NCT02799693

Brief Summary

This is a single-arm non-randomized prospective observational cohort study to assess the outcomes of patients undergoing intramural needle catheter ablation of recurrent ventricular tachycardia that has failed antiarrhythmic drug therapy and standard radiofrequency (RF) catheter ablation. Following ablation, patients will be monitored for 6 months. The duration of the study is up to 4 years.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jul 2016

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 2, 2016

Completed
13 days until next milestone

First Posted

Study publicly available on registry

June 15, 2016

Completed
16 days until next milestone

Study Start

First participant enrolled

July 1, 2016

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 5, 2018

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2018

Completed
Last Updated

March 15, 2022

Status Verified

March 1, 2022

Enrollment Period

1.8 years

First QC Date

June 2, 2016

Last Update Submit

March 14, 2022

Conditions

Keywords

Catheter AblationVentricular TachycardiaIntramural Needle Catheter

Outcome Measures

Primary Outcomes (2)

  • Freedom from hospitalization for recurrent VT during 6 months following ablation

    Control of VT as defined by: freedom from hospitalization for recurrent VT during the 6 months following ablation

    6 months

  • Absence of serious adverse events attributable to the procedure which occur within 30 days of the ablation procedure

    Absence of all serious adverse events that are potentially procedure related and occur within 30 days of the ablation procedure.

    6 months

Secondary Outcomes (20)

  • Acute Procedural Success

    6 hours

  • Acute procedural complications

    24 hours

  • Number of inducible VT morphologies

    6 hours

  • ICD therapy - shocks

    3 months

  • ICD therapy - shocks

    6 months

  • +15 more secondary outcomes

Study Arms (1)

Recurrent VT failing RF ablation

Patients undergoing intramural needle catheter ablation of recurrent monomorphic ventricular tachycardia who have failed prior attempted radiofrequency catheter ablation.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with recurrent ventricular tachycardia who have failed radiofrequency catheter ablation who are undergoing intramural needle catheter ablation procedures.

You may qualify if:

  • Patients undergoing catheter ablation using the needle ablation catheter for ventricular arrhythmias.

You may not qualify if:

  • Patient refusal to participate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

QEII Health Sciences Centre

Halifax, Nova Scotia, B3H 3A7, Canada

Location

MeSH Terms

Conditions

Tachycardia, Ventricular

Condition Hierarchy (Ancestors)

TachycardiaArrhythmias, CardiacHeart DiseasesCardiovascular DiseasesCardiac Conduction System DiseasePathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • John Sapp, MD FRCPC

    Nova Scotia Health Authority

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
MD FRCPC FRHS

Study Record Dates

First Submitted

June 2, 2016

First Posted

June 15, 2016

Study Start

July 1, 2016

Primary Completion

April 5, 2018

Study Completion

May 30, 2018

Last Updated

March 15, 2022

Record last verified: 2022-03

Data Sharing

IPD Sharing
Will not share

Locations