamin D receptor

  1 day visit

Study Arms (2)

primary open-angle glaucoma patients

vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in primary open-angle glaucoma patients.

Other: Vitamin D receptor polymorphic analysis

randomly age-matched people

vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in randomly age-matched people.

Other: Vitamin D receptor polymorphic analysis

Interventions

Vitamin D receptor polymorphic analysis OTHER

primary open-angle glaucoma patients; randomly age-matched people

Eligibility Criteria

• Age: 55 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

primary open-angle glaucoma patients and randomly age-matched people as controls in the Han population of Tianjin China

You may qualify if:

• intraocular pressure greater than 22 mmHg with two or more medications wide anterior chamber angle glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

You may not qualify if:

• the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma high myopia macular degeneration other ocular diseases a known history of systemic diseases and administration of vitamin D3 or other analog

Sponsors & Collaborators

• Lv Yingjuan: lead
• Tianjin Medical University Eye Hospital: collaborator

Study Sites (1)

Tianjin Medical University Eye Hospital

Tianjin, Tianjin Municipality, 300384, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

ApaI and Tru9I Polymorphisms

MeSH Terms

Conditions

Glaucoma, Open-Angle

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: department of ophthamology

Study Record Dates

• First Submitted: June 15, 2016
• First Posted: June 17, 2016
• Study Start: July 1, 2013
• Primary Completion: December 1, 2014
• Study Completion: March 1, 2015
• Last Updated: January 10, 2017

Record last verified: 2017-01

Locations

CN (1)