Study of Progression of Community Acquired Pneumonia in the Hospital
PROGRESS
Study of Progression of Hospitalized Community Acquired Pneumonia - Genetic Resistance and Susceptibility for the Evolution of Severe Sepsis
1 other identifier
observational
2,309
2 countries
64
Brief Summary
Pneumonia is a common infectious disease of the lung, often requiring treatment in the hospital. Clinical scoring systems are available, identifying patients not requiring hospitalization. However, the course of disease of patients in the hospital remains hard to predict. While most patients will recover quickly, some will, despite appropriate treatment, develop a severe course leading to sepsis and systemic responses resulting in organ dysfunction. The PROGRESS study aims to identify clinical, genetic, and other molecular markers and combinations thereof predicting a severe course of pneumonia in the hospital. Such predictors will, for instance, support decisions on earlier transfer of patients to intensive care and thus improving outcome.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2009
Longer than P75 for all trials
64 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 25, 2009
CompletedFirst Submitted
Initial submission to the registry
May 19, 2016
CompletedFirst Posted
Study publicly available on registry
May 25, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2022
CompletedOctober 17, 2022
October 1, 2022
12.8 years
May 19, 2016
October 14, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Worst measure of disease severity
Disease severity is operationalized by the Sequential Organ Failure Assessment (SOFA-score).
Between enrollment and day six
Secondary Outcomes (5)
All cause mortality
up to one year after enrolment
disease-specific mortality
up to one year after enrolment
duration of hospitalization
up to one year after enrolment
duration of intensive care treatment
up to one year after enrolment
duration of ventilator assisted breathing
up to one year after enrolment
Eligibility Criteria
Adult patients hospitalized for treatment of community acquired pneumonia. Patients can be enrolled in general care, intensive care, and in emergency departments.
You may qualify if:
- Hospitalization with community acquired pneumonia (CAP) confirmed by pulmonary infiltrate in chest radiograph
- Working diagnosis of CAP by enrolling physician
- Adult patient \>= 18 years of age
- Valid informed consent form
- At least 2 out of the five following clinical symptoms:
- Fever
- Cough
- Purulent sputum
- Shortness of breath or need for respiratory support
- Crackling or rales on auscultation, dullness to percussion, or bronchial breathing
You may not qualify if:
- Participation in this study at an earlier time
- Hospitalization for any reason within 28 days prior to hospitalization for the current episode of CAP
- More than 48 hours in the hospital before enrollment
- Pregnancy
- Breastfeeding
- Decision on limitation of therapy before enrollment
- Known HIV infection or AIDS
- Anti-tumor treatment within the past six months
- Post-stenotic pneumonia in conjunction with bronchial carcinoma
- Therapy with corticosteroids ≥ 20mg for ≥ 14 days before enrollment
- Non-steroidal immunosuppressive therapy within the past six months
- Cytostatic therapy within the past six months
- Radiation therapy within the past six months
- Bone marrow transplant received
- Respiratory support at home via tracheostoma
- +8 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Sepslead
- University of Leipzigcollaborator
- Jena University Hospitalcollaborator
- University of Giessencollaborator
- University Medicine Greifswaldcollaborator
- Charite University, Berlin, Germanycollaborator
- German Federal Ministry of Education and Researchcollaborator
Study Sites (64)
LKH-Univ. Klinikum Graz, UKIM Pulmologie
Graz, 8036, Austria
Allgemeines Krankenhaus der Stadt Linz, Abteilung Lungenheilkunde
Linz, 4021, Austria
Universitätsklinikum Aachen, Med. Klinik I (Pneumologie)
Aachen, 52057, Germany
