Impact of Genetic Polymorphism on Propofol Requirement and Recovery for Total Intravenous Anesthesia for Clipping of Unruptured Cerebral Aneurysm in Korean Population

NCT02700126 | Completed DMC

• 1 other identifier: 4-2015-1195
• Study Type: observational
• Target: 118
• Locations: 1 country
• Sites: 1

Brief Summary

In neurosurgical anesthesia, propofol based total intravenous anesthesia (TIVA) is frequently used due to brain relaxation and less effect on electrophysiologic monitoring. Response to propofol can vary between individuals and be associated with clinical factors including age and weight, and genetic polymorphism. Because the importance of rapid recovery in neurosurgery with long operation time is emphasized recently, the choice and dose adjustment of anesthetics should be determined according to clinical and genetic factors. Recently, researches about genetic variations have been performed with single nucleotide polymorphism (SNP). The aim of this study is to determine SNPs associated with propofol recovery and response in Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm.

Conditions

Unruptured Cerebral Aneurysm

Keywords

propofol; total intravenous anesthesia; cerebral aneurysm; single nucleotide polymorphism

Outcome Measures

Primary Outcomes (1)

• Time of eye opening after stopping propofol infusion

  within about one hour from end of surgery

Study Arms (1)

undergoing propofol based TIVA for clip

This study is an observational study performed in adult patients undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm. We will collect data regarding recovery after stopping propofol infusion (time for eye opening and extubation), propofol requirement during anesthesia maintenance, and propofol effect site concentration to achieve bispectral index 40 during anesthesia induction, without doing any interventions. Data collection will be established with just observing and recording values displayed in screens of monitoring devices, and reviewing patient charts.

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Korean adult population undergoing propofol based total intravenous anesthesia for clipping of unruptured cerebral aneurysm.

You may qualify if:

• \. Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm

You may not qualify if:

• patients not able to read, or understand the consent form
• ethnicity, other than Korean population
• patients refusal
• patients not to perform total intravenous anesthesia

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, Seoul, 03722, South Korea

Location

Related Publications (1)

• Iohom G, Ni Chonghaile M, O'Brien JK, Cunningham AJ, Fitzgerald DF, Shields DC. An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia. Eur J Anaesthesiol. 2007 Nov;24(11):912-9. doi: 10.1017/S0265021507000476. Epub 2007 Jun 7.

  PMID: 17555608 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Blood obtained from enrolled patients before surgery

MeSH Terms

Conditions

Intracranial Aneurysm

Condition Hierarchy (Ancestors)

Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Aneurysm; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 26, 2016
• First Posted: March 7, 2016
• Study Start: March 7, 2016
• Primary Completion: February 22, 2017
• Study Completion: February 22, 2017
• Last Updated: March 10, 2017

Record last verified: 2017-03

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)