The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study

NCT02801643 | Completed

• 1 other identifier: PET/MR Pilot
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

The present study would be the first to investigate the relationship between reward- and or social stimuli-induced dopamine (DA) release and neural function using a combined PET/fMRI approach. Data from this project conducted in healthy subjects will provide preliminary data for a larger grant application to study patient populations with known abnormalities in DA including schizophrenia, major depressive, substance use, and eating disorders.

Conditions

Healthy

Keywords

PET; dopamine; fMRI; reward

Outcome Measures

Primary Outcomes (3)

• Dopamine receptor binding potential

  changes in dopamine receptor binding potential will be measured during and after a reward task or social stimulus task

  1-3 weeks

• Resting state fMRI

  Resting state functional connectivity will be measured using fMRI

  1-3 weeks

• Event-related potential (ERP) during reward

  ERP during a reward task is measured

  1-3 weeks

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

20 subjects (ages 18-45 years) will be included. Male and female representation will be about equal. No ethnic/racial/gender group is excluded.

You may qualify if:

• Healthy men and women age 18-45 who have the capacity to consent to the protocol.
• Ability to understand and follow instructions and oriented to name, time, and place.
• A negative urine pregnancy and toxicology screen
• Willingness to abstain from using aspirin, NSAIDs, or anticoagulants during the study

You may not qualify if:

• Left-handed or ambidextrous
• History of seizures
• History of strokes
• Clinically significant, uncontrolled liver, kidney, cardiac, or pulmonary disease
• Terminal medical diagnosis consistent with survival \< 1 year
• Serious mental impairment. Mini mental state exam of \< 23/30
• Current or past DSM-IV Axis I or neurologic disorders
• Actively abusing substances, including alcohol (regular alcohol use during the past 6 months equal to or greater than 16 cans of beer per week or equivalent; use of street drugs or regular tobacco use during the past 6 months)
• Unstable medical condition (≥ 3 months), or serious medical illnesses during the past three months (e.g., serious infections)
• Unexplained loss of consciousness; history of traumatic brain injury involving loss of consciousness greater than 2 minutes
• Currently pregnant or breastfeeding, sexually active and of child-bearing potential and not using adequate contraceptive methods
• Childbirth or miscarriage during past 6 months, breastfeeding within 6 months of recruitment
• Allergic to latex and/or study pharmaceuticals
• Diabetes and/or unable to fast for up to 7 hours
• Unable to lie comfortably in the scanner for up to 4 consecutive hours

Sponsors & Collaborators

• Stony Brook University: lead

Study Sites (1)

Health Sciences Center

Stony Brook, New York, 11794, United States

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Psychiatry

Study Record Dates

• First Submitted: June 13, 2016
• First Posted: June 16, 2016
• Study Start: June 1, 2016
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: April 17, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)