Physician Judgment and Machine Predictions

NCT02694159 | Completed

• 1 other identifier: 823464
• Study Type: observational
• Target: 50,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study goal is to improve the value of care and reduce health disparities by developing a targeted set of sophisticated and powerful algorithms to improve upon human clinical judgments. The plan is to use the test case of detecting sepsis in patients in the emergency department (ED) as the first step in improving the value of care and reducing health disparities by developing a targeted set of sophisticated and powerful algorithms to improve upon human clinical judgments. This work will be performed using data from the University of Pennsylvania Health System where a preliminary Early Warning and Response System for Sepsis monitors clinical parameters. The premise underlying all this work is that by improving decision-making, it will both reduce low-value care and health disparities.

Conditions

Sepsis

Outcome Measures

Primary Outcomes (1)

• Patients developing sepsis

  The primary outcome variable is whether patients developed sepsis.

  Two years

Secondary Outcomes (2)

• Under- and over-diagnosis of sepsis

  Two years

• Treatment decisions among patients in the emergency department

  Two years

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Clinical data on tens of thousands of patients presented to ED and transferred to ICUs or general hospital units within the University of Pennsylvania Health System from 2008 to 2014.

You may qualify if:

• Patients presented to EDs and transferred to ICUs or general hospital units within the University of Pennsylvania Health System

You may not qualify if:

• Children and adolescents

Sponsors & Collaborators

• University of Pennsylvania: lead
• Harvard University: collaborator

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Amol Navathe, MD, PhD

  University of Pennsylvania

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 18, 2016
• First Posted: February 29, 2016
• Study Start: February 1, 2016
• Primary Completion: December 30, 2021
• Study Completion: December 30, 2021
• Last Updated: July 22, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share