NCT02720861

Brief Summary

To explore the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease in Thai patients.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2015

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2015

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2016

Completed
14 days until next milestone

First Submitted

Initial submission to the registry

March 15, 2016

Completed
13 days until next milestone

First Posted

Study publicly available on registry

March 28, 2016

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2016

Completed
Last Updated

March 28, 2016

Status Verified

March 1, 2016

Enrollment Period

1 year

First QC Date

March 15, 2016

Last Update Submit

March 25, 2016

Conditions

Ischemic Stroke

Keywords

RNF213 rs112735431 GeneAcute Non-embolic ischemic stroke

Outcome Measures

Primary Outcomes (1)

  • Number of Participants With RNF213 rs112735431 Gene polymorphism

    1 year

Study Arms (1)

non embolic ischemic stroke

acute ischemic stroke from atherosclerosis or lacunar stroke

Genetic: DNA sequencing

Interventions

DNA sequencingGENETIC

withdraw 3m blood from vein only once during the whole design to analyse on DNA sequencing on RNF213 rs112735431 Gene

non embolic ischemic stroke

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Acute ischemic stroke patients of Chulalongkorn hospital

You may qualify if:

  • Nationality in Thailand
  • Age equal or more than 18 years
  • Clinical and imaging diagnosis of acute ischemic stroke
  • Patient consent to participate in the research

You may not qualify if:

  • High risk for cardioembolic stroke by TOAST classification
  • Contraindication for venipuncture
  • Pregnancy or breast feeding patient
  • History of head and neck radiation
  • Down's syndrome
  • Marfan syndrome
  • Autoimmune disease such as SLE
  • Ongoing malignancy or remission of malignancy less than 1year

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Suporn Travanichakul

Bangkok, Bangkok, 10330, Thailand

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample.

MeSH Terms

Conditions

Ischemic Stroke

Interventions

Sequence Analysis, DNA

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Sequence AnalysisGenetic TechniquesInvestigative Techniques

Study Officials

  • Suporn Travanichakul, MD

    Chulalongkorn University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Suporn Travanichakul, MD

CONTACT

0858054513stravanichakul@yahoo.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Target Duration
1 Year
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Neurology Division of Chulalongkorn hospital

Study Record Dates

First Submitted

March 15, 2016

First Posted

March 28, 2016

Study Start

March 1, 2015

Primary Completion

March 1, 2016

Study Completion

June 1, 2016

Last Updated

March 28, 2016

Record last verified: 2016-03

Data Sharing

IPD Sharing
Will not share

Not Share

Locations

TH(1)