Postoperative Outcomes After Positive Intraoperative Messages

NCT02765750 | Terminated

• 1 other identifier: 4659
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

The patients scheduled for laparoscopic cholecystectomy will be allocated to 3 groups. Group A and B patients will listen to a positive message under general anesthesia. Group C patients will not listen to the message. The postoperative pain, analgesic consumption and frequency of nausea, vomiting and emergence agitation episodes will be documented and compared between the 3 groups.

Conditions

Postoperative Pain; Postoperative Nausea; Postoperative Vomiting

Keywords

Emergence agitation

Outcome Measures

Primary Outcomes (10)

• Pain Intensity.

  The patients will be asked to evaluate their postoperative pain by using the 11grade Numerical Rating Scale (0 no pain, 10 maximum possible pain). Pain will be evaluated in supine position, after cough and after change of position from supine to standing.

  Within an average of 15 minutes after emergence from general anesthesia.

• Postoperative paracetamol consumption.

  The patients will be instructed to ask for analgesics as needed. When rescue analgesia is required 1000mg paracetamol will be administered. The frequency of paracetamol administration will be documented.

  24 hours after emergence from general anesthesia.

• Postoperative tramadol consumption.

  If the administration of paracetamol doesn't relieve postoperative pain and the patients continues to ask for analgesia, 100mg tramadol will be administered. The frequency of tramadol administration will be documented.

  24 hours after emergence from general anesthesia.

• Emergence agitation (yes/no).

  The patients' mental status will be evaluated with the 7grade Riker's Agitation-Sedation Scale. If the patient has a score of 5 or greater he will be documented as a case of emergence agitation.

  Within an average of 10 minutes after emergence from general anesthesia.

• Postoperative nausea.

  The frequency of episodes of nausea will be documented.

  24 hours after emergence from general anesthesia.

• Postoperative vomiting.

  The frequency of episodes of vomiting will be documented.

  24 hours after emergence from general anesthesia.

• Pain Intensity.

  The patients will be asked to evaluate their postoperative pain by using the 11 grade Numerical Rating Scale (0 no pain, 10 maximum possible pain). Pain will be evaluated in supine position, after cough and after change of position from supine to standing.

  1 hour after the end of surgery.

• Pain Intensity.

  Numerical Rating Scale (0 no pain, 10 maximum possible pain). Pain will be evaluated in supine position, after cough and after change of position from supine to standing.

  6 hours after the end of surgery.

• Pain Intensity.

  Numerical Rating Scale (0 no pain, 10 maximum possible pain). Pain will be evaluated in supine position, after cough and after change of position from supine to standing.

  12 hours after the end of surgery.

• Pain Intensity.

  Numerical Rating Scale (0 no pain, 10 maximum possible pain). Pain will be evaluated in supine position, after cough and after change of position from supine to standing.

  24 hours after the end of surgery.

Secondary Outcomes (1)

• Explicit memory.

  24 hours after emergence from general anesthesia.

Study Arms (3)

BIS 40-60

EXPERIMENTAL

Patient with intraoperative Bispectral Index (BIS) 40-60.

Behavioral: Intraoperative positive messages

BIS 20-40

EXPERIMENTAL

Patient with intraoperative Bispectral Index (BIS) 20-40.

Behavioral: Intraoperative positive messages

Placebo

PLACEBO COMPARATOR

Placebo group

Behavioral: No message

Interventions

Intraoperative positive messages BEHAVIORAL

The message "You are in the operating room. Everything is going very well. When you wake up you will be very calm, you will not feel pain and you will not have nausea" will be played in greek language by headphones to the patient when the Bispectral Index (BIS) is 40-60.

BIS 40-60

No message BEHAVIORAL

The headphones will be placed on patient's ears but no message will be played.

Placebo

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Laparoscopic cholecystectomy.
• ASA 1-3

You may not qualify if:

• Hearing loss.
• Chronic use of drugs which affect the central nervous system (antidepressants, antiepileptics, opioids, benzodiazepines)

Sponsors & Collaborators

• 424 General Military Hospital: lead

Study Sites (1)

424 Army General Hospital Department of Anesthesia

Thessaloniki, 56429, Greece

Location

Related Publications (82)

• Abdeshahi SK, Hashemipour MA, Mesgarzadeh V, Shahidi Payam A, Halaj Monfared A. Effect of hypnosis on induction of local anaesthesia, pain perception, control of haemorrhage and anxiety during extraction of third molars: a case-control study. J Craniomaxillofac Surg. 2013 Jun;41(4):310-5. doi: 10.1016/j.jcms.2012.10.009. Epub 2012 Dec 14.

