Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years

NCT02763605 | Unknown

• 1 other identifier: 201312046RINB
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Acanthamoebic keratitis is an important corneal disease which may cause severe complication. The difficulty in diagnosis, the difficulty in treatment, and the long treatment process are factors leading to the poor prognosis of these patients. In this retrospective study, the investigators try to analyze the tissue proven Acanthamoebic keratitis diagnosed in our hospital. The investigators will focus on the in vivo confocal microscopic results, the medical history and the medical/surgical treatment outcome. The investigators will collect the tissue proven cases according to the data provided by laboratory diagnosis department and pathological department. The in vivo confocal microscopic results will be collected and analyzed. The investigators will also look through the photography of the external eyes from data stored in PAC system. The medical history and treatment outcome will be studied from clinical chart review. From this study, the investigators aimed to find out a easy way of diagnosing Acanthamoebic keratitis from in vivo confocal microscopy, and find out a better way for treatment.

Conditions

Acanthamoeba Keratitis

Keywords

Acanthamoeba Keratitis; in vivo confocal microscopic

Outcome Measures

Primary Outcomes (1)

• Number of participants with typical image finding under an in vivo confocal microscope (Confoscan 3.4.1; Nidek Technologies, Padova, Italy)

  through study completion, an average of about 10 year microscope diagnosis and disease progress prediction of patients with Acanthamoe

Study Arms (1)

patients diagnosed with acanthamoeba keratitis

Inclusion Criteria: \- All patients presenting to National Taiwan University Department from Jun. 1st, 2003 to dec. 30th , 2016 with the tissue proven corneal AK will be included. Exclusion Criteria \- Patients with tissue proven corneal AK during from Jun. 1st, 2003 to dec. 30th , 2016, but without in vivo confocal data, or complete chart records.

Other: no intervention

Interventions

no intervention OTHER

patients diagnosed with acanthamoeba keratitis

Eligibility Criteria

• Age: 10 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The in vivo confocal microscopic data and medical records of all recruited patients diagnosed with Acanthamoeba Keratitis will be reviewed after approved by the NTUH Institutional Review Board Committee. Data collected include patient demographics (age, gender), local findings, external eye photos, treatment course and treatment outcome. In vivo confocal microscope exam results will be compared with the clinical manifestation.

You may qualify if:

• presenting to National Taiwan University Department from Jun. 1st, 2003 to dec. 30th , 2016
• suspecting Acanthamoeba Keratitis by the ophthalmologist
• drug treatment as Acanthamoeba Keratitis successed
• tissue proved to be Acanthamoeba Keratitis
• referred from the other hospital with the diagnose of Acanthamoeba Keratitis

You may not qualify if:

• patients suspect corneal Acanthamoeba Keratitis from Jun. 1st, 2003 to dec. 30th , 2013, but without in vivo confocal data, or complete chart records.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan, 100, Taiwan

RECRUITING

Related Publications (13)

• Naginton J, Watson PG, Playfair TJ, McGill J, Jones BR, Steele AD. Amoebic infection of the eye. Lancet. 1974 Dec 28;2(7896):1537-40. doi: 10.1016/s0140-6736(74)90285-2. No abstract available.

  PMID: 4140981 BACKGROUND

• Mathers WD, Sutphin JE, Folberg R, Meier PA, Wenzel RP, Elgin RG. Outbreak of keratitis presumed to be caused by Acanthamoeba. Am J Ophthalmol. 1996 Feb;121(2):129-42. doi: 10.1016/s0002-9394(14)70577-x.

  PMID: 8623882 BACKGROUND

• Claerhout I, Goegebuer A, Van Den Broecke C, Kestelyn P. Delay in diagnosis and outcome of Acanthamoeba keratitis. Graefes Arch Clin Exp Ophthalmol. 2004 Aug;242(8):648-53. doi: 10.1007/s00417-003-0805-7.

  PMID: 15221303 BACKGROUND

• Winchester K, Mathers WD, Sutphin JE, Daley TE. Diagnosis of Acanthamoeba keratitis in vivo with confocal microscopy. Cornea. 1995 Jan;14(1):10-7.

