NCT02712658

Brief Summary

The aim of the study is to investigate the role of K+ and Ca2+ in development of muscle fatigue in trained young men.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2015

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2015

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

October 11, 2015

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2016

Completed
17 days until next milestone

First Posted

Study publicly available on registry

March 18, 2016

Completed
Last Updated

January 31, 2017

Status Verified

January 1, 2017

Enrollment Period

6 months

First QC Date

October 11, 2015

Last Update Submit

January 29, 2017

Conditions

Skeletal Muscle Fatigue in Humans

Outcome Measures

Primary Outcomes (1)

  • Change in time to fatigue during knee-extensor exercise

    1 day

Study Arms (2)

terbutaline

ACTIVE COMPARATOR

terbutaline is administered by injection (0.25-0.5 mg Bricanyl, AstraZeneca diluted in 9 ml isotonic saline)

Drug: Terbutaline

Placebo

PLACEBO COMPARATOR

placebo is administered as isotonic saline (10 ml)

Drug: Placebo

Interventions

TerbutalineDRUG

K+ transport and Ca2+ release and uptake function are stimulated by administration of terbutaline

terbutaline
PlaceboDRUG
Placebo

Eligibility Criteria

Age18 Years - 40 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • physical active healthy men
  • aged 18-40 years

You may not qualify if:

  • smokers
  • allergy towards terbutaline
  • chronic disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Nutrition, Exercise and Sports

Copenhagen, 2100, Denmark

Location

MeSH Terms

Interventions

Terbutaline

Intervention Hierarchy (Ancestors)

EthanolaminesAmino AlcoholsAlcoholsOrganic ChemicalsAmines

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Post.Doc

Study Record Dates

First Submitted

October 11, 2015

First Posted

March 18, 2016

Study Start

September 1, 2015

Primary Completion

March 1, 2016

Study Completion

March 1, 2016

Last Updated

January 31, 2017

Record last verified: 2017-01

Locations

DK(1)