Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?

NCT02733549 | Completed

• 1 other identifier: ADYU-4
• Study Type: observational
• Target: 198
• Locations: 1 country
• Sites: 1

Brief Summary

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of liver function tests for patients with SOD in the ED, and a cost analysis of liver function tests.

Conditions

Dizziness

Outcome Measures

Primary Outcomes (1)

• LFTs serum levels by biochemical method ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and Platelet count (PC)

  The serum levels of LFTs will obtained by the laboratory analysis of blood samples of each participant.

  5 months

Secondary Outcomes (1)

• The cost calculation for the LFTs

  5 months

Study Arms (2)

patient

Patients with sudden onset dizziness (SOD) analysed LFTs

Other: LFTs

control

The control group with 98 healthy volunteer analysed LFTs

Other: LFTs

Interventions

LFTs OTHER

A single 5-ml peripheral venous blood sample was collected from each participant. Serum ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, and albumin level, Platelet count, INR and aPTT were analyzed.

Also known as: liver function tests

control; patient

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Adult patients with sudden onset dizziness admitted to emergency department.

You may qualify if:

• \. Adult patients who were experiencing sudden onset dizziness of unknown etiology for the first time were included in the study

You may not qualify if:

• Patients with a history of chronic diseases such as any liver disease,diabetes mellitus, hypertension,congestive heart failure, hepatitis B or C infection
• Patients with any central dizziness attacks
• Patients with hemodynamically unstable and emesis;
• Patients receiving drugs that could affect liver function tests, such as, acetaminophen, antibiotics, oral contraceptives, antihypertensive drugs (e.g., angiotensinconverting enzyme inhibitors), or hormones (e.g.,estrogen)
• Patients who was experienced dizziness with systemic diseases
• Patients with any neurological disorders
• Patient who do not want to participate in the study

Sponsors & Collaborators

• Adiyaman University Research Hospital: lead

Study Sites (1)

Adiyaman University Research Hospital

Adıyaman, Central, 02000, Turkey (Türkiye)

Location

Related Publications (2)

• Giannini EG, Testa R, Savarino V. Liver enzyme alteration: a guide for clinicians. CMAJ. 2005 Feb 1;172(3):367-79. doi: 10.1503/cmaj.1040752.

  PMID: 15684121 BACKGROUND

• Newman-Toker DE, Hsieh YH, Camargo CA Jr, Pelletier AJ, Butchy GT, Edlow JA. Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. Mayo Clin Proc. 2008 Jul;83(7):765-75. doi: 10.4065/83.7.765.

  PMID: 18613993 BACKGROUND

MeSH Terms

Conditions

Dizziness

Condition Hierarchy (Ancestors)

Sensation Disorders; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Umut Gulacti

  Adiyaman University Medical Faculty

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: March 27, 2016
• First Posted: April 11, 2016
• Study Start: September 1, 2012
• Primary Completion: March 1, 2013
• Study Completion: March 1, 2013
• Last Updated: April 12, 2016

Record last verified: 2016-04

Locations

TU (1)