Estimating Quality of Life in People With Asthma
Estimating the Loss in Quality of Life Associated With an Asthma Related Crisis Event (ESQUARE)
1 other identifier
observational
121
1 country
3
Brief Summary
The aim of this project is to estimate the quality of life for people with asthma and specifically the loss in quality of life associated with an asthma-related crisis event (accident and emergency (A\&E) attendance or admission).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2016
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2016
CompletedFirst Submitted
Initial submission to the registry
May 5, 2016
CompletedFirst Posted
Study publicly available on registry
May 13, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 25, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
July 25, 2017
CompletedMay 3, 2018
October 1, 2016
1.2 years
May 5, 2016
May 2, 2018
Conditions
Outcome Measures
Primary Outcomes (4)
EuroQol 5 Dimensions 5 Level (EQ-5D-5L)
A generic quality of life questionnaire
Once a week from baseline until week 8
Asthma Quality of Life Questionnaire (AQLQ)
A disease-specific quality of life questionnaire
Once a month from baseline to week 8
Peak flow and asthma symptom diary
Assessment of peak expiratory flow and asthma symptoms
Every day from baseline to week 8
Time Trade-Off
Assessment of quality of life. Completed at Norfolk and Norwich University Hospital only.
Once a month from baseline to week 8
Secondary Outcomes (1)
Productivity Questionnaire
Week 4
Study Arms (1)
Asthma
All participants will have an asthma-related crisis event due to an asthma exacerbation that resulted in A\&E attendance and/or hospital admission.
Eligibility Criteria
Asthma patients who have an asthma-related crisis event (attended A\&E or have been admitted to hospital).
You may qualify if:
- Male or Female 18 years old and over
- Has asthma alone, or asthma with Chronic Obstructive Pulmonary Disease (COPD) or asthma with a respiratory infection
- Speaks English
- Not in need of help from carer / guardian to complete questionnaires
- Not hypoxemic
- Not participated in the study before
- Able to give informed consent
You may not qualify if:
- Younger than 18 years old
- Does not speak English
- Has participated in the study before
- Remains hypoxemic despite oxygen therapy
- Impaired capacity to consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Norfolk and Norwich University Hospital
Norwich, Select A County, NR4 7TJ, United Kingdom
Aberdeen Royal Infirmary
Aberdeen, AB25 2ZN, United Kingdom
Queen Elizabeth Hospital Birmingham
Birmingham, B15 2GW, United Kingdom
Related Publications (1)
Crossman-Barnes CJ, Sach T, Wilson A, Barton G. Estimating loss in quality of life associated with asthma-related crisis events (ESQUARE): a cohort, observational study. Health Qual Life Outcomes. 2019 Apr 11;17(1):58. doi: 10.1186/s12955-019-1138-5.
PMID: 30971261DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christina-Jane Crossman-Barnes, BSc, MSc
University of East Anglia
- PRINCIPAL INVESTIGATOR
Andrew Wilson, MD FRCP
University of East Anglia
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 5, 2016
First Posted
May 13, 2016
Study Start
May 1, 2016
Primary Completion
July 25, 2017
Study Completion
July 25, 2017
Last Updated
May 3, 2018
Record last verified: 2016-10