Shoulder Disorders in Patients With Parkinson's Disease

NCT02702232 | Completed DMC

• 2 other identifiers: 20150802RSKH-8302-105-DR-25
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson's disease (PD) is a multisystem neurodegenerative disorder that is increasingly recognized in our ageing population. It is characterized by cardinal clinical features including bradykinesia, tremor, rigidity, and postural instability. For most people with PD, the most serious concern is with the motor system: stiffness, slowness of movement, impaired handwriting and coordination, poor mobility and balance. However, more than half of all people with PD have experienced painful symptoms. Most people experience aching, stiffness, numbness and tingling at some point in the course of the illness. Defazio et al reported that pain may begin at clinical onset of PD or thereafter as a non-motor feature of PD.5 Aching muscles and joints are especially common in PD. Rigidity, lack of spontaneous movement, abnormalities of posture and awkward mechanical stresses all contribute to musculoskeletal pain in PD.

Conditions

Parkinson's Disease; Shoulder Pain

Outcome Measures

Primary Outcomes (2)

• Functional examination for diagnosis

  The patient will received Cyriax's functional examination for shoulder joint to make a clinical diagnosis. It included three arm elevation, three tests for glenohumeral joints, and six resisted tests.

  1 year

• Ultrasound (US) examination for diagnosis

  The patient will accept ultrasonography for shoulder joint for diagnosis

  1 year

Secondary Outcomes (3)

• Range of motion

  1 year

• Pain

  1 year

• Disability

  1 year

Study Arms (2)

Parkinson's disease

Patients with PD will be recruited consecutively from a neurology clinic. A group of sex- and age-matched normal subjects with be recruited from the public. These patients will be evaluated by ultrasonography for shoulder.

Other: Ultrasonography

Normal

Normal controls who will be evaluated by ultrasonography for shoulder

Other: Ultrasonography

Interventions

Ultrasonography OTHER

Ultrasonography is applied for normal subjects and patients with Parkinson's disease

Normal; Parkinson's disease

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with PD will be recruited consecutively from a neurology clinic. A group of sex- and age-matched normal subjects with be recruited from the public.

You may qualify if:

• Patients fulfilled the diagnosis of PD, as described by the United Kingdom Parkinson's Disease Society Brain Bank,
• Aged 50 to 80 years old.

You may not qualify if:

• Fracture or dislocation of the shoulder,
• Previous shoulder joint surgery,
• Severe medical comorbidities,
• Cognitive impairment (Mini-Mental Status Examination \< 24).

Sponsors & Collaborators

• Shin Kong Wu Ho-Su Memorial Hospital: lead

Study Sites (1)

Shin Kong Wu Ho-Su Memorial Hospital

Taipei, Taiwan

Location

Related Publications (1)

• Hsieh LF, Kuo YC, Lin YT, Liu YF, Wang HC. Ultrasonographic imaging findings of the shoulder in patients with Parkinson disease. J Orthop Sci. 2023 Sep;28(5):1004-1010. doi: 10.1016/j.jos.2022.07.001. Epub 2022 Aug 6.

  PMID: 35945122 DERIVED

MeSH Terms

Conditions

Parkinson Disease; Shoulder Pain

Interventions

High-Energy Shock Waves

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Arthralgia; Joint Diseases; Musculoskeletal Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 3, 2016
• First Posted: March 8, 2016
• Study Start: January 1, 2016
• Primary Completion: December 1, 2017
• Study Completion: January 1, 2018
• Last Updated: December 23, 2020

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)