Evangel. Krankenhausverein, Luisenhospital, Lungenzentrum
Aachen, 52064, Germany
Krankenhaus Angermünde, Klinik f. Innere Medizin / Pneumologie
Angermünde, 16278, Germany
Krankenhaus Bad Arolsen GmbH, Innere Medizin (Herz-, Kreislauf- u. Lungendiagnostik)
Bad Arolsen, 34454, Germany
Evangelisches Krankenhaus Bad Dürkheim, Innere Medizin
Bad Dürkheim, 67098, Germany
Hochtaunus-Kliniken, Medizinische Klinik III
Bad Homburg, 61348, Germany
Lungenklinik Ballenstedt/Harz gGmbH, Ev. Fachkrankenhaus f. Lungenkrankheiten
Ballenstedt, 06493, Germany
Charité - Universitätsmedizin Berlin, Zentrum Anästhesiologie und Intensivmedizin
Berlin, 12203, Germany
Vivantes Netzwerk f. Gesundheit GmbH Vivantes Klinikum Neukölln, Klinik f. Innere Med. - Pneumologie u.Infektiologie - Thoraxzentrum
Berlin, 12351, Germany
HELIOS Klinikum Berlin-Buch, Interdisziplinäres Notfallzentrum mit Rettungsstelle
Berlin, 13125, Germany
Evangelisches Geriatriezentrum Berlin
Berlin, 13347, Germany
Charité - Universitätsmedizin Berlin, Medizinische Klinik m. S. Infektiologie und Pneumologie
Berlin, 13353, Germany
Humboldt-Klinikum Vivantes, Kardiologie und kons. Intensivmedizin
Berlin, 13509, Germany
Vivantes Klinikum Spandau, Kard., Pneum. und kons. Intensivmedizin
Berlin, 13585, Germany
Gemeinschaftskrankenhaus Havelhöhe, Kardio-Pneumologie
Berlin, 14089, Germany
Berufsgenossenschaftl. Universitätsklinikum Bergmannsheil GmbH, Klinik f. Pneumologie, Allergologie u. Schlafmedizin
Bochum, 44789, Germany
Evangelische Kliniken Bonn, Betriebsstätte Johanniter Krankenhaus, Innere Medizin II
Bonn, 53113, Germany
Med. Klinik d. Forschungszentrum Borstel, Fachkrankenhaus f. Lungenerkrankungen, Infektionen u. Allergien
Borstel, 23845, Germany
Evangelisches Krankenhaus Kalk gGmbH, Innere Medizin / Pneumologie
Cologne, 51103, Germany
Städt. Klinikum Dessau, Innere Medizin
Dessau, 06847, Germany
Klinikum Dortmund gGmbH, Medizinische Klinik (Pneumologie / Infektiologie)
Dortmund, 44145, Germany
Knappschaftskrankenhaus Dortmund, Klinik für Pneumologie
Dortmund, 44309, Germany
Universitätsklinikum Carl Gustav Carus, TU Dresden, Medizinische Klinik 1 - Abteilung Pneumologie
Dresden, 01307, Germany
SRH Wald-Klinikum Gera gGmbH, Medizinische Klinik 2
Gera, 07548, Germany
Uniklinikum Greifswald, Zentrum für Innere Medizin B
Greifswald, 17489, Germany
Krankenhaus Martha-Maria Halle-Dölau, Klinik für Innere Medizin I
Halle, 06120, Germany
Universitätsklinikum Halle (Saale), Klinik für Innere Medizin III (Kardiologie, Pneumologie, Intensivmedizin, Angiologie)
Halle, 06120, Germany
Universitätsklinikum Hamburg Eppendorf, Onkologisches Zentrum, Pneumologische Studienzentrale
Hamburg, 20246, Germany
ASKLEPIOS Klinik Wandsbek, 1. Medizinische Abteilung
Hamburg, 22043, Germany
Medizinische Hochschule Hannover, Klinik für Pneumologie
Hanover, 30652, Germany
Klinkum Heidenheim, Medizinische Klinik II & Innere Intensiv
Heidenheim, 89522, Germany
Kliniken d. Main-Taunus-Kreises, Klinik f. Pneumologie u. Allg. Innere Medizin
Hofheim, 65719, Germany
Universitätsklinikum des Saarlandes, Innere Medizin V
Homburg/Saar, 66421, Germany
Universitätsklinikum Jena, Klinik für Anästhesiologie und Intensivtherapie
Jena, 07747, Germany
Universitätsklinikum Jena, Zentrum für Infektionsmedizin und Krankenhaushygiene, Studienabteilung
Jena, 07747, Germany
St.Vincentius-Kliniken gAG, Med. Klinik IV / Pneumologie
Karlsruhe, 76137, Germany
Universitätsklinikum Schleswig-Holstein - Campus Kiel, Medizin 1
Kiel, 24105, Germany
Universität Leipzig, Innere Medizin, Neurologie und Dermatologie, Pneumologie / Studiensekretariat
Leipzig, 04103, Germany
Klinikum St. Georg gGmbH, Klinik für Infektions-/Tropenmedizin und Nephrologie
Leipzig, 04129, Germany
Franziskus Krankenhaus Linz, Innere Abteilung
Linz, 53545, Germany
Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Med. Klinik III (Pneumologie)
Lübeck, 23538, Germany
St. Vincenz und Elisabeth Hospital Mainz, Innere Medizin
Mainz, 55130, Germany
