Early Periprosthetic Joint Infection and Outcome Debridement, Antibiotics and Implant Retention

NCT02771639 | Completed

• 1 other identifier: DAIR_SM
• Study Type: observational
• Target: 736
• Locations: 0 countries
• Sites: N/A

Brief Summary

Introduction Periprosthetic joint infection (PJI) is a severe complication to hip arthroplasty for femoral neck fractures (FNF). Debridement, antibiotics and implant retention (DAIR) is recommended in early PJI in association with stable implants. Few studies have evaluated the outcome of DAIR in this fragile population.The purpose of this study was to analyze risk factors for PJI and the short-term outcome of DAIR in FNF patients treated with a hip arthroplasty. Methods A consecutive series of patients had been treated with either a total hip arthroplasty or a hemi hip arthroplasty for a displaced FNF at our institution. Data were retrospective analysed.

Conditions

Femoral Neck Fracture; Infection

Keywords

Hip arthroplasty; periprosthetic joint infection; outcome

Outcome Measures

Primary Outcomes (1)

• Rate of periprosthetic joint infection

  The incidence of periprosthetic joint infection

  1 year

Secondary Outcomes (1)

• The rate of healed periprosthetic joint infections after treatment with surgical debridement.

  6 months

Study Arms (1)

Femoral neck fractures

Patients admitted to Sundsvall hospital for a displaced femoral neck fracture and treated with a hip arthroplasty

Procedure: Hip arthroplasty

Interventions

Hip arthroplasty PROCEDURE

Treatment with a hip arthroplasty (semi- or total hip arthroplasty) for a displaced femoral neck fracture

Femoral neck fractures

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients treated with a hip arthroplasty for a displaced femoral neck fracture at Sundsvall hospital, Sweden between 2006 and 2015. All patients were included.

You may qualify if:

• Displaced femoral neck fracture
• Treated with a primary hip arthroplasty

Sponsors & Collaborators

• Sundsvall Hospital: lead

Related Publications (5)

• Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR; Infectious Diseases Society of America. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013 Jan;56(1):1-10. doi: 10.1093/cid/cis966.

  PMID: 23230301 BACKGROUND

• Dale H, Fenstad AM, Hallan G, Havelin LI, Furnes O, Overgaard S, Pedersen AB, Karrholm J, Garellick G, Pulkkinen P, Eskelinen A, Makela K, Engesaeter LB. Increasing risk of prosthetic joint infection after total hip arthroplasty. Acta Orthop. 2012 Oct;83(5):449-58. doi: 10.3109/17453674.2012.733918.

  PMID: 23083433 BACKGROUND

• Edwards C, Counsell A, Boulton C, Moran CG. Early infection after hip fracture surgery: risk factors, costs and outcome. J Bone Joint Surg Br. 2008 Jun;90(6):770-7. doi: 10.1302/0301-620X.90B6.20194.

  PMID: 18539671 BACKGROUND

• Fisman DN, Reilly DT, Karchmer AW, Goldie SJ. Clinical effectiveness and cost-effectiveness of 2 management strategies for infected total hip arthroplasty in the elderly. Clin Infect Dis. 2001 Feb 1;32(3):419-30. doi: 10.1086/318502. Epub 2001 Jan 26.

  PMID: 11170950 BACKGROUND

• Noailles T, Brulefert K, Chalopin A, Longis PM, Gouin F. What are the risk factors for post-operative infection after hip hemiarthroplasty? Systematic review of literature. Int Orthop. 2016 Sep;40(9):1843-8. doi: 10.1007/s00264-015-3033-y. Epub 2015 Nov 27.

  PMID: 26611729 BACKGROUND

MeSH Terms

Conditions

Femoral Neck Fractures; Infections

Interventions

Arthroplasty, Replacement, Hip

Condition Hierarchy (Ancestors)

Hip Fractures; Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries

Intervention Hierarchy (Ancestors)

Arthroplasty, Replacement; Arthroplasty; Orthopedic Procedures; Surgical Procedures, Operative; Plastic Surgery Procedures; Prosthesis Implantation

Study Officials

• Sebastian Mukka, M.D, Ph.D

  Umeå University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 8, 2016
• First Posted: May 13, 2016
• Study Start: January 1, 2016
• Primary Completion: May 1, 2016
• Study Completion: May 1, 2016
• Last Updated: May 13, 2016

Record last verified: 2016-05