The National Myelodysplastic Syndromes (MDS) Study
MDS
1 other identifier
observational
2,115
2 countries
281
Brief Summary
Multi-center study enrolling patients suspected or newly diagnosed with myelodysplastic syndromes (MDS), myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) overlap disorder, or idiopathic cytopenia of undetermined significance (ICUS). Participants will be followed long term. Clinical data, blood, and tissue samples will be collected to establish a biorepository to facilitate the study of the natural history of MDS.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2016
Longer than P75 for all trials
281 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 2, 2016
CompletedFirst Posted
Study publicly available on registry
May 17, 2016
CompletedStudy Start
First participant enrolled
June 13, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2025
CompletedFebruary 3, 2026
November 1, 2025
9.1 years
May 2, 2016
January 30, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of patients dying
Deaths will be reported on study case report forms
Through study completion, an average of 3 years
Secondary Outcomes (1)
Number of participants progressing to Acute Myeloid Leukemia (AML)
Through study completion, an average of 3 years
Study Arms (2)
Longitudinal
Participants with MDS, MDS/MPN overlap disorder, AML \<30% blasts without core binding factor or acute promyelocytic leukemia, ICUS, or at risk based on select karyotypic or genetic abnormalities
Cross-sectional
Participants who do not have MDS, MDS/MPN overlap disorder, or ICUS and have the baseline visit only
Interventions
Eligibility Criteria
Patients with suspected MDS or MDS/MPN overlap disorder who are undergoing diagnostic workup and bone marrow assessments, and patients diagnosed with MDS within 6-months of enrollment and undergoing clinical evaluation and bone marrow assessments to confirm MDS or evaluate disease status
You may qualify if:
- Suspected (e.g., persistent unexplained cytopenia, circulating peripheral blasts etc.) MDS or MDS/MPN overlap disorders and undergoing diagnostic work-up with planned bone marrow assessments, or diagnosed with de novo or therapy-related MDS within 12 months of enrollment per the World Health Organization (WHO) criteria1 and undergoing clinical evaluation and planned bone marrow assessments to confirm MDS or to evaluate disease status
- Bone marrow aspirate expected to be performed within 1 week of registration, and in all cases must be performed no later than 4 weeks after enrollment
- Age 18 or older
- If anemic without prior MDS diagnosis, B12 level, serum folate, mean corpuscular volume (MCV), red cell distribution width (RDW), ferritin, and iron studies (Iron, total iron-binding capacity (TIBC) test, and percent saturation) must be performed within prior 6 months.
You may not qualify if:
- Prior treatment for MDS at entry and through the time of the entry bone marrow aspirate
- Treatment with hematopoietic growth factors in prior 6 months
- Diagnosis of a solid tumor or hematologic malignancy within two years prior to enrollment except for in situ cancer of the skin (basal or squamous cell), cervix, bladder, breast, or prostate
- Treatment with radiation therapy in the two years prior to registration
- Non-hormonal treatment for malignancy within the two years prior to registration
- Established hereditary bone marrow failure syndrome
- Known primary diagnosis of aplastic anemia, classical paroxysmal nocturnal hemoglobinuria, amegakaryocytic thrombocytopenic purpura, or large granular lymphocyte leukemia
- Enrolled in the Connect® MDS/AML Disease Registry (NCT01688011)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (281)
Kaiser Permanente-Anaheim
Anaheim, California, 92806, United States
Kaiser Permanente-Baldwin Park
Baldwin Park, California, 91706, United States
Kaiser Permanente-Bellflower
Bellflower, California, 90706, United States
Kaiser Permanente-Fontana
Fontana, California, 92335, United States
Kaiser Permanente - South Bay
Harbor City, California, 90710, United States
Kaiser Permanente-Irvine
Irvine, California, 92618, United States
Tibor Rubin VA Medical Center
Long Beach, California, 90822, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027, United States
Kaiser Permanente-Cadillac
Los Angeles, California, 90034, United States
Va Palo Alto Health Care System
Palo Alto, California, 94304, United States
Kaiser Permanente - Panorama City
Panorama City, California, 91402, United States
Eisenhower Medical Center
Rancho Mirage, California, 92270, United States
Kaiser Permanente-Riverside
Riverside, California, 92505, United States
Kaiser Permanente-San Diego Zion
San Diego, California, 92120, United States
Veterans Affairs Medical Center - San Francisco
San Francisco, California, 94121, United States
Kaiser Permanente-San Marcos
San Marcos, California, 92078, United States
Kaiser Permanente-Woodland Hills
Woodland Hills, California, 91367, United States
Rocky Mountain Regional VA Medical Center
