Study on Cardiovascular Health, Nutrition and Frailty in Older Adults in Spain

NCT02804672 | Completed

• 1 other identifier: Seniors-ENRICA
• Study Type: observational
• Target: 1,566
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the association between ideal cardiovascular health, diet and other lifestyles, biological risk factors, either well-established or emergent, and the risk of frailty in older adults, throughout different waves (2008-10, 2012 and 2015 -16).

Conditions

Physical Disability; Cardiovascular Risk Factors

Keywords

Cardiovascular health; Diet; Functional limitations; Frailty; Older adults

Outcome Measures

Primary Outcomes (1)

• Change from baseline in Frailty

  Method of assessment: Fried criteria

  3 years

Secondary Outcomes (1)

• Change from baseline in Cardiovascular health

  3 years

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community-living individuals in Spain aged 60 years or older.

You may qualify if:

• Non-institutionalized Spanish resident
• years and over

You may not qualify if:

• None

Sponsors & Collaborators

• Universidad Autonoma de Madrid: lead

Study Sites (1)

Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid

Madrid, 28029, Spain

Location

Related Publications (11)

• Banegas JR, de la Cruz JJ, Graciani A, Lopez-Garcia E, Gijon-Conde T, Ruilope LM, Rodriguez-Artalejo F. Impact of Ambulatory Blood Pressure Monitoring on Reclassification of Hypertension Prevalence and Control in Older People in Spain. J Clin Hypertens (Greenwich). 2015 Jun;17(6):453-61. doi: 10.1111/jch.12525. Epub 2015 Mar 16.

  PMID: 25779903 RESULT

• Garcia-Esquinas E, Graciani A, Guallar-Castillon P, Lopez-Garcia E, Rodriguez-Manas L, Rodriguez-Artalejo F. Diabetes and risk of frailty and its potential mechanisms: a prospective cohort study of older adults. J Am Med Dir Assoc. 2015 Sep 1;16(9):748-54. doi: 10.1016/j.jamda.2015.04.008. Epub 2015 May 16.

  PMID: 25986874 RESULT

• Lana A, Rodriguez-Artalejo F, Lopez-Garcia E. Dairy Consumption and Risk of Frailty in Older Adults: A Prospective Cohort Study. J Am Geriatr Soc. 2015 Sep;63(9):1852-60. doi: 10.1111/jgs.13626. Epub 2015 Aug 27.

  PMID: 26311353 RESULT

• Sandoval-Insausti H, Perez-Tasigchana RF, Lopez-Garcia E, Garcia-Esquinas E, Rodriguez-Artalejo F, Guallar-Castillon P. Macronutrients Intake and Incident Frailty in Older Adults: A Prospective Cohort Study. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1329-34. doi: 10.1093/gerona/glw033. Epub 2016 Mar 4.

  PMID: 26946103 RESULT

• Graciani A, Garcia-Esquinas E, Lopez-Garcia E, Banegas JR, Rodriguez-Artalejo F. Ideal Cardiovascular Health and Risk of Frailty in Older Adults. Circ Cardiovasc Qual Outcomes. 2016 May;9(3):239-45. doi: 10.1161/CIRCOUTCOMES.115.002294. Epub 2016 May 10.

  PMID: 27166207 RESULT

• Vazquez-Fernandez A, Caballero FF, Yevenes-Briones H, Struijk EA, Baylin A, Fung TT, Lopez-Garcia E. Plant and Animal Protein Intake and Transitions From Multimorbidity to Frailty and Mortality in Older Adults. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13729. doi: 10.1002/jcsm.13729.

  PMID: 39971333 DERIVED

• Marcos-Delgado A, Yevenes-Briones H, Fernandez-Villa T, Martin-Sanchez V, Guallar-Castillon P, Rodriguez-Artalejo F, Lopez-Garcia E. Association between diet quality and malnutrition: pooled results from two population-based studies in older adults. BMC Geriatr. 2024 May 10;24(1):417. doi: 10.1186/s12877-024-04984-5.

  PMID: 38730363 DERIVED

• Delgado-Velandia M, Maroto-Rodriguez J, Ortola R, Garcia-Esquinas E, Rodriguez-Artalejo F, Sotos-Prieto M. Plant-Based Diets and All-cause and Cardiovascular Mortality in a Nationwide Cohort in Spain: The ENRICA Study. Mayo Clin Proc. 2022 Nov;97(11):2005-2015. doi: 10.1016/j.mayocp.2022.06.008.

  PMID: 36333014 DERIVED

• Sotos-Prieto M, Ortola R, Lopez-Garcia E, Rodriguez-Artalejo F, Garcia-Esquinas E. Adherence to the Mediterranean Diet and Physical Resilience in Older Adults: The Seniors-ENRICA Cohort. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):505-512. doi: 10.1093/gerona/glaa277.

  PMID: 33152061 DERIVED

• Garcia-Esquinas E, Rodriguez-Sanchez I, Ortola R, Lopez-Garcia E, Caballero FF, Rodriguez-Manas L, Banegas JR, Rodriguez-Artalejo F. Gender Differences in Pain Risk in Old Age: Magnitude and Contributors. Mayo Clin Proc. 2019 Sep;94(9):1707-1717. doi: 10.1016/j.mayocp.2019.03.034.

  PMID: 31486377 DERIVED

• Sandoval-Insausti H, Blanco-Rojo R, Graciani A, Lopez-Garcia E, Moreno-Franco B, Laclaustra M, Donat-Vargas C, Ordovas JM, Rodriguez-Artalejo F, Guallar-Castillon P. Ultra-processed Food Consumption and Incident Frailty: A Prospective Cohort Study of Older Adults. J Gerontol A Biol Sci Med Sci. 2020 May 22;75(6):1126-1133. doi: 10.1093/gerona/glz140.

  PMID: 31132092 DERIVED

MeSH Terms

Conditions

Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Fernando Rodríguez-Artalejo, MD, PhD

  Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid

  PRINCIPAL INVESTIGATOR

• Jose R Banegas, MD, PhD

  Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Preventive Medicine and Public Health

Study Record Dates

• First Submitted: June 14, 2016
• First Posted: June 17, 2016
• Study Start: March 1, 2008
• Primary Completion: October 1, 2010
• Study Completion: June 1, 2017
• Last Updated: May 1, 2019

Record last verified: 2019-04

Locations

ES (1)