TR-987 vs. Placebo Following Fractionated CO2 Laser Resurfacing of the Chest

NCT02681224 | Completed

• 1 other identifier: TR987-2013-01
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

A single site, double-blind, randomized, placebo-controlled, clinical study comparing the difference between a novel healing gel and a placebo gel on post laser-resurfacing chests.

Conditions

Exposure Laser

Outcome Measures

Primary Outcomes (1)

• Rate of Healing

  Day 28

Study Arms (4)

Active Product with Occlusion

ACTIVE COMPARATOR

TR987 Gel with Silon Bandage

Other: TR987 Gel with Silon Bandage

Active Product without Occlusion

ACTIVE COMPARATOR

TR987 without Silon Bandage

Other: TR987 without Silon Bandage

Placebo Gel with Occlusion

PLACEBO COMPARATOR

Placebo Gel with Silon Bandage

Other: Placebo Gel with Silon Bandage

Placebo Gel without Occlusion

PLACEBO COMPARATOR

Placebo Gel without Silon Bandage

Other: Placebo Gel without Silon Bandage

Interventions

TR987 Gel with Silon Bandage OTHER

Novel healing gel with occlusive dressing

Active Product with Occlusion

TR987 without Silon Bandage OTHER

Novel healing gel without occlusive dressing

Active Product without Occlusion

Placebo Gel with Silon Bandage OTHER

Placebo gel with occlusive dressing

Placebo Gel with Occlusion

Placebo Gel without Silon Bandage OTHER

Placebo Gel without occlusive dressing

Placebo Gel without Occlusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Females or males in good general health greater than 18 years of age.
• Must be willing to give and sign a HIPPA form, informed consent form, and a photographic release form
• Subject is planning to undergo fractionated CO2 laser resurfacing to the chest
• A potential subject's must exhibit:
• Skin phototype of Fitzpatrick Type I-IV
• For FEMALE SUBJECT OF CHILDBEARING POTENTIAL, must have had a regular menstrual cycle prior to study entry (a female is considered of childbearing potential unless she is postmenopausal, without a uterus and/or both ovaries, or has had a bilateral tubal ligation) and is willing to use an acceptable form of birth control during the entire course of the study \[i.e., acceptable methods of birth control are oral contraceptives, contraceptive patches/rings/implants Norplant®, Depo-Provera®, double-barrier methods (e.g. condoms and spermicide), abstinence and vasectomies of partner with a documented second acceptable method of birth control should the subject become sexually active\]. All systemic birth control measures must be in consistent use at least 30 days prior to study participation. Postmenopausal is defined as having the last menstrual cycle in at least 12 months
• Negative urine pregnancy test results at the time of study entry (if applicable)
• Must be willing to comply with study dosing and complete the entire course of the study.

You may not qualify if:

• A subject with any UNCONTROLLED systemic disease at the discretion of the Investigator. A potential subject in whom therapy for a systemic disease is not yet stabilized will not be considered for entry into the study
• A subject with a significant history or current evidence of a medical, psychological or other disorder that, in the investigator's opinion, would preclude enrollment into the study.
• A subject with recently excessive exposure to sunlight or artificial UV light (e.g.: use of tanning beds/booths and/or sunbathing) or expectations of tanning during the time of the study or has used self-tanner within 7 days of study entry.
• A subject with history of or the presence of any skin condition/disease that might interfere with the diagnosis or evaluation of study parameters (i.e., atopic dermatitis, eczema, psoriasis, seborrheic dermatitis) at the discretion of the investigator.
• A subject with an active bacterial, fungal, or viral infection in the treatment area.
• A subject with known allergies or sensitivities to benzocaine, lidocaine, tetracaine, PABA (para-aminobenzoic acid), or other local anesthetics of the amide or ester family sedation medication.
• A subject with known allergy or sensitivity to propylene glycol or any other ingredient of topical TR-987 or placebo.
• A subject receiving any topical products containing alpha-hydroxy acids, salicylic acid, and vitamins C or E (includes derivatives thereof) on the chest within 14 days prior to or during the study period, other than the study products
• A subject receiving any investigational drug and/or has had a microdermabrasion (light or medium skin peel) treatment on their chest within 30 days prior to or during the study period
• A subject using any topical tretinoin product or derivative on their chest within 12 weeks prior to or during the study period
• A subject receiving a chemical peel, any systemic steroids, a non-ablative laser, light or radio frequency treatment and/or has had a Dermabrasion (deep skin peel) or ablative laser treatments on their chest must have discontinued the drug/treatment and/or have completed the treatment or the procedure at least 3 months prior to entering the study.
• A subject with a history of keloids or hypertrophic scars
• A subject that has previously been treated with a systemic retinoid within the past year (e.g., Accutane®, Roche Dermatologics)
• A female subject who is pregnant, nursing an infant or planning a pregnancy during the study \[throughout the course of the study, women of child-bearing potential must use reliable forms of contraception (i.e., oral contraceptive, contraceptive patches/rings/implants Norplant®, Depo-Provera®, double-barrier methods (e.g. condoms and spermicide), abstinence, or vasectomies of partner with a documented second acceptable method of birth control should the subject become sexually active\].
• Current participation or participation within 30 days prior to the start of this study in a drug or other investigational research study.

Sponsors & Collaborators

• Goldman, Butterwick, Fitzpatrick and Groff: lead

Study Sites (1)

Cosmetic Laser Dermatology

San Diego, California, 92121, United States

Location

Study Officials

• Mitchel P Goldman, MD

  Cosmetic Laser Dermatology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 8, 2016
• First Posted: February 12, 2016
• Study Start: September 1, 2015
• Primary Completion: September 1, 2016
• Study Completion: January 1, 2017
• Last Updated: March 1, 2017

Record last verified: 2017-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)