Measuring Blood Flow Characteristics Using Dynamic Contrast Enhanced Magnetic Resonance Imaging

NCT02702635 | Completed

• 1 other identifier: 5150234
• Study Type: interventional
• Target: 53
• Locations: 1 country
• Sites: 1

Brief Summary

Dynamic contrast-enhanced (DCE) MRI gives quantitative and semi-quantitative information about the integrity of the vascular system and can be used to quantify blood-brain barrier (BBB) integrity. The BBB plays a pathophysiological role in diabetes, cognitive disorders such as mild cognitive impairment, Alzheimer's disease, multiple sclerosis, and chronic traumatic encephalopathy. Although dysfunctional, changes in BBB integrity for these conditions are thought to be subtle and close to intact values. Recent studies have shown it is possible measure small changes in the BBB integrity as an early sign of disease using DCE MRI. The objective of this study is to apply an optimized DCE imaging protocol and novel image post-processing to obtain new information about the BBB integrity in aging. These techniques show promise for both improving clinical diagnosis, and elucidated the physiology or various disease processes.

Conditions

Brain Injuries; Cerebrovascular Disorders

Outcome Measures

Primary Outcomes (2)

• Correlation between Ktrans values and Omega3 levels

  2 years

• Correlation between Ktrans values and neurocognitive testing

  2 years

Study Arms (1)

All Subjects

EXPERIMENTAL

All recruited subjects

Procedure: DCE MRI of the brain

Interventions

DCE MRI of the brain PROCEDURE

An MRI of the brain including a DCE sequence

All Subjects

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Any person between the ages of 0-100 years, who is undergoing routine magnetic resonance imaging (MRI) with contrast at LLUMC.
• Any person between the ages of 18-100 years, who agrees to undergo routine magnetic resonance imaging (MRI) with contrast at LLUMC.

You may not qualify if:

• Electronic or metal implant that is not MRI safe, pregnancy or claustrophobia
• Not eligible for contrast agent injection (reduced renal function, GFR \< 30 mL/min)

Sponsors & Collaborators

• Loma Linda University: lead

Study Sites (1)

Loma Linda University Medical Center

Loma Linda, California, 92354, United States

Location

MeSH Terms

Conditions

Brain Injuries; Cerebrovascular Disorders

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Samuel Barnes, PhD

  Loma Linda University Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 3, 2016
• First Posted: March 8, 2016
• Study Start: September 15, 2015
• Primary Completion: May 26, 2021
• Study Completion: May 26, 2021
• Last Updated: July 1, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)