  PMID: 23253486 BACKGROUND

• Aberg KC, Albrecht E, Tartaglia EM, Farron A, Soom P, Herzog MH. Anesthesia prevents auditory perceptual learning. Anesthesiology. 2009 Nov;111(5):1010-5. doi: 10.1097/01.anes.0000363310.19041.90.

  PMID: 19858871 BACKGROUND

• Aceto P, Valente A, Gorgoglione M, Adducci E, De Cosmo G. Relationship between awareness and middle latency auditory evoked responses during surgical anaesthesia. Br J Anaesth. 2003 May;90(5):630-5. doi: 10.1093/bja/aeg113.

  PMID: 12697591 BACKGROUND

• Aceto P, Lai C, Perilli V, Dello Russo C, Federico B, Navarra P, Proietti R, Sollazzi L. Stress-related biomarkers of dream recall and implicit memory under anaesthesia. Anaesthesia. 2013 Nov;68(11):1141-7. doi: 10.1111/anae.12386. Epub 2013 Aug 19.

  PMID: 23952901 BACKGROUND

• Andrade J. Does memory priming during anesthesia matter? Anesthesiology. 2005 Nov;103(5):919-20. doi: 10.1097/00000542-200511000-00002. No abstract available.

  PMID: 16249662 BACKGROUND

• Andrade J. Investigations of hypesthesia: using anesthetics to explore relationships between consciousness, learning, and memory. Conscious Cogn. 1996 Dec;5(4):562-80. doi: 10.1006/ccog.1996.0033.

  PMID: 9063616 BACKGROUND

• Andrade J. Learning during anaesthesia: a review. Br J Psychol. 1995 Nov;86 ( Pt 4):479-506. doi: 10.1111/j.2044-8295.1995.tb02566.x.

  PMID: 8542198 BACKGROUND

• Andrade J, Deeprose C. Unconscious memory formation during anaesthesia. Best Pract Res Clin Anaesthesiol. 2007 Sep;21(3):385-401. doi: 10.1016/j.bpa.2007.04.006.

  PMID: 17900016 BACKGROUND

• American Society of Anesthesiologists Task Force on Intraoperative Awareness. Practice advisory for intraoperative awareness and brain function monitoring: a report by the american society of anesthesiologists task force on intraoperative awareness. Anesthesiology. 2006 Apr;104(4):847-64. doi: 10.1097/00000542-200604000-00031. No abstract available.

  PMID: 16571982 BACKGROUND

• Bailey AR, Jones JG. Patients' memories of events during general anaesthesia. Anaesthesia. 1997 May;52(5):460-76. doi: 10.1111/j.1365-2044.1997.133-az0134.x.

  PMID: 9165967 BACKGROUND

• Barr G, Anderson RE, Owall A, Jakobsson JG. Being awake intermittently during propofol-induced hypnosis: a study of BIS, explicit and implicit memory. Acta Anaesthesiol Scand. 2001 Aug;45(7):834-8. doi: 10.1034/j.1399-6576.2001.045007834.x.

  PMID: 11472283 BACKGROUND

• Bejjani G, Lequeux PY, Schmartz D, Engelman E, Barvais L. No evidence of memory processing during propofol-remifentanil target-controlled infusion anesthesia with bispectral index monitoring in cardiac surgery. J Cardiothorac Vasc Anesth. 2009 Apr;23(2):175-81. doi: 10.1053/j.jvca.2008.09.016. Epub 2008 Nov 20.

  PMID: 19026570 BACKGROUND

• Bennett HL, Davis HS, Giannini JA. Non-verbal response to intraoperative conversation. Br J Anaesth. 1985 Feb;57(2):174-9. doi: 10.1093/bja/57.2.174.

  PMID: 3970796 BACKGROUND

• Block RI, Ghoneim MM, Sum Ping ST, Ali MA. Efficacy of therapeutic suggestions for improved postoperative recovery presented during general anesthesia. Anesthesiology. 1991 Nov;75(5):746-55. doi: 10.1097/00000542-199111000-00005.

