Measuring the Electrical Properties of Malignant Tissues Ex Vivo

NCT02747212 | Unknown DMC

• 1 other identifier: SXXin-EPs-measurement-ex vivo
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. While the EP informations of cancer tissues are not sufficient enough. The purpose of this study is to measure the electrical properties of the excised malignant tissues obtained from cancer surgeries.

Conditions

Neoplasms

Keywords

electrical properties; malignant tissues; ex vivo

Outcome Measures

Primary Outcomes (2)

• Conductivity of Malignant Tissues Measured Ex Vivo

  one year

• Relative Permittivity of Malignant Tissues Measured Ex Vivo

  one year

Interventions

network analyzer DEVICE

The dielectric properties of the tissues were measured using the open-ended coaxial line method. The measurement system consisted of a network analyzer (Model 4395A, Agilent Corp., Santa Clara, CA) associated with an S-parameter test set (Model 87511A, Agilent Corp., Santa Clara, CA). A semi-rigid coaxial line with a diameter of 3.58 mm was connected to the network analyzer system by using a Bayonet Neill-Concelman connector. The other tip of the coaxial line (probe) was placed on the flat bare surface of the tissue that placed on a measurements experiment platform.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patients who are diagnosed with cancer disease and about to have an operation to excise the cancer tissues

You may qualify if:

• Clinical diagnosis of cancer Disease

You may not qualify if:

• None

Sponsors & Collaborators

• Southern Medical University, China: lead
• Zhujiang Hospital: collaborator

Study Sites (1)

Zhujiang Hospital

Guangzhou, Guangdong, 510280, China

Location

Related Publications (5)

• Athey T W, Stuchly M A and Stuchly S S. Measurement of radio frequency permittivity of biological tissues with an open-ended coaxial line: Part I. Microwave Theory and Techniques, IEEE Transactions on IEEE Trans 30(1): 82-86, 1982.

  BACKGROUND

• Bobowski Jake S, Johnson Thomas. Permittivity measurements of biological samples by an open-ended coaxial line. Progress In Electromagnetics Research B 40: 159-183, 2012.

  BACKGROUND

• Surowiec AJ, Stuchly SS, Barr JB, Swarup A. Dielectric properties of breast carcinoma and the surrounding tissues. IEEE Trans Biomed Eng. 1988 Apr;35(4):257-63. doi: 10.1109/10.1374. No abstract available.

  PMID: 2834285 BACKGROUND

• Smith SR, Foster KR, Wolf GL. Dielectric properties of VX-2 carcinoma versus normal liver tissue. IEEE Trans Biomed Eng. 1986 May;33(5):522-4. doi: 10.1109/TBME.1986.325740. No abstract available.

  PMID: 3710509 BACKGROUND

• Mehta P, Chand K, Narayanswamy D, Beetner D G, Zoughi R and Stoecker W V. Microwave reflectometry as a novel diagnostic tool for detection of skin cancers IEEE Trans. Instrum. Meas. 55: 1309-16, 2006

  BACKGROUND

Related Links

• An Internet resource for the calculation of the dielectric properties of body tissues in the frequency range 10 Hz - 100 GHz Based on data published by C.Gabriel et al. in 1996.

MeSH Terms

Conditions

Neoplasms

Study Officials

• Sherman X Xin, professor

  School of Biomedical Engineering,Southern Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sherman X Xin, professor

CONTACT

008613602733465; xxg@smu.edu.cn

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 22, 2016
• First Posted: April 21, 2016
• Study Start: December 1, 2018
• Primary Completion: August 1, 2019
• Study Completion: January 1, 2020
• Last Updated: October 12, 2018

Record last verified: 2018-10

Locations

CN (1)