Aurora, Colorado, 80045, United States
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06511, United States
Yale University
New Haven, Connecticut, 06520, United States
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven, Connecticut, 06516, United States
Helen F Graham Cancer Center
Newark, Delaware, 19713, United States
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713, United States
Regional Hematology and Oncology PA
Newark, Delaware, 19713, United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718, United States
Baptist MD Anderson Cancer Center
Jacksonville, Florida, 32207, United States
Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
Lakeland Regional Health Hollis Cancer Center
Lakeland, Florida, 33805, United States
Moffitt Cancer Center
Tampa, Florida, 33612, United States
Indian River Medical Center
Vero Beach, Florida, 32960, United States
Northside Hospital
Atlanta, Georgia, 30342, United States
Augusta University Medical Center
Augusta, Georgia, 30912, United States
Atlanta VA Medical Center
Decatur, Georgia, 30033, United States
Northside Hospital - Duluth
Duluth, Georgia, 30096, United States
Northeast Georgia Medical Center-Gainesville
Gainesville, Georgia, 30501, United States
Northside Hospital - Gwinnett
Lawrenceville, Georgia, 30046, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405, United States
Suburban Hematology Oncology Associates - Snellville
Snellville, Georgia, 30078, United States
Queen's Cancer Center - POB I
Honolulu, Hawaii, 96813, United States
Queen's Medical Center
Honolulu, Hawaii, 96813, United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813, United States
University of Hawaii Cancer Center
Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-POB II
Honolulu, Hawaii, 96817, United States
OnCare Hawaii - Liliha
Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817, United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826, United States
Pali Momi Medical Center
‘Aiea, Hawaii, 96701, United States
Queen's Cancer Center - Pearlridge
‘Aiea, Hawaii, 96701, United States
Kootenai Medical Center
Coeur d'Alene, Idaho, 83814, United States
Kootenai Cancer Center
Post Falls, Idaho, 83854, United States
Kootenai Cancer Clinic
Sandpoint, Idaho, 83864, United States
Illinois CancerCare - Bloomington
Bloomington, Illinois, 61704, United States
Memorial Hospital of Carbondale
Carbondale, Illinois, 62901, United States
SIH Cancer Institute
Carterville, Illinois, 62918, United States
Centralia Oncology Clinic
Centralia, Illinois, 62801, United States
Carle on Vermilion
Danville, Illinois, 61832, United States
Decatur Memorial Hospital
Decatur, Illinois, 62522, United States
Cancer Care Specialists of Central Illinois - Decatur
Decatur, Illinois, 62568, United States
Carle Physician Group-Effingham
Effingham, Illinois, 62401, United States
Crossroads Cancer Center
Effingham, Illinois, 62401, United States
AMITA Health Alexian Brothers Medical Center
Elk Grove Village, Illinois, 60007, United States
Illinois CancerCare - Galesburg
Galesburg, Illinois, 61401, United States
AMITA Health Cancer Institute and Outpatient Center
Hinsdale, Illinois, 60521, United States
Presence Saint Mary's Hospital
Kankakee, Illinois, 60901, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938, United States
Cancer Care Specialists of O'Fallon
O'Fallon, Illinois, 62269, United States
Illinois CancerCare - Peoria
Peoria, Illinois, 61615, United States
Carle Cancer Center
Urbana, Illinois, 61801, United States
Mercy Hospital
Cedar Rapids, Iowa, 52403, United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, 50325, United States
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325, United States
Greater Regional Medical Center
Creston, Iowa, 50801, United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, 50314, United States
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, 50314, United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266, United States
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence, Kansas, 67301, United States
Cancer Center of Kansas-Kingman
Kingman, Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044, United States
Kansas Institute of Medicine Cancer and Blood Center
Lenexa, Kansas, 66219, United States
Cancer Center of Kansas - Liberal
Liberal, Kansas, 67901, United States
Cancer Center of Kansas - Newton
Newton, Kansas, 67114, United States
Cancer Center of Kansas - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina
Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152, United States
Associates In Womens Health
Wichita, Kansas, 67208, United States
Cancer Center of Kansas - Wichita Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67208, United States
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67218, United States
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156, United States
Harold Alfond Center for Cancer Care
Augusta, Maine, 04330, United States
Waldo County General Hospital
Belfast, Maine, 04915, United States
