NCT02760147

Brief Summary

The aim of this study is to evaluate the ventilator settings advice given by the BEACON care system in fitting with best level of support in patient under mechanical ventilation in Pressure Support mode.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
85

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2015

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2015

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2015

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

April 28, 2016

Completed
5 days until next milestone

First Posted

Study publicly available on registry

May 3, 2016

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2017

Completed
Last Updated

May 3, 2018

Status Verified

May 1, 2018

Enrollment Period

1 month

First QC Date

April 28, 2016

Last Update Submit

May 2, 2018

Conditions

Keywords

Pressure Support Ventilation

Outcome Measures

Primary Outcomes (1)

  • Reduction of respiratory fatigue of patient under mechanical ventilation

    Esophageal catheter will be positioned and pressure generated by the respiratory muscles will be measured to detect respiratory muscles' fatigue.

    Average of 1 hour

Study Arms (4)

Pressure Support Over Support

OTHER

Pressure Support Level upward by 50%, 2 hours

Device: Pressure Support Over SupportDevice: Pressure Support Under Support

Pressure Support Under Support

OTHER

Pressure Support Level downward by 50%, 2 hours

Device: Pressure Support Over SupportDevice: Pressure Support Under Support

PEEP Over Level

OTHER

PEEP Level upward by 50%, 2 hours

Device: PEEP Over LevelDevice: PEEP Under Level

PEEP Under Level

OTHER

PEEP Level downward by 50%, 2 hours

Device: PEEP Over LevelDevice: PEEP Under Level

Interventions

Pressure Support Level upward by 50%, 2 hours

Pressure Support Over SupportPressure Support Under Support

Pressure Support Level downward by 50%, 2 hours

Pressure Support Over SupportPressure Support Under Support

PEEP Level upward by 50%, 2 hours

PEEP Over LevelPEEP Under Level

PEEP Level downward by 50%, 2 hours

PEEP Over LevelPEEP Under Level

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Under mechanical ventilation in Pressure Support mode

You may not qualify if:

  • Neuromuscular impairment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Azienda Ospedaliero Universitaria Sant'Anna

Ferrara, 44121, Italy

Location

Study Officials

  • Stephen Rees, Medical

    Aalborg University

    STUDY DIRECTOR
  • Dan Stieper Karbing, Engenieer

    Aalborg University

    PRINCIPAL INVESTIGATOR
  • Savino Spadaro, Medicine

    Ferrara University

    PRINCIPAL INVESTIGATOR
  • Carlo Alberto Volta, Medicine

    Ferrara University

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor - Researcher

Study Record Dates

First Submitted

April 28, 2016

First Posted

May 3, 2016

Study Start

July 1, 2015

Primary Completion

August 1, 2015

Study Completion

March 1, 2017

Last Updated

May 3, 2018

Record last verified: 2018-05

Data Sharing

IPD Sharing
Will not share

Locations