NCT02754271

Brief Summary

Exercise training for older hemodialysis patients can greatly improve many of the negative effects and poor health outcomes associated with end-stage kidney disease. Exercise has yet to be incorporated effectively and systematically into routine care. Exercise programs remain rare. When such programs are implemented, their participation rates vary, and they neglect home and community-based activities, as well as the involvement of family caregivers to support and reinforce exercise. This study is intended to address these limitations by introducing a highly accessible and compelling educational film, Fit for Dialysis, designed to introduce, motivate, and sustain exercise for wellness amongst older hemodialysis patients, and exercise counseling and support by family caregivers, nephrologists, and nurses. The objective of this clinical trial is to determine whether and in what ways Fit for Dialysis improves outcomes and influences knowledge/attitudes regarding the importance of exercise-based principles of wellness in the context of end-stage renal disease. Ultimately Fit for Dialysis could be used as a model for dialysis education that supports guideline recommendations that exercise be incorporated into the care and treatment of dialysis patients.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P50-P75 for phase_2

Timeline
Completed

Started Apr 2014

Typical duration for phase_2

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2014

Completed
2.1 years until next milestone

First Submitted

Initial submission to the registry

April 21, 2016

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 28, 2016

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2016

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2017

Completed
Last Updated

April 28, 2016

Status Verified

April 1, 2016

Enrollment Period

2.4 years

First QC Date

April 21, 2016

Last Update Submit

April 25, 2016

Conditions

Outcome Measures

Primary Outcomes (2)

  • Adherence measured by the percentage of time participants achieved at least 70% of prescribed targets of minutes and intensity of exercise per week.

    1-16 weeks

  • Change in functional exercise capacity measured by the 2-Minute Walk Test

    0, 8, 16, 28 weeks

Secondary Outcomes (5)

  • Change in number of steps using a pedometer

    0, 8, 16, 28 weeks

  • Change in basic mobility using the Timed Up and Go

    0, 8, 16, 28 weeks

  • Change in self-assessment of functional of capacities and peak metabolic equivalents using the Duke Activity Status Index

    0, 8, 16, 28 weeks

  • Change in upper extremity strength as a predictor of mortality and deteriorating health using the Grip Strength Test

    0, 8, 16, 28 weeks

  • Change in the frequency of mild, moderate, and strenuous bouts of exercise using the Godin Leisure-Time Exercise Questionnaire

    1-16, 28 weeks

Study Arms (2)

Intervention

EXPERIMENTAL

A research-based film (Fit for Dialysis) and a 16-week exercise program involving activities during dialysis, at home, and in the community.

Other: Fit for Dialysis

Control

NO INTERVENTION

The 16-week exercise program involving activities during dialysis, at home, and in the community.

Interventions

A 15-minute research-based film that explores the barriers and facilitators regarding exercise participation by older hemodialysis patients and support by nephrology staff and family caregivers, and a 16-week exercise program involving activities during dialysis, at home, and in the community.

Intervention

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • Have conversational ability in English
  • Have a medical diagnosis of hemodialysis-dependent end-stage renal disease
  • Are a registered hemodialysis patient in the hospital for at least 3 months
  • Receive ≥ 2 in-centre hemodialysis sessions per week
  • Are ambulatory (with or without aids)
  • Are deemed medically eligible by their nephrologist to participate in an exercise program that includes stretching, strengthening, and cardiovascular components
  • Have a family caregiver who agrees to participate in the exercise program and keep a log of exercises on non-dialysis days

You may not qualify if:

  • Currently participating in regular physical activity (structured exercise that includes a cardiovascular and/or strengthening component ≥ 3 times/week for ≥ 10 min/session

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Humber River Hospital - Wilson Site

Toronto, Ontario, M3M 0B2, Canada

RECRUITING

St. Joseph's Health Centre - Satellite Site

Toronto, Ontario, M8Z 6A4, Canada

ACTIVE NOT RECRUITING

Related Publications (2)

  • Kontos P, Grigorovich A, Colobong R, Miller KL, Nesrallah GE, Binns MA, Alibhai SMH, Parsons T, Jassal SV, Thomas A, Naglie G. Fit for Dialysis: a qualitative exploration of the impact of a research-based film for the promotion of exercise in hemodialysis. BMC Nephrol. 2018 Aug 6;19(1):195. doi: 10.1186/s12882-018-0984-4.

  • Kontos P, Alibhai SM, Miller KL, Brooks D, Colobong R, Parsons T, Jassal SV, Thomas A, Binns M, Naglie G. A prospective 2-site parallel intervention trial of a research-based film to increase exercise amongst older hemodialysis patients. BMC Nephrol. 2017 Jan 26;18(1):37. doi: 10.1186/s12882-017-0454-4.

MeSH Terms

Conditions

Kidney Failure, Chronic

Interventions

Dialysis

Condition Hierarchy (Ancestors)

Renal Insufficiency, ChronicRenal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Chemistry Techniques, AnalyticalInvestigative TechniquesChemical Phenomena

Study Officials

  • Pia Kontos, PhD

    University Health Network, Toronto

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Pia Kontos, PhD

CONTACT

Romeo Colobong, MA

CONTACT

Study Design

Study Type
interventional
Phase
phase 2
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Senior Scientist

Study Record Dates

First Submitted

April 21, 2016

First Posted

April 28, 2016

Study Start

April 1, 2014

Primary Completion

September 1, 2016

Study Completion

March 1, 2017

Last Updated

April 28, 2016

Record last verified: 2016-04

Data Sharing

IPD Sharing
Will not share

Locations