Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane
Consumption of Rocuronium Under Etomidate-based Versus Propofol-based Maintenance of General Anesthesia Under Different Concentration of Sevoflurane- BIS Guided Clinical Trial in a Closed Loop Infusion System
2 other identifiers
interventional
175
0 countries
N/A
Brief Summary
Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2015
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2016
CompletedFirst Submitted
Initial submission to the registry
February 24, 2016
CompletedFirst Posted
Study publicly available on registry
March 17, 2016
CompletedMarch 17, 2016
March 1, 2016
5 months
February 24, 2016
March 16, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
consumption of propofol
Propofol, Etomidate, Rocuronium consumption under specific concentration of sevoflurane keeping BIS between 40-60
Intraoperative
Secondary Outcomes (3)
Recovery Index
Intraoperative
Onset time
Intraoperative
Sevoflurane time
Intraoperative
Study Arms (8)
SP1- sevoflurane MAC 0.5
EXPERIMENTALIn this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60.
SP2- Sevoflurane MAC 0.75
EXPERIMENTALIn this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen.Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60.
SP3 -Sevoflurane MAC 1.0
EXPERIMENTALIn this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 1.0. Propofol infusion is started to keep BIS between 40-60.
SP4- Sevoflurane MAC 0.5
EXPERIMENTALIn this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60.
SP5- Sevoflurane MAC 0.75
EXPERIMENTALIn this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60.
SE1- Sevoflurane MAC 0.5
EXPERIMENTALIn this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.
SE2- Sevoflurane 0.75
EXPERIMENTALIn this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.
SE3- Sevoflurane MAC 1.0
EXPERIMENTALIn this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60.
Interventions
0.5 MAC Sevoflurane
0.75 MAC Sevoflurane
Propofol consumption
Etomidate consumption
Consumption of Rocuronium
Eligibility Criteria
You may qualify if:
- BMI \< 30
- elective Gynaecological/abdominal/urological surgery
- Operation time \< 3hrs
- ASA I/II
- Intubated patients
You may not qualify if:
- Coronary artery disease, cardiac, lung, hepatic and renal insufficiency
- Severe uncontrolled HBP
- Obesity (BMI \>30)
- Neuromuscular and metabolic diseases
- Receiving medication known to influence neuromuscular transmission
- Pregnancy
- Psychiatric disorders
- Allergy history to any of the drugs that will be used
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Guolin Wang, Professor
Head of department anesthesiology
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 24, 2016
First Posted
March 17, 2016
Study Start
July 1, 2015
Primary Completion
December 1, 2015
Study Completion
January 1, 2016
Last Updated
March 17, 2016
Record last verified: 2016-03