  PMID: 1952199 BACKGROUND

• Block RI, Ghoneim MM, Sum Ping ST, Ali MA. Human learning during general anaesthesia and surgery. Br J Anaesth. 1991 Feb;66(2):170-8. doi: 10.1093/bja/66.2.170.

  PMID: 1817616 BACKGROUND

• Block RI, Ghoneim MM. Insensitivity of implicit memory to anesthesia methods. Anesthesiology. 1994 Aug;81(2):516-7. doi: 10.1097/00000542-199408000-00036. No abstract available.

  PMID: 8053605 BACKGROUND

• Boeke S, Bonke B, Bouwhuis-Hoogerwerf ML, Bovill JG, Zwaveling A. Effects of sounds presented during general anaesthesia on postoperative course. Br J Anaesth. 1988 May;60(6):697-702. doi: 10.1093/bja/60.6.697.

  PMID: 3377953 BACKGROUND

• Bonebakker AE, Bonke B, Klein J, Wolters G, Stijnen T, Passchier J, Merikle PM. Information processing during general anesthesia: evidence for unconscious memory. Mem Cognit. 1996 Nov;24(6):766-76. doi: 10.3758/bf03201101.

  PMID: 8961821 BACKGROUND

• Bonebakker AE, Jelicic M, Passchier J, Bonke B. Memory during general anesthesia: practical and methodological aspects. Conscious Cogn. 1996 Dec;5(4):542-61. doi: 10.1006/ccog.1996.0032.

  PMID: 9063615 BACKGROUND

• Bonett E, Pham X, Smith KR, Howard K, Sheppard S, Davidson A. Implicit memory formation using the word stem completion task during anesthesia in children. Paediatr Anaesth. 2014 Mar;24(3):290-6. doi: 10.1111/pan.12299. Epub 2013 Nov 13.

  PMID: 24219512 BACKGROUND

• Del Casale A, Ferracuti S, Rapinesi C, Serata D, Caltagirone SS, Savoja V, Piacentino D, Callovini G, Manfredi G, Sani G, Kotzalidis GD, Girardi P. Pain perception and hypnosis: findings from recent functional neuroimaging studies. Int J Clin Exp Hypn. 2015;63(2):144-70. doi: 10.1080/00207144.2015.1002371.

  PMID: 25719519 BACKGROUND

• Cascella M. What about Memory, Consciousness, Recall, and Awareness in Anesthesia? Iran J Med Sci. 2014 May;39(3):311-2. No abstract available.

  PMID: 24850992 BACKGROUND

• Cheng CM, Huang CL. Processes of conscious and unconscious memory: evidence from current research on dissociation of memories within a test. Am J Psychol. 2011 Winter;124(4):421-40. doi: 10.5406/amerjpsyc.124.4.0421.

  PMID: 22324282 BACKGROUND

• Dawson P, Van Hamel C, Wilkinson D, Warwick P, O'Connor M. Patient-controlled analgesia and intra-operative suggestion. Anaesthesia. 2001 Jan;56(1):65-9. doi: 10.1046/j.1365-2044.2001.01763-5.x.

  PMID: 11167439 BACKGROUND

• Deeprose C, Andrade J, Harrison D, Edwards N. Unconscious auditory priming during surgery with propofol and nitrous oxide anaesthesia: a replication. Br J Anaesth. 2005 Jan;94(1):57-62. doi: 10.1093/bja/aeh289. Epub 2004 Oct 14.

  PMID: 15486010 BACKGROUND

• Deeprose C, Andrade J, Varma S, Edwards N. Unconscious learning during surgery with propofol anaesthesia. Br J Anaesth. 2004 Feb;92(2):171-7. doi: 10.1093/bja/aeh054.

  PMID: 14722165 BACKGROUND

• Deeprose C, Andrade J. Is priming during anesthesia unconscious? Conscious Cogn. 2006 Mar;15(1):1-23. doi: 10.1016/j.concog.2005.05.003. Epub 2005 Jul 25.

  PMID: 16043367 BACKGROUND

• Dobrunz UE, Jaeger K, Vetter G. Memory priming during light anaesthesia with desflurane and remifentanil anaesthesia. Br J Anaesth. 2007 Apr;98(4):491-6. doi: 10.1093/bja/aem008. Epub 2007 Feb 27.