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford, Maine, 04005, United States
Stephens Memorial Hospital
Norway, Maine, 04268, United States
Penobscot Bay Medical Center
Rockport, Maine, 04856, United States
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford, Maine, 04073, United States
Maine Medical Partners-South Portland
South Portland, Maine, 01406, United States
York Hospital
York Village, Maine, 03909, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21231, United States
UM Upper Chesapeake Medical Center
Bel Air, Maryland, 21014, United States
Walter Reed National Military Medical Center
Bethesda, Maryland, 20889, United States
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655, United States
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106, United States
IHA Hematology Oncology Consultants-Brighton
Brighton, Michigan, 48114, United States
Saint Joseph Mercy Brighton
Brighton, Michigan, 48114, United States
IHA Hematology Oncology Consultants-Canton
Canton, Michigan, 48188, United States
Saint Joseph Mercy Canton
Canton, Michigan, 48188, United States
IHA Hematology Oncology Consultants-Chelsea
Chelsea, Michigan, 48118, United States
Saint Joseph Mercy Chelsea
Chelsea, Michigan, 48118, United States
Beaumont Hospital - Dearborn
Dearborn, Michigan, 48124, United States
Michigan State University Clinical Center
East Lansing, Michigan, 48824, United States
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, 49503, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 22787, United States
Spectrum Health Reed City Hospital
Reed City, Michigan, 49677, United States
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan, 48073, United States
Ascension Saint Mary's Hospital
Saginaw, Michigan, 48601, United States
Ascension Providence Hospitals - Southfield
Southfield, Michigan, 48075, United States
William Beaumont Hospital - Troy
Troy, Michigan, 48073, United States
Metro Health Hospital
Wyoming, Michigan, 49519, United States
IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, Michigan, 48197, United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601, United States
Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
Saint Luke's Hospital of Duluth
Duluth, Minnesota, 55802, United States
Essentia Health Cancer Center
Duluth, Minnesota, 55805, United States
Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, 55805, United States
Miller-Dwan Hospital
Duluth, Minnesota, 55805, United States
Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
Unity Hospital
Fridley, Minnesota, 55432, United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
Minneapolis VA Medical Center
Minneapolis, Minnesota, 55417, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416, United States
United Hospital
Saint Paul, Minnesota, 55102, United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55739, United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703, United States
Capital Region Southwest Campus
Jefferson City, Missouri, 65109, United States
Kansas City Veterans Affairs Medical Center
Kansas City, Missouri, 64128, United States
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, 65401, United States
Mercy Clinic - Rolla - Cancer and Hematology
Rolla, Missouri, 65401, United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506, United States
Mercy Hospital Springfield
Springfield, Missouri, 65804, United States
CoxHealth South Hospital
Springfield, Missouri, 65807, United States
Community Hospital of Anaconda
Anaconda, Montana, 59711, United States
Bozeman Deaconess Hospital
Bozeman, Montana, 59715, United States
Benefis Healthcare-Sletten Cancer Institute
Great Falls, Montana, 59406, United States
CHI Health Saint Francis
Grand Island, Nebraska, 68803, United States
OptumCare Cancer Care at Seven Hills
Henderson, Nevada, 89052, United States
OptumCare Cancer Care at Oakey
Las Vegas, Nevada, 89102, United States
Hope Cancer Care of Nevada
Las Vegas, Nevada, 89103, United States
OptumCare Cancer Care at Mountainview
Las Vegas, Nevada, 89128, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135, United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89148, United States
Veterans Administration New Jersey Health Care System
East Orange, New Jersey, 07018-1095, United States
Inspira Medical Center Woodbury
Woodbury, New Jersey, 08096, United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106, United States
Memorial Medical Center-Las Cruces
Las Cruces, New Mexico, 88011, United States
Maimonides Medical Center
Brooklyn, New York, 11219, United States
Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York, 14905, United States
Glens Falls Hospital
Glens Falls, New York, 12801, United States
North Shore University Hospital
Lake Success, New York, 11042, United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042, United States
Long Island Jewish Medical Center
New Hyde Park, New York, 11040, United States
Phelps Memorial Hospital Center
Sleepy Hollow, New York, 10591, United States
