Comparison of Day 19 and Day 20 Artificial FET

NCT02788097 | Terminated Results

• 1 other identifier: AntalyaIVF
• Study Type: interventional
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

In recent artificial frozen embryo transfers (FET) in which blastocysts vitrified on day 4 of culture and transferred on P+4, with blastocysts traditionally transferred on P+5, a high rate of implantation has been observed. In addition, a greater number of these implantations resulted in clinical pregnancies (i.e., a conceptus with normal fetal heart activity). In this prospective randomised control study, the investigators will investigate whether this increased viability, is due either to embryo quality, endometrial receptivity, or a combination of the two factors by randomizing the transfer of day 5 blastocysts to P+4 or P+5.

Conditions

Progesterone Induced Endometrial Receptivity

Keywords

blastocysts; progesterone; implantation; artificial frozen embryo transfer

Outcome Measures

Primary Outcomes (1)

• Biochemical Pregnancy

  \>30IU/L of serum βhCG on day 14 of cycle

  1 year

Study Arms (2)

Progesterone + 4

EXPERIMENTAL

the transfer of day 5 blastocyst on the 5th day of progesterone supplementation

Procedure: Progesterone supplementation

Progesterone + 5

ACTIVE COMPARATOR

the transfer of day 5 blastocysts on the 6th day of progesterone supplementation

Procedure: Progesterone supplementation

Interventions

Progesterone supplementation PROCEDURE

artificial frozen embryo transfers

Progesterone + 4; Progesterone + 5

Eligibility Criteria

• Age: 19 Years - 42 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• a freeze-all cycle

You may not qualify if:

• patients who do not consent
• patients who retract their consent
• patients with day 4 blastocysts frozen
• patients with no blastocysts frozen

Sponsors & Collaborators

• Antalya IVF: lead

Study Sites (1)

Antalya IVF

Antalya, Antalya, 07080, Turkey (Türkiye)

Location

Related Publications (3)

• Fauser BC, Devroey P. Reproductive biology and IVF: ovarian stimulation and luteal phase consequences. Trends Endocrinol Metab. 2003 Jul;14(5):236-42. doi: 10.1016/s1043-2760(03)00075-4.

  PMID: 12826330 BACKGROUND

• van de Vijver A, Polyzos NP, Van Landuyt L, Mackens S, Stoop D, Camus M, De Vos M, Tournaye H, Blockeel C. What is the optimal duration of progesterone administration before transferring a vitrified-warmed cleavage stage embryo? A randomized controlled trial. Hum Reprod. 2016 May;31(5):1097-104. doi: 10.1093/humrep/dew045. Epub 2016 Mar 22.

  PMID: 27005893 BACKGROUND

• Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011 Jun;26(6):1270-83. doi: 10.1093/humrep/der037. Epub 2011 Apr 18.

  PMID: 21502182 BACKGROUND

Results Point of Contact

• Title: Kevin Coetzee
• Organization: Antalya IVF

kevincoetzee61@yahoo.co.nz

090 242 345 4700

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Scientific advisor

Study Record Dates

• First Submitted: May 25, 2016
• First Posted: June 2, 2016
• Study Start: May 1, 2016
• Primary Completion: October 1, 2016
• Study Completion: October 1, 2016
• Last Updated: February 3, 2017
• Results First Posted: December 8, 2016

Record last verified: 2016-12

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)