  PMID: 17327251 BACKGROUND

• Evans C, Richardson PH. Improved recovery and reduced postoperative stay after therapeutic suggestions during general anaesthesia. Lancet. 1988 Aug 27;2(8609):491-3. doi: 10.1016/s0140-6736(88)90131-6.

  PMID: 2900410 BACKGROUND

• Flouda L, Pandazi A, Papageorgiou C, Perrea D, Krepi E, Kostopanagiotou G. Comparative effects of sevoflurane and propofol based general anaesthesia for elective surgery on memory. Arch Med Sci. 2013 Feb 21;9(1):105-11. doi: 10.5114/aoms.2013.33351.

  PMID: 23515343 BACKGROUND

• Fowler SL, Rasinski HM, Geers AL, Helfer SG, France CR. Concept priming and pain: an experimental approach to understanding gender roles in sex-related pain differences. J Behav Med. 2011 Apr;34(2):139-47. doi: 10.1007/s10865-010-9291-7. Epub 2010 Sep 28.

  PMID: 20878354 BACKGROUND

• Ghoneim MM, Block RI, Dhanaraj VJ, Todd MM, Choi WW, Brown CK. Auditory evoked responses and learning and awareness during general anesthesia. Acta Anaesthesiol Scand. 2000 Feb;44(2):133-43. doi: 10.1034/j.1399-6576.2000.440202.x.

  PMID: 10695905 BACKGROUND

• Ghoneim MM. Drugs and human memory (part 1): Clinical, theoretical, and methodologic issues. Anesthesiology. 2004 Apr;100(4):987-1002. doi: 10.1097/00000542-200404000-00033. No abstract available.

  PMID: 15087638 BACKGROUND

• Ghoneim MM, Block RI. Learning and memory during general anesthesia: an update. Anesthesiology. 1997 Aug;87(2):387-410. doi: 10.1097/00000542-199708000-00027. No abstract available.

  PMID: 9286904 BACKGROUND

• Goldmann L, Shah MV, Hebden MW. Memory of cardiac anaesthesia. Psychological sequelae in cardiac patients of intra-operative suggestion and operating room conversation. Anaesthesia. 1987 Jun;42(6):596-603. doi: 10.1111/j.1365-2044.1987.tb03082.x.

  PMID: 3618993 BACKGROUND

• Hadzidiakos D, Horn N, Degener R, Buchner A, Rehberg B. Analysis of Memory Formation during General Anesthesia (Propofol/Remifentanil) for Elective Surgery Using the Process-dissociation Procedure. Anesthesiology. 2009 Aug;111(2):293-301. doi: 10.1097/ALN.0b013e3181ac4a4b.

  PMID: 19568158 BACKGROUND

• Hughes JA, Sanders LD, Dunne JA, Tarpey J, Vickers MD. Reducing smoking. The effect of suggestion during general anaesthesia on postoperative smoking habits. Anaesthesia. 1994 Feb;49(2):126-8. doi: 10.1111/j.1365-2044.1994.tb03368.x.

  PMID: 7864913 BACKGROUND

• Iselin-Chaves IA, Willems SJ, Jermann FC, Forster A, Adam SR, Van der Linden M. Investigation of implicit memory during isoflurane anesthesia for elective surgery using the process dissociation procedure. Anesthesiology. 2005 Nov;103(5):925-33. doi: 10.1097/00000542-200511000-00005.

  PMID: 16249665 BACKGROUND

• Jelicic M, Bonke B. Implicit memory for stimuli presented during anaesthesia: role of anaesthetic cocktail and memory test. Med Hypotheses. 1993 Oct;41(4):353-4. doi: 10.1016/0306-9877(93)90082-2.

  PMID: 8289702 BACKGROUND

• Jelicic M, Bonke B, Millar K. Effect of different therapeutic suggestions presented during anaesthesia on post-operative course. Eur J Anaesthesiol. 1993 Sep;10(5):343-7.

  PMID: 11767423 BACKGROUND

• Kekecs Z, Nagy T, Varga K. The effectiveness of suggestive techniques in reducing postoperative side effects: a meta-analysis of randomized controlled trials. Anesth Analg. 2014 Dec;119(6):1407-19. doi: 10.1213/ANE.0000000000000466.

