Exercise Dosing Trial for Individuals With Parkinson's Disease

NCT02676804 | Completed

• 1 other identifier: 18664
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective, pre-post intervention study to evaluate the effect of a high-intensity, aerobic exercise program on outcomes of cognition, mood, gait, balance, cardiorespiratory fitness, neuromuscular performance, fatigue, sleep, and quality of life for patients diagnosed with idiopathic Parkinson disease. The primary outcomes will be a composite measure of cognitive function and the Timed Up and Go (TUG).

Conditions

Parkinsons Disease

Keywords

Exercise

Outcome Measures

Primary Outcomes (1)

• Global Composite Cognitive Score

  16 weeks

Study Arms (1)

High-intensity aerobic exercise

EXPERIMENTAL

Subjects will participate in a 16 week high-intensity aerobic exercise program.

Other: High-intensity, aerobic exercise.

Interventions

High-intensity, aerobic exercise. OTHER

Aerobic exercise will blend unsupervised moderate and supervised high intensity exercise. It will consist of walking/jogging modalities, dependent on the subject's level of bradykinesia, paced by the subject's level of perceived exertion. The exercise protocol will be designed to target an total of at least 150 minutes of cardio exercise per week. Exercise training will be performed 5 times per week for 6 weeks, consisting of 3 supervised high intensity sessions and 2 at home moderate intensity sessions. High intensity sessions will be performed on a treadmill at an intensity rating of \~ 15 and 17 on a rating of perceived exertion (RPE) scale of 6 to 20. The moderate intensity exercise will target an RPE of \~10 - 12 and participants will be asked to complete this on their own.

High-intensity aerobic exercise

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects with idiopathic Parkinson Disease as determined by United Kingdom Brain Bank Criteria. This includes the presence of bradykinesia with one or both of the following: rest tremor and/or rigidity
• Asymmetric onset of PD and progressive motor symptoms.
• Hoehn and Yahr stage 2 or 3.
• Stable dopaminergic medication regimen for 4 weeks prior to baseline visit with no anticipated changes for the duration of the study.
• Stable doses of medications known to affect sleep and medications for Parkinson's Disease for at least 4 weeks prior to study entry without anticipation of medication change for the duration of the study.
• Ability to complete exercise intervention and assessment visits during at least 16 weeks of intervention (3x/week for 16 weeks).
• Must pass a physical examination to assess exercise readiness.
• Women of childbearing potential may enroll but must use a reliable measure of contraception and have a negative serum pregnancy test at the screening visit.
• Montreal Cognitive Assessment score ≥ 18 and ≤30.
• Ability to pass a Physical Activity Readiness Questionnaire to assess exercise readiness.

You may not qualify if:

• Atypical features indicative of a Parkinson's Plus disorder (Progressive Supranuclear Palsy, Multiple Systems Atrophy, Corticobasal Degeneration) including cerebellar signs, supranuclear gaze palsy, apraxia, prominent autonomic failure, or other cortical signs.
• Neuroleptic treatment at time of onset of Parkinsonism
• Active treatment with a neuroleptic at time of study entry. Exceptions to this are quetiapine and clozapine.
• History of multiple strokes with stepwise progression of Parkinsonism
• History of multiple head injuries
• Inability to walk without assistance, including a cane, wheelchair, or walker
• Regular participation in an exercise program within the past 6 months.
• Deep Brain Stimulation or other neurosurgical procedure for PD.
• Untreated sleep apnea
• Known narcolepsy
• Participation in drug studies or the use of investigational drugs within 30 days prior to screening
• Acute illness or active, confounding medical, neurological, or musculoskeletal conditions that, at the discretion of the PI, would prevent the subject's ability to participate in the study
• Known contraindication to testing
• Active alcoholism or other drug addiction
• Pregnancy

Sponsors & Collaborators

• University of Virginia: lead

Study Sites (1)

University of Virginia Health System

Charlottesville, Virginia, 22908, United States

Location

MeSH Terms

Conditions

Parkinson Disease; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Harrison B Madaline, MD

  University of Virginia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 1, 2016
• First Posted: February 8, 2016
• Study Start: March 1, 2016
• Primary Completion: August 1, 2019
• Study Completion: August 1, 2019
• Last Updated: November 4, 2022

Record last verified: 2022-11

Locations

US (1)