Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study

NCT02682706 | Completed

• 1 other identifier: EKNZ BASEC 2015-00199
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 2

Brief Summary

Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance. Currently, the imaging method of choice to assess BAT morphology and function is 18F-FDG-PET/CT which is expensive and exposes patients or healthy volunteers to ionizing radiation, thus impeding larger prospective studies. Magnetic resonance imaging (MRI) could constitute a suitable alternative and preliminary small-scale studies are promising. The overall aim of this research proposal is to develop reliable magnetic resonance imaging techniques to facilitate the study of brown adipose tissue in human adults, specifically in the context of endocrine disease. Specifically, investigators want to

1. 1.Develop a reliable MR imaging protocol for human BAT and compare BAT volume to cold induced nonshivering thermogenesis as a measure of BAT activity.
2. 2.Assess the intra-individual variance of BAT volume measured by MRI.
3. 3.Evaluate direct measurement of BAT temperature by functional MRI.

Conditions

Healthy

Keywords

brown adipose tissue; magnetic resonance imaging; energy expenditure; non-shivering thermogenesis

Outcome Measures

Primary Outcomes (1)

• Correlation of scBAT volume and cold induced thermogenesis as determined by indirect calorimetry

  measurement of scBAT volume and measurement of cold induced thermogenesis as determined by indirect calorimetry, both values measured in a timeframe of two weeks

  both measurements within 2 weeks

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

healthy volunteers

You may qualify if:

• Healthy volunteers
• Age 18-40 years
• Body mass index (BMI): 17.5-27 kg/m²

You may not qualify if:

• known concomitant disease influencing thyroid hormone metabolism
• severe diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer
• known hypersensitivity to cold, e.g. primary or secondary Raynaud's syndrome
• abuse of alcohol or illicit drugs
• Women who are pregnant or breast feeding
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
• Previous enrolment into the current study
• implanted device not compatible with MRI, e.g. pace maker

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Study Sites (2)

University Hospital Basel, Department of Endocrinology

Basel, Canton of Basel-City, 4031, Switzerland

Location

University Hospital of Basel, Department of Radiology

Basel, Canton of Basel-City, 4031, Switzerland

Location

Related Publications (1)

• Senn JR, Maushart CI, Gashi G, Michel R, Lalive d'Epinay M, Vogt R, Becker AS, Muller J, Balaz M, Wolfrum C, Burger IA, Betz MJ. Outdoor Temperature Influences Cold Induced Thermogenesis in Humans. Front Physiol. 2018 Aug 23;9:1184. doi: 10.3389/fphys.2018.01184. eCollection 2018.

  PMID: 30190681 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

plasma

Study Officials

• Matthias J Betz, MD

  University Hospital, Basel, Switzerland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2016
• First Posted: February 15, 2016
• Study Start: February 1, 2016
• Primary Completion: March 1, 2018
• Study Completion: March 1, 2018
• Last Updated: April 6, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will not share

Locations

CH (2)