  PMID: 25289661 BACKGROUND

• Kendrick C, Sliwinski J, Yu Y, Johnson A, Fisher W, Kekecs Z, Elkins G. Hypnosis for Acute Procedural Pain: A Critical Review. Int J Clin Exp Hypn. 2016;64(1):75-115. doi: 10.1080/00207144.2015.1099405.

  PMID: 26599994 BACKGROUND

• Kerssens C, Klein J, van der Woerd A, Bonke B. Auditory information processing during adequate propofol anesthesia monitored by electroencephalogram bispectral index. Anesth Analg. 2001 May;92(5):1210-4. doi: 10.1097/00000539-200105000-00024.

  PMID: 11323348 BACKGROUND

• Kerssens C. Implicit memory phenomena under anesthesia are not spurious. Anesthesiology. 2010 Mar;112(3):764-5; author reply 765-6. doi: 10.1097/ALN.0b013e3181cf3ffc. No abstract available.

  PMID: 20179526 BACKGROUND

• Kerssens C, Lubke GH, Klein J, van der Woerd A, Bonke B. Memory function during propofol and alfentanil anesthesia: predictive value of individual differences. Anesthesiology. 2002 Aug;97(2):382-9. doi: 10.1097/00000542-200208000-00015.

  PMID: 12151928 BACKGROUND

• Kerssens C. Using the process dissociation procedure: the meaning and value of comparable base rates. Anesthesiology. 2007 Jul;107(1):172-3; author reply 174. doi: 10.1097/01.anes.0000268505.82823.f3. No abstract available.

  PMID: 17585238 BACKGROUND

• Kerssens C, Gaither JR, Sebel PS. Preserved memory function during bispectral index-guided anesthesia with sevoflurane for major orthopedic surgery. Anesthesiology. 2009 Sep;111(3):518-24. doi: 10.1097/ALN.0b013e3181b05f0b.

  PMID: 19672180 BACKGROUND

• Kerssens C, Ouchi T, Sebel PS. No evidence of memory function during anesthesia with propofol or isoflurane with close control of hypnotic state. Anesthesiology. 2005 Jan;102(1):57-62. doi: 10.1097/00000542-200501000-00012.

  PMID: 15618787 BACKGROUND

• Kessels RP, Remmerswaal M, Wilson BA. Assessment of nondeclarative learning in severe Alzheimer dementia: the Implicit Memory Test (IMT). Alzheimer Dis Assoc Disord. 2011 Apr-Jun;25(2):179-83. doi: 10.1097/WAD.0b013e318203f3ab.

  PMID: 21192238 BACKGROUND

• Kurata J, Hemmings HC Jr. Memory and awareness in anaesthesia. Br J Anaesth. 2015 Jul;115 Suppl 1(Suppl 1):i1-i3. doi: 10.1093/bja/aev224. No abstract available.

  PMID: 26174293 BACKGROUND

• van der Laan WH, van Leeuwen BL, Sebel PS, Winograd E, Baumann P, Bonke B. Therapeutic suggestion has not effect on postoperative morphine requirements. Anesth Analg. 1996 Jan;82(1):148-52. doi: 10.1097/00000539-199601000-00027.

  PMID: 8712392 BACKGROUND

• Lebovits AH, Twersky R, McEwan B. Intraoperative therapeutic suggestions in day-case surgery: are there benefits for postoperative outcome? Br J Anaesth. 1999 Jun;82(6):861-6. doi: 10.1093/bja/82.6.861.

  PMID: 10562780 BACKGROUND

• Leclerc C, Gerard JL, Bricard H. [Intraoperative memory. A study of its incidence in general anesthesia in 326 patients]. Ann Fr Anesth Reanim. 2001 Aug;20(7):592-9. doi: 10.1016/s0750-7658(01)00446-4. French.

  PMID: 11530746 BACKGROUND

• Lequeux PY, Bejjani G, Sekkat H. Implicit memory during isoflurane anesthesia. Anesthesiology. 2006 Aug;105(2):429; author reply 430. doi: 10.1097/00000542-200608000-00032. No abstract available.

  PMID: 16871083 BACKGROUND

• Lequeux PY, Hecquet F, Bredas P. Does anesthetic regimen influence implicit memory during general anesthesia? Anesth Analg. 2014 Nov;119(5):1174-9. doi: 10.1213/ANE.0000000000000162.

