Histones and Free-plasma DNA After Cardiac Arrest

NCT02733146 | Completed

• 1 other identifier: AU170878
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

Conditions

Heart Arrest; Hypothermia; Post Cardiac Arrest Syndrome

Outcome Measures

Primary Outcomes (2)

• Plasma histones

  The level of plasma histones

  Approximate 24 hours after cardiac arrest

• Free-plasma DNA

  The level of total free-plasma DNA

  Approximate 24 hours after cardiac arrest

Secondary Outcomes (2)

• Plasma histones

  Approximate 48 hours and 72 hours after cardiac arrest

• Free-plasma DNA

  Approximate 48 hours and 72 hours after cardiac arrest

Other Outcomes (2)

• Simplified Acute Physiology Score (SAPS) score

  Approximate 24 hours, 48 hours and 72 hours after cardiac arrest

• Platelet count

  Approximate 24 hours, 48 hours and 72 hours after cardiac arrest

Study Arms (1)

cardiac arrest patients

Patients who has suffered a cardiac arrest

Other: cardiac arrest

Interventions

cardiac arrest OTHER

cardiac arrest patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Cardiac arrest patients with a presumed cardiac origin, treated with targeted temperature management for 24 hours. For comparison; 20 healthy individuals were used.

You may qualify if:

• Out of hospital cardiac arrest of presumed cardiac cause
• Return of spontaneous circulation (ROSC)
• Glasgow Coma Score \< 8
• Age \> 18 years and \< 80 years

You may not qualify if:

• \>60 minutes from the circulatory collapse to ROSC
• Time interval \> 4 hours from cardiac arrest to initiation of targeted temperature management
• Terminal illness
• Coagulation disorder
• Unwitnessed asystolia
• Cerebral performance category 3-4 before the cardiac arrest
• Severe persistent cardiogenic shock
• Pregnancy
• Persistent cardiogenic shock (systolic blood pressure \< 80 despite inotropic treatment)
• New apoplexy or intracerebral hemorrhage
• Lack of consent from the relatives
• Lack of consent from the general practitioner
• Lack of consent from the patient if he/she wakes up and is relevant

Sponsors & Collaborators

• University of Aarhus: lead

Study Sites (1)

Dept of Anesthesiology and Intensive Care and Dept of Clinical Biochemistry, Aarhus University Hospital

Aarhus, Aarhus N, 8200, Denmark

Location

MeSH Terms

Conditions

Heart Arrest; Hypothermia; Post-Cardiac Arrest Syndrome

Interventions

Heart Arrest, Induced

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Body Temperature Changes; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Reperfusion Injury; Vascular Diseases; Postoperative Complications; Pathologic Processes

Intervention Hierarchy (Ancestors)

Cardiac Surgical Procedures; Cardiovascular Surgical Procedures; Surgical Procedures, Operative; Thoracic Surgical Procedures

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 30, 2016
• First Posted: April 11, 2016
• Study Start: October 1, 2015
• Primary Completion: June 1, 2016
• Study Completion: September 1, 2016
• Last Updated: June 2, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)