Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity

NCT02745613 | Completed DMC

• 1 other identifier: 755513-1
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates whether: (i) a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity. (ii) being prediabetic affects exercise induced improvements in glycemic control. (iii) sex differences affect exercise induced improvements in glycemic control.

Conditions

Insulin Sensitivity/Resistance

Outcome Measures

Primary Outcomes (4)

• Insulin sensitivity

  Insulin sensitivity will be measured hyperinsulinemic -euglycemic clamp

  8-weeks

• Glycemic control (long term)

  Glycated hemoglobin (HbA1c) will be measured from whole blood with a bench top chemistry analyzer

  8-weeks

• Glycemic control (postprandial)

  Postprandial glycemic control will be measured by an oral glucose tolerance test (OGTT)

  8-weeks

• Glycemic variability

  Glycemic variability will be assessed with glucose monitoring

  8-weeks

Secondary Outcomes (4)

• Cellular mitochondria function

  8-weeks

• Cytokines

  8-weeks

• Blood gene expression markers of glycemic control

  8-weeks

• Peripheral blood mononuclear cell (PBMC) markers of glucose metabolism

  8-weeks

Study Arms (2)

Family history of T2D

EXPERIMENTAL

The participants will undergo 8 weeks of combined exercise

Other: 8 weeks of combined exercise intervention

No Family history of T2D

EXPERIMENTAL

The participants will undergo 8 weeks of combined exercise

Other: 8 weeks of combined exercise intervention

Interventions

8 weeks of combined exercise intervention OTHER

The subjects will undergo an 8 week combined exercise intervention

Family history of T2D; No Family history of T2D

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Sedentary/moderately active lifestyle
• Less than 150 minutes/wk. of structured exercise
• Physical activity level ≤ 1.4

You may not qualify if:

• Evidence of significant cardiovascular disease
• Screening blood pressure \>140/90
• Pregnancy or breastfeeding
• Use of drugs affecting energy metabolism or body weight
• Excess alcohol, drug abuse, and smoking
• Eating disorder or eating attitudes interfering with study
• Excessively or active individuals
• Unwillingness to abide by randomization
• Injury that prevents the performance of exercise

Sponsors & Collaborators

• University of Texas, El Paso: lead

Study Sites (1)

University of Texas at El Paso

El Paso, Texas, 79968, United States

Location

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Sudip Bajpeyi, PhD.

  University of Texas, El Paso

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 18, 2016
• First Posted: April 20, 2016
• Study Start: April 1, 2016
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: July 7, 2026

Record last verified: 2026-07

Locations

US (1)