  PMID: 24797121 BACKGROUND

• Liu WH, Standen PJ, Aitkenhead AR. Therapeutic suggestions during general anaesthesia in patients undergoing hysterectomy. Br J Anaesth. 1992 Mar;68(3):277-81. doi: 10.1093/bja/68.3.277.

  PMID: 1547052 BACKGROUND

• Lubke GH, Kerssens C, Phaf H, Sebel PS. Dependence of explicit and implicit memory on hypnotic state in trauma patients. Anesthesiology. 1999 Mar;90(3):670-80. doi: 10.1097/00000542-199903000-00007.

  PMID: 10078666 BACKGROUND

• Lubke GH, Kerssens C, Gershon RY, Sebel PS. Memory formation during general anesthesia for emergency cesarean sections. Anesthesiology. 2000 Apr;92(4):1029-34. doi: 10.1097/00000542-200004000-00020.

  PMID: 10754622 BACKGROUND

• Lubke GH, Sebel PS. Awareness and different forms of memory in trauma anaesthesia. Curr Opin Anaesthesiol. 2000 Apr;13(2):161-5. doi: 10.1097/00001503-200004000-00013.

  PMID: 17016296 BACKGROUND

• Mashour GA, Avidan MS. Intraoperative awareness: controversies and non-controversies. Br J Anaesth. 2015 Jul;115 Suppl 1:i20-i26. doi: 10.1093/bja/aev034. Epub 2015 Mar 3.

  PMID: 25735710 BACKGROUND

• McLintock TT, Aitken H, Downie CF, Kenny GN. Postoperative analgesic requirements in patients exposed to positive intraoperative suggestions. BMJ. 1990 Oct 6;301(6755):788-90. doi: 10.1136/bmj.301.6755.788.

  PMID: 2224266 BACKGROUND

• Millar K. Efficacy of therapeutic suggestions presented during anaesthesia: re-analysis of conflicting results. Br J Anaesth. 1993 Oct;71(4):597-601. doi: 10.1093/bja/71.4.597.

  PMID: 8260315 BACKGROUND

• Munte S, Schmidt M, Meyer M, Nager W, Lullwitz E, Munte TF, Piepenbrock S. Implicit memory for words played during isoflurane- or propofol-based anesthesia: the lexical decision task. Anesthesiology. 2002 Mar;96(3):588-94. doi: 10.1097/00000542-200203000-00013.

  PMID: 11873032 BACKGROUND

• Munte S, Kobbe I, Demertzis A, Lullwitz E, Munte TF, Piepenbrock S, Leuwer M. Increased reading speed for stories presented during general anesthesia. Anesthesiology. 1999 Mar;90(3):662-9. doi: 10.1097/00000542-199903000-00006.

  PMID: 10078665 BACKGROUND

• Munte S, Lullwitz E, Leuwer M, Mitzlaff B, Munte TF, Hussein S, Piepenbrock SA. No implicit memory for stories played during isoflurane/alfentanil/nitrous oxide anesthesia: a reading speed measurement. Anesth Analg. 2000 Mar;90(3):733-8. doi: 10.1097/00000539-200003000-00041.

  PMID: 10702466 BACKGROUND

• Munte S, Munte TF, Mitzlaff B, Walz R, Leuwer M, Piepenbrock S. Postoperative reading speed does not indicate implicit memory in elderly cardiac patients after propofol and remifentanyl anaesthesia. Acta Anaesthesiol Scand. 2001 Jul;45(6):750-5. doi: 10.1034/j.1399-6576.2001.045006750.x.

  PMID: 11421835 BACKGROUND

• Myles PS, Hendrata M, Layher Y, Williams NJ, Hall JL, Moloney JT, Powell J. Double-blind, randomized trial of cessation of smoking after audiotape suggestion during anaesthesia. Br J Anaesth. 1996 May;76(5):694-8. doi: 10.1093/bja/76.5.694.

  PMID: 8688271 BACKGROUND

• Nilsson U, Rawal N, Unestahl LE, Zetterberg C, Unosson M. Improved recovery after music and therapeutic suggestions during general anaesthesia: a double-blind randomised controlled trial. Acta Anaesthesiol Scand. 2001 Aug;45(7):812-7. doi: 10.1034/j.1399-6576.2001.045007812.x.