  PMID: 7712728 BACKGROUND

• Matsumoto Y, Dogru M, Sato EA, Katono Y, Uchino Y, Shimmura S, Tsubota K. The application of in vivo confocal scanning laser microscopy in the management of Acanthamoeba keratitis. Mol Vis. 2007 Jul 25;13:1319-26.

  PMID: 17679934 BACKGROUND

• Parmar DN, Awwad ST, Petroll WM, Bowman RW, McCulley JP, Cavanagh HD. Tandem scanning confocal corneal microscopy in the diagnosis of suspected acanthamoeba keratitis. Ophthalmology. 2006 Apr;113(4):538-47. doi: 10.1016/j.ophtha.2005.12.022.

  PMID: 16581415 BACKGROUND

• Yokogawa H, Kobayashi A, Yamazaki N, Ishibashi Y, Oikawa Y, Tokoro M, Sugiyama K. Bowman's layer encystment in cases of persistent Acanthamoeba keratitis. Clin Ophthalmol. 2012;6:1245-51. doi: 10.2147/OPTH.S34695. Epub 2012 Aug 2.

  PMID: 22927735 BACKGROUND

• Rezaei Kanavi M, Naghshgar N, Javadi MA, Sadat Hashemi M. Various confocal scan features of cysts and trophozoites in cases with Acanthamoeba keratitis. Eur J Ophthalmol. 2012;22 Suppl 7:S46-50. doi: 10.5301/ejo.5000139.

  PMID: 22427148 BACKGROUND

• Pfister DR, Cameron JD, Krachmer JH, Holland EJ. Confocal microscopy findings of Acanthamoeba keratitis. Am J Ophthalmol. 1996 Feb;121(2):119-28. doi: 10.1016/s0002-9394(14)70576-8.

  PMID: 8623881 BACKGROUND

• Shiraishi A, Uno T, Oka N, Hara Y, Yamaguchi M, Ohashi Y. In vivo and in vitro laser confocal microscopy to diagnose acanthamoeba keratitis. Cornea. 2010 Aug;29(8):861-5. doi: 10.1097/ICO.0b013e3181ca36b6.

  PMID: 20508505 BACKGROUND

• Dart JK, Saw VP, Kilvington S. Acanthamoeba keratitis: diagnosis and treatment update 2009. Am J Ophthalmol. 2009 Oct;148(4):487-499.e2. doi: 10.1016/j.ajo.2009.06.009. Epub 2009 Aug 5.

  PMID: 19660733 BACKGROUND

• Radford CF, Lehmann OJ, Dart JK. Acanthamoeba keratitis: multicentre survey in England 1992-6. National Acanthamoeba Keratitis Study Group. Br J Ophthalmol. 1998 Dec;82(12):1387-92. doi: 10.1136/bjo.82.12.1387.

  PMID: 9930269 BACKGROUND

• Oldenburg CE, Acharya NR, Tu EY, Zegans ME, Mannis MJ, Gaynor BD, Whitcher JP, Lietman TM, Keenan JD. Practice patterns and opinions in the treatment of acanthamoeba keratitis. Cornea. 2011 Dec;30(12):1363-8. doi: 10.1097/ICO.0b013e31820f7763.

  PMID: 21993459 BACKGROUND

MeSH Terms

Conditions

Acanthamoeba Keratitis

Condition Hierarchy (Ancestors)

Eye Infections, Parasitic; Parasitic Diseases; Infections; Amebiasis; Protozoan Infections; Keratitis; Corneal Diseases; Eye Diseases; Eye Infections

Study Officials

• Wei-Li Chen, MD,PHD

  professor of National Taiwan University

  STUDY DIRECTOR

Central Study Contacts

Chia-ju Lu, MD

CONTACT

+886223123456; lcjjulie@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 12, 2016
• First Posted: May 5, 2016
• Study Start: January 1, 2014
• Primary Completion: June 1, 2016
• Study Completion: July 1, 2016
• Last Updated: May 9, 2016

Record last verified: 2016-05

Locations

TW (1)