Tissue Perfusion Indices as Predictor of Outcome in Poly Trauma Patients
Central Venous-arterial Carbon Dioxide Pressure Difference in Correlation to Dynamic Changes of Serum Lactate as an Indicator of Tissue Perfusion in Polytruama Patients
1 other identifier
interventional
40
1 country
1
Brief Summary
Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial and venous CO2, oxygen tension or content as indicators for tissue perfusion.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 23, 2016
CompletedFirst Posted
Study publicly available on registry
April 5, 2016
CompletedStudy Start
First participant enrolled
May 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2018
CompletedSeptember 20, 2016
April 1, 2016
1.3 years
March 23, 2016
September 17, 2016
Conditions
Outcome Measures
Primary Outcomes (3)
the difference between partial pressure of oxygen in arterial and venous blood
6 hours
the difference between partial pressure of carbon dioxide in arterial and venous blood
6 hours
serum level of lactate and its changes
as an index for tissue oxygenation
6 hours
Secondary Outcomes (3)
Kidney function
72 hours
hemodynamic stability including pulse rate and mean arterial blood pressure
72 hours
duration of stay in the critical care unit
72 hours
Study Arms (1)
optimal resuscitation
OTHERThis group of multiple trauma patients will be resuscitated with crystalloids, analgesics, blood products as needed. Then follow up of the difference between arterial and venous CO2 to difference between arterial and venous oxygen tension, serum lactate, renal function, other organ affection along over the short hospital stay period
Interventions
optimal resuscitation to achieve mean arterial blood pressure above 65 mmHG , Central venous pressure more than 8 mmHg , urine out put more than 0.5 ml /Kg/hour
Eligibility Criteria
You may qualify if:
- multiple trauma patients Adult patients
You may not qualify if:
- cardiac renal chronic chest disease diabetic more than 3 years
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Emad Zarief Kamel Said
Asyut, Asyut Governorate, 71111, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Emad Zarief Kamel Said, MD
Assiut University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Lecturer of Anesthesia and critical care Medicine
Study Record Dates
First Submitted
March 23, 2016
First Posted
April 5, 2016
Study Start
May 1, 2016
Primary Completion
September 1, 2017
Study Completion
January 1, 2018
Last Updated
September 20, 2016
Record last verified: 2016-04
Data Sharing
- IPD Sharing
- Will not share