  PMID: 11472279 BACKGROUND

• Oddby-Muhrbeck E, Jakobsson J, Enquist B. Implicit processing and therapeutic suggestion during balanced anaesthesia. Acta Anaesthesiol Scand. 1995 Apr;39(3):333-7. doi: 10.1111/j.1399-6576.1995.tb04072.x.

  PMID: 7793211 BACKGROUND

• Pham X, Smith KR, Sheppard SJ, Bradshaw C, Lo E, Davidson AJ. Implicit memory formation during routine anesthesia in children: a double-masked randomized controlled trial. Anesthesiology. 2010 May;112(5):1097-104. doi: 10.1097/ALN.0b013e3181d692c2.

  PMID: 20354436 BACKGROUND

• Rauchs G, Desgranges B, Foret J, Eustache F. The relationships between memory systems and sleep stages. J Sleep Res. 2005 Jun;14(2):123-40. doi: 10.1111/j.1365-2869.2005.00450.x.

  PMID: 15910510 BACKGROUND

• Reasor JD, Poe GR. Learning and memory during sleep and anesthesia. Int Anesthesiol Clin. 2008 Summer;46(3):105-29. doi: 10.1097/AIA.0b013e318181e513. No abstract available.

  PMID: 18617820 BACKGROUND

• Renna M, Lang EM, Lockwood GG. The effect of sevoflurane on implicit memory: a double-blind, randomised study. Anaesthesia. 2000 Jul;55(7):634-40. doi: 10.1046/j.1365-2044.2000.01326.x.

  PMID: 10919417 BACKGROUND

• Richter M, Schroeter C, Puensch T, Straube T, Hecht H, Ritter A, Miltner WH, Weiss T. Pain-related and negative semantic priming enhances perceived pain intensity. Pain Res Manag. 2014 Mar-Apr;19(2):69-74. doi: 10.1155/2014/425321.

  PMID: 24716197 BACKGROUND

• Rundshagen I, Schnabel K, Schulte am Esch J. Recovery of memory after general anaesthesia: clinical findings and somatosensory evoked responses. Br J Anaesth. 2002 Mar;88(3):362-8. doi: 10.1093/bja/88.3.362.

  PMID: 11990267 BACKGROUND

• Russell IF, Wang M. Absence of memory for intra-operative information during surgery with total intravenous anaesthesia. Br J Anaesth. 2001 Feb;86(2):196-202. doi: 10.1093/bja/86.2.196.

  PMID: 11573659 BACKGROUND

• Sebel PS. Memory during anesthesia: gone but not forgotten? Anesth Analg. 1995 Oct;81(4):668-70. doi: 10.1097/00000539-199510000-00002. No abstract available.

  PMID: 7573991 BACKGROUND

• Stonell CA, Leslie K, He C, Lee L. No sex differences in memory formation during general anesthesia. Anesthesiology. 2006 Nov;105(5):920-6. doi: 10.1097/00000542-200611000-00012.

  PMID: 17065885 BACKGROUND

• Veselis RA. Gone but not forgotten-or was it? Br J Anaesth. 2004 Feb;92(2):161-3. doi: 10.1093/bja/aeh030. No abstract available.

  PMID: 14722162 BACKGROUND

• Veselis RA. Memory formation during anaesthesia: plausibility of a neurophysiological basis. Br J Anaesth. 2015 Jul;115 Suppl 1(Suppl 1):i13-i19. doi: 10.1093/bja/aev035. Epub 2015 Mar 3.

  PMID: 25735711 BACKGROUND

• Veselis RA. Memory function during anesthesia. Anesthesiology. 1999 Mar;90(3):648-50. doi: 10.1097/00000542-199903000-00003. No abstract available.

  PMID: 10078662 BACKGROUND

• Veselis RA. Memory: a guide for anaesthetists. Best Pract Res Clin Anaesthesiol. 2007 Sep;21(3):297-312. doi: 10.1016/j.bpa.2007.04.002.

  PMID: 17900010 BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative; Postoperative Nausea and Vomiting; Emergence Delirium

Interventions

NMT1 protein, S pombe

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Vomiting; Delirium; Confusion; Neurobehavioral Manifestations; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Georgios Kotsovolis, Dr

  424 Army General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: April 29, 2016
• First Posted: May 9, 2016
• Study Start: March 1, 2016
• Primary Completion: February 1, 2018
• Study Completion: March 1, 2018
• Last Updated: June 28, 2018

Record last verified: 2018-06

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)