Universitätsmedizin Mannheim, Studienkoordinierungszentrum, 1. Medizinische Klinik
Mannheim, 68167, Germany
Städtisches Klinikum München GmbH - Klinikum Harlaching, Klinik für Gastroent., Pneum., intern. Akut- u. Intensivmedizin
München, 81545, Germany
Krankenhaus München-Neuperlach, Klinik für Kardiologie, Pneumologie und Internistische Intensivmedizin
München, 81737, Germany
Universitätsklinikum Münster, Kardiologie 1
Münster, 48149, Germany
Dietrich-Bonhoeffer-Klinikum, Klinik f. Innere Medizin 2 (Abt. Pulmologie)
Neubrandenburg, 17039, Germany
Ev. Fachkrankenhaus für Atemwegserkrankungen
Neustadt, 99762, Germany
Pius-Hospital Oldenburg, Klinik f. Innere Med., Abt. f. Pneumologie
Oldenburg, 26121, Germany
Brüderkrankenhaus St. Josef, Medizinische Klinik
Paderborn, 33098, Germany
Christliches Krankenhaus Quakenbrück e. V., Med. Klinik (Abtl. Pneumologie, Allergologie, Schlafmedizin)
Quakenbrück, 49610, Germany
Universitätsklinikum Regensburg, Klinik Innere Medizin I, Intensivmedizin, Endokrinologie
Regensburg, 93053, Germany
Mathias-Spital Rheine, Klinik für Pneumologie und Thoraxonkologie
Rheine, 48431, Germany
Diakoniekrankenhaus Rotenburg(Wümme)gGmbH, Zentrum für Pneumologie
Rotenburg (Wümme), 27356, Germany
Altmark-Klinikum gGmbH, Krankenhaus Salzwedel
Salzwedel, 29410, Germany
HELIOS Kliniken Schwerin GmbH, Klinik für Internistische und Neurologische Intensivmedizin/Stroke Unit
Schwerin, 19049, Germany
Krankenhaus Bethanien gGmbH Solingen, Abt. Pneumologie
Solingen, 42699, Germany
Kreisklinik Trostberg, Innere Abteilung
Trostberg an der Alz, 83308, Germany
Universitätsklinikum Ulm, Klinik für Innere Medizin II, Sudienzentrale Innere II, Sektion Pneumologie
Ulm, 89081, Germany
HELIOS Klinikum Wuppertal, Klinik für Intensivmedizin
Wuppertal, 42283, Germany
HELIOS Klinikum Wuppertal, Pneumologie, Bergisches Lungenzentrum
Wuppertal, 42283, Germany
Missionsärztliche Klinik GmbH Würzburg, Innere Medizin (Pneumologie)
Würzburg, 97074, Germany
Related Publications (3)
Rosolowski M, Oberle V, Ahnert P, Creutz P, Witzenrath M, Kiehntopf M, Loeffler M, Suttorp N, Scholz M. Dynamics of cytokines, immune cell counts and disease severity in patients with community-acquired pneumonia - Unravelling potential causal relationships. Cytokine. 2020 Dec;136:155263. doi: 10.1016/j.cyto.2020.155263. Epub 2020 Sep 4.
PMID: 32896803DERIVEDAhnert P, Creutz P, Horn K, Schwarzenberger F, Kiehntopf M, Hossain H, Bauer M, Brunkhorst FM, Reinhart K, Volker U, Chakraborty T, Witzenrath M, Loffler M, Suttorp N, Scholz M; PROGRESS Study Group. Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study. Crit Care. 2019 Apr 4;23(1):110. doi: 10.1186/s13054-019-2316-x.
PMID: 30947753DERIVEDAhnert P, Creutz P, Scholz M, Schutte H, Engel C, Hossain H, Chakraborty T, Bauer M, Kiehntopf M, Volker U, Hammerschmidt S, Loeffler M, Suttorp N; PROGRESS study group. PROGRESS - prospective observational study on hospitalized community acquired pneumonia. BMC Pulm Med. 2016 Jul 28;16(1):108. doi: 10.1186/s12890-016-0255-8.
PMID: 27535544DERIVED
Related Links
Biospecimen
DNA from EDTA whole blood, RNA from stabilized whole blood, serum, citrate plasma, stabilized EDTA plasma, urin
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Norbert Suttorp, MD
Charite University, Berlin, Germany
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 19, 2016
First Posted
May 25, 2016
Study Start
August 25, 2009
Primary Completion
June 1, 2022
Study Completion
June 1, 2022
Last Updated
October 17, 2022
Record last verified: 2022-10
Data Sharing
- IPD Sharing
- Will share
Anonymized individual participant data will be made available after conclusion of the study. Participants can apply for clinical and molecular study data by sending structured project proposals to the PROGRESS board. The PROGRESS board will evaluate proposals for scientific quality, adherence to the limits set by patient's informed consent statements and by intellectual property regulations of the funding agency. Proposals shall not be denied without concrete reason.