Optical Coherence Tomography in STEMI
Plaque Evaluation by Optical Coherence Tomography and Its Association With Microvascular Obstruction in Reperfused STEMI Patients - The POMS Study
1 other identifier
observational
35
1 country
1
Brief Summary
The overall objective of this research proposal is to use OCT to investigate those morphological culprit plaque characteristics associated with the risk of developing MVO in reperfused STEMI patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Feb 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2016
CompletedFirst Submitted
Initial submission to the registry
May 31, 2016
CompletedFirst Posted
Study publicly available on registry
June 6, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2018
CompletedJune 6, 2016
May 1, 2016
1.9 years
May 31, 2016
May 31, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
All cause mortality
Two years
Study Arms (1)
STEMI patients
The patients presenting with a STEMI and undergoing PPCI will be screened and approached to participate in this study. All patients to do Optical Coherence Tomography (OCT), Index of Microcirculatory Resistance (IMR) and Cardiac MRI.
Interventions
Special camera to study part of your heart that was affected
Special wire to study part of your heart that was affected
Eligibility Criteria
The patients presenting with a STEMI and undergoing PPCI will be screened and approached to participate in this study.
You may qualify if:
- Confirmed STEMI as per the in-charge consultant based on presenting history, ECG and angiogram findings.
- \< 12 hours of onset of chest pain.
- Ability to provide informed consent
You may not qualify if:
- Previous myocardial infarction or coronary artery bypass graft surgery
- Cardiac arrest or cardiogenic shock
- Inability to advance the OCT catheter or to obtain good image quality
- Ostial lesions
- Significant renal impairment
- Contraindications for cardiac MRI
- Contraindication for adenosine (for IMR measurement)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Heart Centre Singapore
Singapore, Singapore, 169609, Singapore
Biospecimen
Blood samples will be collected from all participants.
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Derek Hausenloy
National Heart Centre Singapore
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 31, 2016
First Posted
June 6, 2016
Study Start
February 1, 2016
Primary Completion
January 1, 2018
Study Completion
January 1, 2018
Last Updated
June 6, 2016
Record last verified: 2016-05
Data Sharing
- IPD Sharing
- Will not share