Reasons for Prehospital Delay in Patients With Acute Ischemic Stroke

NCT02798770 | Completed

• 1 other identifier: UBE-15/64
• Study Type: observational
• Target: 337
• Locations: 1 country
• Sites: 1

Brief Summary

Ischemic stroke is the leading cause of acquired disability among adults, and one of the main causes of death. In Switzerland, the approved time window for stroke treatment with intravenous thrombolysis after symptom onset is 4.5 h. Even within the 4.5 h time-window, however, the benefit of treatment strongly decreases as time passes. Moreover, only around 10% patients receive thrombolytic treatment, since patients with stroke arrive too late to the hospital (prehospital delay). Despite efforts to educate the community on the symptom of stroke, prehospital delay did not decrease over time, and the reasons remain incompletely understood. Prehospital delay reduces the proportion of patients with ischemic stroke treated with thrombolysis, and reduces the odds of favorable outcome among the minority treated with thrombolysis. This prospective cohort study aims at understanding the causes of prehospital delay among patients with acute ischemic stroke. Trained study-nurses will interview, at the bedside, patients and proxies along a standardized questionnaire on prehospital delay. Avoiding modificables causes of prehospital delay may increase the thrombolysis rate and improve outcomes after stroke.

Conditions

Acute Ischemic Stroke

Outcome Measures

Primary Outcomes (1)

• Prehospital Delay between between Stroke Onset and Admission to the Hospital as assessed by In-Person Interview

  Prehospital delay will be assessed by asking the Patient or witnesses how long the time interval between stroke onset and Hospital Admission is. For instance, if stroke symptoms have onset today at 3:00 PM and the Patient gets admitted today at 4:00 PM, prehospital delay is 1 hour.

  an average of 1 hour

Study Arms (1)

Stroke Center Basel

Other: No Intervention Foreseen

Interventions

No Intervention Foreseen OTHER

Stroke Center Basel

Eligibility Criteria

• Age: 17 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with an acute ischemic stroke hospitalized in the Stroke Center of the University Hospital Basel.

You may qualify if:

• Patients with an acute ischemic stroke hospitalized in the Stroke Center of the University Hospital Basel.

You may not qualify if:

• Patient not able to answer the in-person, bedside questionnaire asked by a trained study Nurse.
• Patient not willing to participate to the study

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Study Sites (1)

Stroke Center University Hospital Basel

Basel, 4031, Switzerland

Location

Related Publications (1)

• Fladt J, Meier N, Thilemann S, Polymeris A, Traenka C, Seiffge DJ, Sutter R, Peters N, Gensicke H, Fluckiger B, de Hoogh K, Kunzli N, Bringolf-Isler B, Bonati LH, Engelter ST, Lyrer PA, De Marchis GM. Reasons for Prehospital Delay in Acute Ischemic Stroke. J Am Heart Assoc. 2019 Oct 15;8(20):e013101. doi: 10.1161/JAHA.119.013101. Epub 2019 Oct 2.

  PMID: 31576773 DERIVED

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD MSc Priv. Doz.

Study Record Dates

• First Submitted: June 2, 2016
• First Posted: June 14, 2016
• Study Start: August 1, 2015
• Primary Completion: November 1, 2017
• Study Completion: November 1, 2017
• Last Updated: October 10, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will share

Locations

CH (1)