Montefiore Medical Center - Einstein Campus
The Bronx, New York, 10461, United States
Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
James J Peters VA Medical Center
The Bronx, New York, 10468, United States
Mission Hospital
Asheville, North Carolina, 28801, United States
Durham VA Medical Center
Durham, North Carolina, 27705, United States
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501, United States
Sanford Clinic North-Fargo
Fargo, North Dakota, 58102, United States
Sanford Broadway Medical Center
Fargo, North Dakota, 58122, United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122, United States
Cleveland Clinic Akron General
Akron, Ohio, 44307, United States
MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
Cleveland Clinic Cancer Center/Fairview Hospital
Fairview, Ohio, 44111, United States
Cleveland Clinic Cancer Center Independence
Independence, Ohio, 44131, United States
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio, 44906, United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124, United States
North Coast Cancer Care
Sandusky, Ohio, 44870, United States
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio, 44691, United States
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma, 73505, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120, United States
Kaiser Permanente Northwest
Portland, Oregon, 97227, United States
Oregon Health & Science University
Portland, Oregon, 97239, United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103, United States
Lehigh Valley Hospital-Muhlenberg
Bethlehem, Pennsylvania, 18017, United States
Geisinger Medical Center
Danville, Pennsylvania, 17821, United States
Easton Hospital
Easton, Pennsylvania, 18042, United States
Ephrata Cancer Center
Ephrata, Pennsylvania, 17522, United States
Adams Cancer Center
Gettysburg, Pennsylvania, 17325, United States
Geisinger Medical Center - Cancer Center Hazleton
Hazleton, Pennsylvania, 18201, United States
Sechler Family Cancer Center
Lebanon, Pennsylvania, 17042, United States
Geisinger Medical Oncology - Lewisburg
Lewisburg, Pennsylvania, 17837, United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
Phoenixville Hospital
Phoenixville, Pennsylvania, 19460, United States
Pottstown Hospital
Pottstown, Pennsylvania, 19464, United States
Geisinger Cancer Services - Pottsville
Pottsville, Pennsylvania, 17901, United States
Penn State Health Saint Joseph Medical Center
Reading, Pennsylvania, 19605, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711, United States
UPMC Susquehanna
Williamsport, Pennsylvania, 17701, United States
WellSpan Health-York Hospital
York, Pennsylvania, 17401, United States
Ralph H Johnson VA Medical Center
Charleston, South Carolina, 29401, United States
Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640, United States
Saint Francis Hospital
Greenville, South Carolina, 29601, United States
Prisma Health System Cancer Institute - Eastside
Greenville, South Carolina, 29605, United States
Prisma Health System Cancer Institute - Faris
Greenville, South Carolina, 29605, United States
Saint Francis Cancer Center
Greenville, South Carolina, 29607, United States
Self Regional Healthcare
Greenwood, South Carolina, 29646, United States
Prisma Health System Cancer Institute - Greer
Greer, South Carolina, 29650, United States
Prisma Health System Cancer Institute - Butternut
Reidville, South Carolina, 29605, United States
Prisma Health System Cancer Institute - Seneca
Seneca, South Carolina, 29672, United States
Spartanburg Medical Center
Spartanburg, South Carolina, 29303, United States
Prisma Health System Cancer Institute - Spartanburg
Spartanburg, South Carolina, 29307, United States
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota, 57401, United States
Monument Health Rapid City Hospital
Rapid City, South Dakota, 57701, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120, United States
Meharry Medical College
Nashville, Tennessee, 37208, United States
Dell Seton Medical Center at The University of Texas
Austin, Texas, 78701, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, 75080, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229, United States
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia, 22939, United States
MultiCare Auburn Medical Center
Auburn, Washington, 98001, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington, 98310, United States
Harrison Medical Center
Bremerton, Washington, 98310, United States
MultiCare Gig Harbor Medical Park
Gig Harbor, Washington, 98335, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, Washington, 98370, United States
MultiCare Good Samaritan Hospital
Puyallup, Washington, 98372, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
Seattle Cancer Care Alliance
Seattle, Washington, 98109, United States
University of Washington Medical Center
Seattle, Washington, 98115, United States
MultiCare Tacoma General Hospital
Tacoma, Washington, 98405, United States
