Genetic Basis of Rosacea Study (Control)
Expansion Arm of Papulopustular Rosacea Gene Expression Profiling to Include Normal Individuals as Anatomic Site Specific Controls
1 other identifier
interventional
10
1 country
1
Brief Summary
Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface. It it considered to be a syndrome encompassing various combinations of cutaneous signs including flushing, erythema, telangiectasia, papules, edema, ocular lesions, and rhinophyma. The exact etiology of cutaneous rosacea is unknown but is characterized by persistent vasodilation, increased vascular permeability, and vascular hyper-reactivity of the microcirculation of the central part of the face. The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin. The investigator hopes to better understand the abnormal gene functions that might contribute to this condition. This understanding may lead to the development of additional and better treatments for rosacea.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jan 2016
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 21, 2016
CompletedFirst Submitted
Initial submission to the registry
April 18, 2016
CompletedFirst Posted
Study publicly available on registry
April 25, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2016
CompletedSeptember 26, 2019
September 1, 2019
6 months
April 18, 2016
September 24, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Gene expression profile of papulopustular rosacea compared to normal skin and skin from individuals without rosacea.
Up to 2 years
Study Arms (1)
Control Group
OTHERParticipants who do not have rosacea (control group)
Interventions
Skin biopsies will be performed via the Keys punch technique from normal facial skin.
Eligibility Criteria
You may qualify if:
- Fitzpatrick skin type II or III
- Age greater than or equal to 18 years
- Individuals without a history of rosacea
You may not qualify if:
- Women who are pregnant or lactating
- Use of topical prescription medications or procedures to the face within one month of enrollment
- Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Stanford Dermatology
Redwood City, California, 94603, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Anne Chang
Stanford University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor of Dermatology
Study Record Dates
First Submitted
April 18, 2016
First Posted
April 25, 2016
Study Start
January 21, 2016
Primary Completion
August 1, 2016
Study Completion
August 1, 2016
Last Updated
September 26, 2019
Record last verified: 2019-09
Data Sharing
- IPD Sharing
- Will not share