West Virginia University Charleston Division
Charleston, West Virginia, 25304, United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus
Brookfield, Wisconsin, 53045, United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105, United States
Marshfield Medical Center - EC Cancer Center
Eau Claire, Wisconsin, 54701, United States
Aurora Health Center-Fond du Lac
Fontana, Wisconsin, 54937, United States
Ascension Saint Francis-Reiman Cancer Center
Franklin, Wisconsin, 53132, United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022, United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 53715, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301, United States
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53412, United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, 54601, United States
William S Middleton VA Medical Center
Madison, Wisconsin, 53705, United States
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, 53792, United States
Holy Family Memorial Hospital
Manitowoc, Wisconsin, 54220, United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143, United States
Vince Lombardi Cancer Clinic-Marinette
Marinette, Wisconsin, 54143, United States
Marshfield Medical Center - Marshfield
Marshfield, Wisconsin, 54449, United States
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215, United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53226, United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233, United States
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, 54548, United States
Ascension Mercy Hospital
Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904, United States
Ascension All Saints Hospital
Racine, Wisconsin, 53405, United States
Aurora Cancer Care-Racine
Racine, Wisconsin, 53406, United States
Marshfield Medical Center - Rice Lake
Rice Lake, Wisconsin, 54868, United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081, United States
Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin, 54482, United States
Aurora Medical Center in Summit
Summit, Wisconsin, 53066, United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241, United States
Ascension Medical Group Southeast Wisconsin-Mayfair Road
Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226, United States
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227, United States
Marshfield Clinic-Weston Center
Weston, Wisconsin, 54476, United States
Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
Related Publications (4)
Gillis N, Colin-Leitzinger C, Tang YH, Otterstatter M, Sherman S, Zhang L, Moscinski LC, Walker ME, Painter JS, Abel GA, Al Baghdadi T, Deeg HJ, Foran JM, Gore SD, Harrington AM, Kroft SH, Liu JJ, Saber W, Virani S, Bejar R, Lindsley RC, Padron E, Walter MJ, Komrojki R, DeZern AE, Sekeres MA. Clinical, Genetic, and Pathologic Variability in Myelodysplastic Syndromes and Precursor Conditions Across Race, Ethnicity, and Sex. Am J Hematol. 2026 Mar 29. doi: 10.1002/ajh.70279. Online ahead of print.
PMID: 41906220DERIVEDDeZern AE, Gillis N, Otterstatter M, Abel GA, Padron E, Deeg HJ, Al Baghdadi T, Liu JJ, Xie Z, Zhang L, Moscinski LC, Kroft SH, Harrington AM, Foran JM, Komrokji RS, Starczynowski DT, Gore SD, Saber W, Bejar R, Lindsley RC, Sherman S, Lee C, DiFronzo NL, Walter MJ, Sekeres MA. A novel approach to defining progression in MDS and precursor myeloid conditions in The MDS Natural History Study. Blood Adv. 2026 Feb 11:bloodadvances.2025018770. doi: 10.1182/bloodadvances.2025018770. Online ahead of print.
PMID: 41671442DERIVEDAbel GA, Hebert D, Lee C, Rollison D, Gillis N, Komrokji R, Foran JM, Liu JJ, Al Baghdadi T, Deeg J, Gore S, Saber W, Wilson S, Otterstatter M, Thompson J, Borchert C, Padron E, DeZern A, Cella D, Sekeres MA. Health-related quality of life and vulnerability among people with myelodysplastic syndromes: a US national study. Blood Adv. 2023 Jul 25;7(14):3506-3515. doi: 10.1182/bloodadvances.2022009000.
PMID: 37146263DERIVEDDeZern AE, Goll JB, Lindsley RC, Bejar R, Wilson SH, Hebert D, Deeg J, Zhang L, Gore S, Al Baghdadi T, Maciejewski J, Liu J, Padron E, Komrojki R, Saber W, Abel G, Kroft SH, Harrington A, Grimes T, Reed H, Fulton RS, DiFronzo NL, Gillis N, Sekeres MA, Walter MJ. Utility of targeted gene sequencing to differentiate myeloid malignancies from other cytopenic conditions. Blood Adv. 2023 Jul 25;7(14):3749-3759. doi: 10.1182/bloodadvances.2022008578.
PMID: 36947201DERIVED
Related Links
Biospecimen
bone marrow, peripheral blood, serum, plasma, eyebrow hairs with attached follicles, buccal cells, skin biopsy
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Mikkael Sekeres, MD, MS
University of Miami
- STUDY CHAIR
Amy DeZern, MD, MHS
Johns Hopkins University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 9 Years
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 2, 2016
First Posted
May 17, 2016
Study Start
June 13, 2016
Primary Completion
July 31, 2025
Study Completion
December 31, 2025
Last Updated
February 3, 2026
Record last verified: 2025-11